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Results for "

cholesterol-lowering

" in MedChemExpress (MCE) Product Catalog:

51

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2

Biochemical Assay Reagents

6

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14

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4

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0527
    Pentagalloylglucose
    Maximum Cited Publications
    15 Publications Verification

    Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose

    		 JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species (ROS) E1/E2/E3 Enzyme Neurological Disease Inflammation/Immunology Cancer
    Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloylglucose inhibits UBE2T-mediated p53 ubiquitination, upregulates p53, downregulates RRM1/RRM2 in pancreatic cancer organoids. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .
    Pentagalloylglucose
  • HY-N1459
    Campesterol
    4 Publications Verification

    		 Endogenous Metabolite Cancer
    Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.
    Campesterol
  • HY-134124
    Glutathione ethyl ester

    		Reactive Oxygen Species (ROS) Metabolic Disease
    Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .
    Glutathione ethyl ester
  • HY-N6811
    1-Octacosanol

    		Insecticide Infection Cardiovascular Disease
    1-Octacosanol is a straight-chain aliphatic 28-carbon fatty alcohol and a major component of the cholesterol-lowering agent Policosanol. 1-Octacosanol exhibits various activities such as anti-fatigue, anti-angiogenic, cholesterol-lowering, and insecticidal effects .
    1-Octacosanol
  • HY-W008226
    Phloracetophenone

    2,4,6-trihydroxyacetophenone; 1-(2,4,6-Trihydroxyphenyl)ethanone

    		 Cytochrome P450 Bacterial Antibiotic Infection Metabolic Disease
    Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity . Phloracetophenone stimulats bile secretion mediated through Mrp2 .
    Phloracetophenone
  • HY-128749
    D-Glucaric acid potassium

    Potassium D-glucarate

    		 Endogenous Metabolite Apoptosis Metabolic Disease Inflammation/Immunology Cancer
    D-Glucaric acid potassium (Potassium D-glucarate) is an orally active end product of the D-glucuronic acid pathway in mammals. D-Glucaric acid potassium is present in a variety of fruits and vegetables. D-Glucaric acid potassium has cholesterol-lowering and anti-tumor activities. D-Glucaric acid potassium can inhibit tumor cell proliferation and inflammation, and induce apoptosis .
    D-Glucaric acid potassium
  • HY-N8425
    Octacosanoic acid

    Montanic acid

    		 Endogenous Metabolite Metabolic Disease
    Octacosanoic acid is a very long-chain saturated fatty acid. It is the major component of D-003, a mixture of very long-chain aliphatic acids purified from sugar cane wax that has antiplatelet and cholesterol-lowering activities in animal models .
    Octacosanoic acid
  • HY-N9811
    Hydroxytyrosol 4-O-glucoside

    		Drug Derivative Infection Metabolic Disease
    Hydroxytyrosol 4-O-glucoside is a phenolic compound found in olive pulp, vegetation water, and pomace of olive oil processing. Hydroxytyrosol 4-O-glucoside can be used in research on antibacterial, hypoglycemic, lipid-lowering, and cholesterol-lowering effects .
    Hydroxytyrosol 4-O-glucoside
  • HY-N0131R
    Stigmasterol (Standard)
    10+ Cited Publications

    Stigmasterin (Standard)

    		 Reference Standards MMP Endogenous Metabolite Inflammation/Immunology
    Stigmasterol (Standard) is the analytical standard of Stigmasterol (HY-N0131). This product is intended for research and analytical applications. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.
    Stigmasterol (Standard)
  • HY-W414588
    Colestolone

    		HMG-CoA Reductase (HMGCR) CETP Metabolic Disease
    Colestolone is a 15-ketosterol compound and an orally active inhibitor of HMG-CoA reductase. Colestolone can inhibit the activity of cholesteryl ester transfer protein (CETP) in vitro (IC50 = 660 μM). Colestolone is a cholesterol-lowering agent, and can be used in the research of endocrine and metabolic diseases such as hyperlipidemia .
    Colestolone
  • HY-NP026
    Spirulina C-phycocyanin

