4290-13-5
Chemical Structure
Santamarine
Synonym(s): Santamarin; Balchanin
- CAS No.: 4290-13-5
- Formula:C15H20O3
- Molecular Weight:248.32
IUPAC Name: (3aS,5aR,6R,9aS,9bS)-6-hydroxy-5a,9-dimethyl-3-methylene-3a,4,5,5a,6,7,9a,9b-octahydronaphtho[1,2-b]furan-2(3H)-one
InChIKey: PLSSEPIRACGCBO-PFFFPCNUSA-N
SMILES: O=C(O[C@@]1([H])[C@@]2([H])CC[C@@]3(C)[C@H](O)CC=C(C)[C@@]31[H])C2=C
Biological Activity: Santamarine (Santamarin; Balchanin) is a sesquiterpene lactone found in Artemisia scoparia. Santamarine shows anti-inflammatory, antioxidant, anticancer and anti-photoaging activities. Santamarine suppresses UVA-induced phosphorylation of JNK and p38 MAPK, nuclear translocation of phosphorylated c-Fos and c-Jun, and AP-1-mediated MMP-1 transcription and secretion. Santamarine suppresses NF-κB signaling, iNOS, COX-2, TNF-α, and IL-1β production. Santamarine inhibits thioredoxin reductase activity, induces ROS production, mitochondrial apoptosis, G2/M cell cycle arrest, and DNA damage, and reduces cancer cell growth. Santamarine can be used for the photoaging, inflammatory diseases and cancer[1][2][3][4].
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Santamarine | 98.85% | Santamarine (Santamarin; Balchanin) is a sesquiterpene lactone found in Artemisia scoparia. Santamarine shows anti-inflammatory, antioxidant, anticancer and anti-photoaging activities. Santamarine suppresses UVA-induced phosphorylation of JNK and p38 MAPK, nuclear translocation of phosphorylated c-Fos and c-Jun, and AP-1-mediated MMP-1 transcription and secretion. Santamarine suppresses NF-κB signaling, iNOS, COX-2, TNF-α, and IL-1β production. Santamarine inhibits thioredoxin reductase activity, induces ROS production, mitochondrial apoptosis, G2/M cell cycle arrest, and DNA damage, and reduces cancer cell growth. Santamarine can be used for the photoaging, inflammatory diseases and cancer. | ||||||||||||||||||||
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- [1]. Oh JH, et al. Santamarine Shows Anti-Photoaging Properties via Inhibition of MAPK/AP-1 and Stimulation of TGF-β/Smad Signaling in UVA-Irradiated HDFs. Molecules. 2021;26(12):3585. Published 2021 Jun 11. [Content Brief]
- [2]. Choi HG, et al. Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells. Int Immunopharmacol. 2012;13(3):271-279. [Content Brief]
- [3]. Wu X, et al. Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress. Biomed Res Int. 2017;2017:4734127. [Content Brief]
- [4]. Lu H I, et al. Michelia compressa-derived santamarine inhibits oral cancer cell proliferation via oxidative stress-mediated apoptosis and DNA damage[J]. Pharmaceuticals, 2024, 17(2): 230. [Content Brief]
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