138330-18-4
Chemical Structure
Incadronate disodium
Synonym(s): YM 175; Bisphonal
- CAS No.: 138330-18-4
- Formula:C8H17NNa2O6P2
- Molecular Weight:331.15
IUPAC Name: ((cycloheptylamino)methylene)diphosphonic acid, disodium salt
InChIKey: PCSJAAWOSGCAFV-UHFFFAOYSA-N
SMILES: O=P(C(P(O)(O[Na])=O)NC1CCCCCC1)(O[Na])O
Biological Activity: Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (Ki=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC50=64 μM). Incadronate disodium has the potential for malignant tumors research[1][2][3].
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Incadronate disodium | Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (Ki=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC50=64 μM). Incadronate disodium has the potential for malignant tumors research. | |||||||||||||||||||||
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References
- [1]. Y Nagao, et al. YM175, a new bisphosphonate, increases serum 1,25-dihydroxyvitamin D in rats via stimulating renal 1-hydroxylase activity. Biochem Biophys Res Commun. 1991 Nov 14;180(3):1172-8. [Content Brief]
- [2]. D Amin, et al. Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis. J Lipid Res. 1992 Nov;33(11):1657-63. [Content Brief]
- [3]. K Takahashi, et al. Effects of YM175, a new-generation bisphosphonate, on hypercalcemia induced by tumor-derived bone resorbing factors in rats. Jpn J Pharmacol. 1998 Feb;76(2):155-63. [Content Brief]