    C-phycocyaninfromporphyratenera

    		 SOD Integrin Inflammation/Immunology
    Spirulina C-phycocyanin, a component of the light-harvesting phycobilisome complex in photosystem II, is a highly dominant chromoprotein in Spirulina. Spirulina C-phycocyanin can be detected by Raman spectral measurement. Spirulina C-phycocyanin has antioxidant, anti-inflammatory, antiplatelet, liver-protective and cholesterol-lowering effects .
    Spirulina C-phycocyanin
  • HY-128749A
    D-Glucaric acid tetrahydrate

    Calcium D-glucarate tetrahydrate

    		 Endogenous Metabolite Apoptosis Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    D-Glucaric acid tetrahydrate (Calcium D-glucarate tetrahydrate) is an orally active end product of the mammalian D-glucuronidation pathway. D-Glucaric acid tetrahydrate is found in a variety of fruits and vegetables. D-Glucaric acid tetrahydrate induces cell Apoptosis. D-Glucaric acid tetrahydrate reduces the expression of hippocampal myelin-related genes (Mbp, Plp1). D-Glucaric acid tetrahydrate has cholesterol-lowering and anti-tumor activities. D-Glucaric acid tetrahydrate can be used in the research of neurological diseases .
    D-Glucaric acid tetrahydrate
  • HY-19513
    MB-07344

    		Thyroid Hormone Receptor Metabolic Disease Endocrinology
    MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys .
    MB-07344
  • HY-B0589H
    Atorvastatin strontium

    		HMG-CoA Reductase (HMGCR) Autophagy Cardiovascular Disease
    Strontium atorvastatin is a cholesterol-lowering drug with activity in ameliorating cardiovascular disease-related events. Strontium atorvastatin exerts its biological activity by inhibiting HMG-CoA reductase in liver tissue. Strontium atorvastatin is also used to suppress dyslipidemia .
    Atorvastatin strontium
  • HY-124064
    TMP-153

    		Acyltransferase Metabolic Disease
    TMP-153 is an orally active inhibitor of ACAT with an IC50 value of approximately 5-10 nM against hepatic and intestinal ACAT in varicose animals. TMP-153 exhibits cholesterol-lowering effects and can be utilized in the research of atherosclerosis .
    TMP-153
  • HY-B2097
    Incadronate disodium

    YM 175; Bisphonal

    		 Farnesyl Transferase Metabolic Disease
    Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (Ki=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC50=64 μM). Incadronate disodium has the potential for malignant tumors research .
    Incadronate disodium
  • HY-W353225
    Pyricarbate

    Pyridinol carbamate

    		 Others Cardiovascular Disease
    Pyricarbate (Pyridinol carbamate) is an orally active 2,6-pyridine dimethanol biscarbamate with cholesterol-lowering and antiatherosclerotic effects .
    Pyricarbate
  • HY-B0893
    3-Pyridinemethanol

    Nicotinyl alcohol; Pyridine-3-carbinol

    		 CETP Metabolic Disease
    3-Pyridinemethanol (Nicotinyl alcohol), a pyridine derivative, is a cholesterol-lowering agent. 3-Pyridinemethanol can be selectively oxidized to vitamin B3 .
    3-Pyridinemethanol
  • HY-178015
    THR-β agonist 11

    		Thyroid Hormone Receptor Metabolic Disease Inflammation/Immunology
    THR-β agonist 11 is an orally active and selective thyroid hormone receptor (THR-β) agonist. THR-β agonist 11 shows potent cholesterol-lowering activity in cholesterol-fed rats. THR-β agonist 11 significantly reduces serum total TG, LDL-cholesterol, liver total TC and TG levels, and alleviates hepatic steatosis, inflammation and fibrosis in HFD-CCl4-induced Metabolic dysfunction-associated steatohepatitis (MASH) model mice. THR-β agonist 11 can be used for the study of metabolic dysfunction-associated steatohepatitis (MASH) and other fibrotic diseases .
    THR-β agonist 11
  • HY-100288
    RP 73163 Racemate

    		Acyltransferase Metabolic Disease
    RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent ACAT inhibitor, with cholesterol lowering activity.
    RP 73163 Racemate
  • HY-19513A
    MB-07344 sodium

