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c-Jun/AP-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AP-1 (5) JNK (1) Apoptosis (5) Bcl-2 Family (1) c-Myc (1) Caspase (1) COX (3) DNA/RNA Synthesis (1) ERK (2) Interleukin Related (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Mitochondrial Metabolism (1) MMP (4) NF-κB (1) p38 MAPK (1) PARP (1) PPAR (2) Reactive Oxygen Species (ROS) (1) Reference Standards (1) TGF-beta/Smad (1) TNF Receptor (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Inflammation/Immunology (6) Metabolic Disease (2) Neurological Disease (1)

Inhibitors & Agonists

Natural
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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: JNK AP-1 AAK1 MetAP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12270

T-5224 95+ Cited Publications	AP-1 MMP	Neurological Disease Inflammation/Immunology Cancer
T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-W010983

SC-236 2 Publications Verification	COX PPAR Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
SC-236 is an orally active COX-2 specific inhibitor (IC₅₀ = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model .

HY-N1326

Santamarine Santamarin; Balchanin	JNK p38 MAPK MMP NF-κB COX TNF Receptor Interleukin Related Reactive Oxygen Species (ROS) Apoptosis Mitochondrial Metabolism DNA/RNA Synthesis Keap1-Nrf2 Bcl-2 Family Caspase PARP TGF-beta/Smad	Metabolic Disease Inflammation/Immunology Cancer
Santamarine (Santamarin; Balchanin) is a sesquiterpene lactone found in Artemisia scoparia. Santamarine shows anti-inflammatory, antioxidant, anticancer and anti-photoaging activities. Santamarine suppresses UVA-induced phosphorylation of JNK and p38 MAPK, nuclear translocation of phosphorylated c-Fos and c-Jun, and AP-1-mediated MMP-1 transcription and secretion. Santamarine suppresses NF-κB signaling, iNOS, COX-2, TNF-α, and IL-1β production. Santamarine inhibits thioredoxin reductase activity, induces ROS production, mitochondrial apoptosis, G2/M cell cycle arrest, and DNA damage, and reduces cancer cell growth. Santamarine can be used for the photoaging, inflammatory diseases and cancer .

HY-113443

12(S)-HPETE	AP-1	Metabolic Disease
12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension .

HY-168895

c-Fos-IN-1	AP-1 ERK Apoptosis	Cancer
c-Fos-IN-1 (Compound P16) is a *c-Jun* inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of *AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC₅₀: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis*. c-Fos-IN-1 inhibits gastric cancer tumor growth .

HY-12270R

T-5224 (Standard)	AP-1 MMP	Others
T-5224 (Standard) is the analytical standard of T-5224. This product is intended for research and analytical applications. T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-W010983R

SC-236 (Standard)	Reference Standards COX PPAR Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
SC-236 is an orally active COX-2 specific inhibitor (IC50 = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model .

HY-12270S

T-5224-d8	Isotope-Labeled Compounds AP-1 MMP	Inflammation/Immunology
T-5224-d₈ is the deuterium labeled T-5224 (HY-12270). T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

HY-180419

SF-3-030	ERK Apoptosis c-Myc	Inflammation/Immunology Cancer
SF-3-030 is a potent, selective and non-ATP competitive ERK1/2 inhibitor. SF-3-030 selectively induces apoptosis in melanoma cells containing mutated BRaf and constitutively active ERK1/2 signalling. SF-3-030 mitigates multiple features of asthma in a murine model of asthma. SF-3-030 can be used for the research of asthma and melanomasup .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1326

Santamarine Santamarin; Balchanin	Classification of Application Fields Terpenoids Sesquiterpenes Magnoliaceae Plants Inflammation/Immunology Disease Research Fields Magnolia grandiflora L. Source Classification	JNK p38 MAPK MMP NF-κB COX TNF Receptor Interleukin Related Reactive Oxygen Species (ROS) Apoptosis Mitochondrial Metabolism DNA/RNA Synthesis Keap1-Nrf2 Bcl-2 Family Caspase PARP TGF-beta/Smad
Santamarine (Santamarin; Balchanin) is a sesquiterpene lactone found in Artemisia scoparia. Santamarine shows anti-inflammatory, antioxidant, anticancer and anti-photoaging activities. Santamarine suppresses UVA-induced phosphorylation of JNK and p38 MAPK, nuclear translocation of phosphorylated c-Fos and c-Jun, and AP-1-mediated MMP-1 transcription and secretion. Santamarine suppresses NF-κB signaling, iNOS, COX-2, TNF-α, and IL-1β production. Santamarine inhibits thioredoxin reductase activity, induces ROS production, mitochondrial apoptosis, G2/M cell cycle arrest, and DNA damage, and reduces cancer cell growth. Santamarine can be used for the photoaging, inflammatory diseases and cancer .