    		Thyroid Hormone Receptor Metabolic Disease Endocrinology
    MB-07344 sodium is a potent thyroid hormone receptor (TR)-β agonist with a Ki of 2.17 nM. MB-07344 sodium has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys .
    MB-07344 sodium
  • HY-116241
    L-157012

    		HMG-CoA Reductase (HMGCR) Metabolic Disease
    L-157012 is a HMG-CoA reductase (HMGCR) inhibitor. L-157012 is also a cholesterol-lowering agent .
    L-157012
  • HY-116595
    J-104118

    		Farnesyl Transferase Metabolic Disease
    J-104118 is a potent and orally active squalene synthase (SQS) inhibitor with an IC50 of 0.52 nM. J-104118 inhibits cholesterol synthesis in mice. J-104118 can be used for cholesterol-lowering research .
    J-104118
  • HY-161941
    MeIm

    		LDLR PCSK9 Cardiovascular Disease
    MeIm (compound 7) is a high-affinity PCSK9 targeting peptide mimetic with cholesterol-lowering activity. MeIm increases cellular uptake of LDL (EC50=6.04 μM) by inhibiting the binding of PCSK9 to LDLR (IC50=11.2 μM). MeIm can be used in the study of cardiovascular diseases .
    MeIm
  • HY-W015467
    Pyridine-3-sulfonic acid

    Pyridine-3-sulphonic acid

    		 Drug Derivative Metabolic Disease
    Pyridine-3-sulfonic acid (Pyridine-3-sulphonic acid) is an orally active structural analog of Nicotine acid (HY-B0143). Pyridine-3-sulfonic acid significantly reduces hepatic cholesterol synthesis in rats but lacks cholesterol-lowering activity. Pyridine-3-sulfonic acid does not interfere with the metabolism of Nicotine acid .
    Pyridine-3-sulfonic acid
  • HY-N1459R
    Campesterol (Standard)

    (24R)-5-Ergosten-3β-ol (Standard)

    		 Reference Standards Endogenous Metabolite Cancer
    Campesterol (Standard) is the analytical standard of Campesterol. This product is intended for research and analytical applications. Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.
    Campesterol (Standard)
  • HY-19264
    264W94

    		Apical Sodium-Dependent Bile Acid Transporter Metabolic Disease
    264W94 is a potent ileal bile acid transporter (IBAT) inhibitor and a new cholesterol lowering agent. 264W94 has CYP7A1 induction, and antilipemic action .
    264W94
  • HY-P2424
    Cholecystokinin-J

    CCK-J

    		 Calcium Channel Others
    Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca 2+ release .
    Cholecystokinin-J
  • HY-N0527R
    Pentagalloylglucose (Standard)

    Penta-O-galloyl-β-D-glucose (Standard); 1,2,3,4,6-Pentagalloyl glucose (Standard)

    		 Reference Standards JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species (ROS) Neurological Disease Inflammation/Immunology Cancer
    Pentagalloylglucose (Standard) is the analytical standard of Pentagalloylglucose. This product is intended for research and analytical applications. Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloylglucose inhibits UBE2T-mediated p53 ubiquitination, upregulates p53, downregulates RRM1/RRM2 in pancreatic cancer organoids. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .
    Pentagalloylglucose (Standard)
  • HY-B0723S
    Ospemifene-d4

    FC-1271a-d4

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Cancer
    Ospemifene-d4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active estrogen receptor modulator for the prevention of osteoporosis with IC50 values of 827 nM and 1633 nM for estrogen receptor α (ERα) and ERβ, respectively. Ospemifene has bone-sparing, antitumor, and cholesterol-lowering effects .
    Ospemifene-d4
  • HY-100253
    TA-7552

    		Acyltransferase Cardiovascular Disease
    TA-7552 is a potent cholesterol-lowering agent.
    TA-7552
  • HY-153451
    PCSK9-IN-15

    		PCSK9 Metabolic Disease
    PCSK9-IN-15 (compound 5) is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (PCSK9, KD <200 nM). PCSK9 is involved in cholesterol metabolism and regulates levels of low-density lipoprotein cholesterol (LDL-C) in the blood. PCSK9- in -15 can be used to study cholesterol-lowering and dyslipidemia .
    PCSK9-IN-15
  • HY-16166
    Dalvastatin

    RG-12561

    		 HMG-CoA Reductase (HMGCR) Inflammation/Immunology
    Dalvastatin (RG-12561) inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis .
    Dalvastatin
  • HY-117760
    Spirolaxine

    		Bacterial Endogenous Metabolite Infection
    Spirolaxine is a plant growth inhibitor and possess significant anti-Helicobacter pylori activity. Spirolaxine exhibits cholesterol-lowering activity .
    Spirolaxine
  • HY-16109
    BMS-188494

    		CETP Metabolic Disease
    BMS-188494 is a cholesterol-lowering agent that degrades into a monoester form, BMS-188494, and a free acid form, BMS-187745 .
    BMS-188494
  • HY-N0131S1
    Stigmasterol-d5-1

    Stigmasterin-d5-1

    		 Isotope-Labeled Compounds MMP Endogenous Metabolite Inflammation/Immunology
    Stigmasterol-d5-1 is deuterium labeled Stigmasterol. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases .
    Stigmasterol-d5-1
  • HY-W740341
    3-Pyridinemethanol-d6

    		Isotope-Labeled Compounds CETP Metabolic Disease
    3-Pyridinemethanol-d6 is the deuterium labeled 3-Pyridinemethanol (HY-B0893). 3-Pyridinemethanol (Nicotinyl alcohol), a pyridine derivative, is a cholesterol-lowering agent .
    3-Pyridinemethanol-d6
  • HY-B0893R
    3-Pyridinemethanol (Standard)

    Nicotinyl alcohol (Standard); Pyridine-3-carbinol (Standard)

    		 CETP Reference Standards Metabolic Disease
    3-Pyridinemethanol (Standard) is the analytical standard of 3-Pyridinemethanol. This product is intended for research and analytical applications. 3-Pyridinemethanol (Nicotinyl alcohol), a pyridine derivative, is a cholesterol-lowering agent. 3-Pyridinemethanol can be selectively oxidized to vitamin B3 .
    3-Pyridinemethanol (Standard)
  • HY-N8425R
    Octacosanoic acid (Standard)

    Montanic acid (Standard)

    		 Reference Standards Endogenous Metabolite Metabolic Disease
    Octacosanoic acid (Standard) is the analytical standard of Octacosanoic acid. This product is intended for research and analytical applications. Octacosanoic acid is a very long-chain saturated fatty acid. It is the major component of D-003, a mixture of very long-chain aliphatic acids purified from sugar cane wax that has antiplatelet and cholesterol-lowering activities in animal models .
    Octacosanoic acid (Standard)
  • HY-19201
    Axitirome

    CGS 26214

    		 Thyroid Hormone Receptor Metabolic Disease
    Axitirome (CGS 26214) is a potent, liverselective TRβ receptor agonist and thyromimetic agent. Axitirome has demonstrated cholesterol-lowering activity .
    Axitirome
  • HY-117459
    E-3030 free acid

    		PPAR Metabolic Disease
    E-3030 free acid is a potent dual activator of peroxisome proliferator-activated receptor (PPAR) alpha and PPARgamma, exhibiting significant antidiabetic and lipid-modulating effects. E-3030 decreases blood glucose, triglyceride, non-esterified fatty acids, and insulin levels, while increasing blood adiponectin levels. E-3030 improves glucose tolerance and shows remarkable triglyceride- and non-high-density lipoprotein cholesterol-lowering effects in animal models.
    E-3030 free acid
  • HY-128749AR
    D-Glucaric acid tetrahydrate (Standard)

    Calcium D-glucarate tetrahydrate (Standard)

    		 Endogenous Metabolite Reference Standards Apoptosis Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    D-Glucaric acid tetrahydrate (Standard) (Calcium D-glucarate tetrahydrate (Standard)) is the analytical standard of D-Glucaric acid tetrahydrate (HY-128749A). This product is intended for research and analytical applications. D-Glucaric acid tetrahydrate (Calcium D-glucarate tetrahydrate) is an orally active end product of the mammalian D-glucuronidation pathway. D-Glucaric acid tetrahydrate is found in a variety of fruits and vegetables. D-Glucaric acid tetrahydrate induces cell Apoptosis. D-Glucaric acid tetrahydrate reduces the expression of hippocampal myelin-related genes (Mbp, Plp1). D-Glucaric acid tetrahydrate has cholesterol-lowering and anti-tumor activities. D-Glucaric acid tetrahydrate can be used in the research of neurological diseases .
    D-Glucaric acid tetrahydrate (Standard)
  • HY-P10906
    Talovirtide