HY-113443

12(S)-HPETE	Microorganisms Source Classification	AP-1
12(S)-HPETE is a 12-hydroxyeicosatetraenoic acid. 12(S)-HPETE has the function of regulating vascular tone. 12(S)-HPETE induces the expression of c-Fos and c-Jun protein and increases activating protein 1 (AP-1) activity in vascular smooth muscle cells.12(S)-HPETE may play a physiological role in vasomotor regulation through endothelium itself and crosstalk between blood cells and endothelium. 12(S)-HPETE can be used in the study of cerebrovascular tension .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702589

	JUN Protein, Human (His, Myc) Activator protein 1; AP1; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun; V-Jun avian sarcoma virus 17 oncogene homolog; p39	Human	E. coli
	JUN Protein, Human (His, Myc) is the recombinant human-derived JUN, expressed by E. coli , with N-10*His, C-Myc labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-12270S

T-5224-d8
T-5224-d₈ is the deuterium labeled T-5224 (HY-12270). T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription .

Host:	Mouse (2) Rabbit (7)
Reactivity:	Human (9) Rat (7) Mouse (9) Monkey (2)
Application:	IHC-P (6) ICC/IF (3) IP (2) WB (9) FC (3) ELISA (2)
Isotype:	IgG (7) IgG1 (2)
Conjugation:	Non-conjugated (9)
Clonality:	Polyclonal (2) Monoclonal (4) Recombinant (3)
Modification:	Phosphorylated (4) Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83960

	c-Jun Antibody (YA3657) AP1; AP-1; c-Jun; Jun	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey
	c-Jun Antibody (YA3657) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to c-Jun.

HY-P83960A

	c-Jun Antibody (YA3657)(PBS only) AP1; AP-1; c-Jun; Jun	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey
	c-Jun Antibody (YA3657) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to c-Jun.

HY-P80800

	Phospho-c-Jun (Ser243) Antibody Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-Jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser243) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-c-Jun (Ser243).

HY-P80802

	Phospho-c-Jun (Ser73) Antibody Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-Jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser73) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-c-Jun (Ser73).

HY-P80801

	Phospho-c-Jun (Ser63) Antibody (YA215) Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-Jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser63) Antibody (YA215) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-c-Jun (Ser63).

HY-P80801A

	Phospho-c-Jun (Ser63) Antibody (YA215)(PBS only) Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-Jun avian sarcoma virus 17 oncogene homolog; p39	WB, IHC-P	Human, Mouse, Rat
	Phospho-c-Jun (Ser63) Antibody (YA215) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-c-Jun (Ser63).

HY-P82861

	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) Jun; Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-Jun avian sarcoma virus 17 oncogene homolog; p39; JunD; Transcription factor Jun-D	WB, IP	Human, Mouse, Rat
	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Jun/JunD (Ser73/Ser100).

HY-P82861A

	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606)(PBS only) Jun; Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-Jun avian sarcoma virus 17 oncogene homolog; p39; JunD; Transcription factor Jun-D	WB, IP	Human, Mouse, Rat
	Phospho-Jun/JunD (Ser73/Ser100) Antibody (YA2606) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Jun/JunD (Ser73/Ser100).

HY-P810405

	Phospho-c-Jun (S73)+JunD (S100) Antibody (YA9720) Activator protein 1, AP 1, AP-1, AP1, cJun, Enhancer Binding Protein AP1, Jun Activation Domain Binding Protein, Jun, Jun oncogene, Jun protein	WB, ICC/IF, FC	Human, Mouse, Rat
	Phospho-c-Jun (S73)+JunD (S100) Antibody (YA9720) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Phospho-c-Jun(S73)+JunD(S100) .

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c-Jun/AP-1

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
Products