    		Biochemical Assay Reagents Others
    Talovirtide is a peptide containing L-valyl .
    Talovirtide
  • HY-P11455
    Lipopeptide CPE4

    		Liposome Others
    Lipopeptide CPE4 is a PEG-modified peptide E4 [(EIAALEK) 4]. Lipopeptide CPE4 is capable of coiled-coil formation when attached to liposomes. Lipopeptide CPE4 triggers membrane fusion between liposomes and living cells with concomitant efficient cytosolic delivery of a variety of compounds such as fluorescent dyes Propidium Iodide (PI) (HY-D0815) and TO-PRO-3 iodide (HY-117070), and Doxorubicin (DOX) (HY-15142A). Lipopeptide CPE4 can be used for drug delivery research .
    Lipopeptide CPE4
  • HY-P10872
    P315V3

    		SARS-CoV Infection
    P315V3 is an pan inhibitor for coronavirus, that inhibits SARS-CoV-2 prototypePT, Delta, BA.1 and BA.4 strain with IC50s of 10.9, 8.9, 8.6, and 2.7 nM. P315V3 exhibits cytotoxicity in Vero cell with CC50 of 4.3 μM. P315V3 exhibits anti-infectious efficacy in mouse models .
    P315V3
  • HY-N1459S
    (24Rac)-Campesterol-d7

    (24Rac)-5-Ergosten-3β-ol-d7

    		 Endogenous Metabolite Cancer
    Campesterol-d7 ((24R)-5-Ergosten-3β-ol-d7) is the deuterium labeled Campesterol. Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.
    (24Rac)-Campesterol-d7
  • HY-107176
    (E)-Hyzetimibe

    (E)-HS-25

    		 Drug Isomer HCV Acyltransferase Infection Metabolic Disease
    (E)-Hyzetimibe ((E)-HS-25) (Compound I-1Z) is the trans isomer of Hyzetimibe (HY-107176A), a cholesterol-lowering agent. (E)-Hyzetimibe has cholesterol acyltransferase (ACTA) inhibitory activity, but its cholesterol-lowering effect is relatively weak. (E)-Hyzetimibe can inhibit the entry of hepatitis C virus (HCV) into host cells, and it has a synergistic effect when used in combination with interferon-α. (E)-Hyzetimibe can be used for the study of HCV infection .
    (E)-Hyzetimibe
  • HY-19107
    SQ-33600

    		HMG-CoA Reductase (HMGCR) Metabolic Disease Endocrinology
    SQ-33600 is an HMG-CoA reductase inhibitor. SQ-33600 has cholesterol-lowering activity. SQ-33600 possesses cell-type selectivity, with much higher inhibitory activity on rat hepatocytes (IC50: 93 nM) than on human skin fibroblasts (IC50: 14200 nM). SQ-33600 can be used in the research of diseases such as hypercholesterolemia .
    SQ-33600
  • HY-171823
    PROTAC HMGCR Degrader-1

    		PROTACs HMG-CoA Reductase (HMGCR) Metabolic Disease
    PROTAC HMGCR Degrader-1 is an orally active HMGCR PROTAC degrader with IC50 of 1.32 μM. PROTAC HMGCR Degrader-1 is a lactone prodrug of PROTAC HMGCR Degrader-2 (HY-181134). PROTAC HMGCR Degrader-1 achieves high plasma exposure of the active ingredient leading to robust HMGCR degradation and demonstrating promising cholesterol-lowering efficacy in vivo. PROTAC HMGCR Degrader-1 can be used for hyperlipidemia research .
    PROTAC HMGCR Degrader-1
  • HY-180457
    GR 92549

    		HMG-CoA Reductase (HMGCR) Cardiovascular Disease Metabolic Disease
    GR 92549 is a potent, orally active, and competitive HMG-CoA reductase inhibitor, can be used as a cholesterol lowering agent .
    GR 92549

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