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cyclin E1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CDK (11) Akt (1) Androgen Receptor (1) Apoptosis (3) Autophagy (1) c-Myc (1) DNA/RNA Synthesis (1) Epigenetic Reader Domain (1) GSK-3 (1) HSP (1) IFNAR (1) Molecular Glues (1) PROTACs (1) SARS-CoV (1) Sirtuin (1)
By Research Areas:	Cancer (11) Infection (1) Metabolic Disease (1)

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Natural
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Recombinant Proteins

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Targets Recommended: E1/E2/E3 Enzyme CDK Cyclin G-associated Kinase (GAK) CDKL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137894A

Tagtociclib hydrate 4 Publications Verification PF-07104091 hydrate	CDK GSK-3	Cancer
PF-07104091 hydrate is a potent and selective CDK2/cyclin E₁ and GSK3β inhibitor, with K_is of 1.16 and 537.81 nM, respectively. PF-07104091 hydrate has anti-tumor activity for cyclin E₁-amplified cancers. (patent WO2020157652A2).

HY-172085

SH514	IFNAR DNA/RNA Synthesis c-Myc CDK	Cancer
SH514 is an orally active IRF4 inhibitor (IC₅₀ = 2.63 μM). SH514 binds to the IRF4-DBD domain, thereby inhibiting the interaction of IRF4 protein with DNA (KD = 1.28 μM). SH514 can inhibit the proliferation of IRF4-high-expressing NCI-H929 and MM.1R cells, and displays no cytotoxicity for normal cells. SH514 significantly downregulates the expression of IRF4 downstream target genes concentration-dependently. SH514 inhibits the expression of cell cycle-related proteins CDC2, Cyclin B1, Cyclin D1, Cyclin E1, and CMYC in Multiple Myeloma cells. SH514 can induce DNA damage and increase the expression of γH2AX. SH514 effectively inhibits the proliferation of multiple myeloma tumors .

HY-164827

CDK2 degrader 3	Molecular Glues CDK	Cancer
CDK2 degrader 3 is a selective CDK2 molecular glue-like degrader. CDK2 degrader 3 induces G1 cell cycle arrest in CCNE1-amplified cancer cells. CDK2 degrader 3 is applicable to breast cancer-related research .

HY-N3389

Licoisoflavone A 2 Publications Verification	SARS-CoV Sirtuin CDK Apoptosis	Infection Metabolic Disease Cancer
Licoisoflavone A is an orally active isoflavone. Licoisoflavone A inhibits proliferation, induces apoptosis, and causes G1/S phase arrest in colorectal cancer (CRC) cells. Licoisoflavone A inhibits the *CDK2-Cyclin* E1 axis. Licoisoflavone A inhibits lipid peroxidation with an IC₅₀ of 7.2 μM. Licoisoflavone A shows a dose-dependent inhibition effect on SARS-CoV-2 infection. Licoisoflavone A exhibits significant anti-tumor efficacy in mice bearing CT26 cell subcutaneous xenografts. Licoisoflavone A can be used for the study of colorectal cancer and SARS-CoV-2 infection .

HY-170897

CDK2-IN-40	CDK	Cancer
CDK2-IN-40 is a *CDK2 (Cyclin* dependent kinase 2) inhibitor, extracted from patent WO 2024/254245 A1 (Example 1). CDK2-IN-40 inhibits CDK2**/Cyclin E1 with an IC₅₀ of ≤ 10 nM .

HY-160643

CDK2-IN-27	CDK	Cancer
CDK2-IN-27 (compound 1) is a potent CDK2 inhibitor with IC₅₀ values of <10, >10-20 nM for CDK2/cyclin E1, CDK2/cyclin B1, respectively .

HY-185164

Anticancer agent 302	CDK	Cancer
Anticancer agent 302 (Example 1) is an anticancer agent. Anticancer agent 302 has a DC₅₀ value of 199 nM for Cyclin E1 and an IC₅₀ value of 133 nM for pRB. Anticancer agent 302 can be used for tumor research .

HY-183273

BRD4/AKT-IN-1	Epigenetic Reader Domain Akt CDK Autophagy Apoptosis	Cancer
BRD4/AKT-IN-1 is a BRD4/AKT inhibitor with BRD4 IC₅₀ 66.12 nM and AKT1 IC₅₀ 143.81 nM. BRD4/AKT-IN-1 blocks BRD4-mediated c-Myc transcriptional regulation, modulates AKT1 signaling, decouples AKT phosphorylation from pro-survival effectors. BRD4/AKT-IN-1 induces G0/G1 cell cycle arrest via downregulated phosphorylated RB, cyclin E1, CDK2. BRD4/AKT-IN-1 elevates LC3B levels to promote autophagy. BRD4/AKT-IN-1 promotes apoptosis in cancer cells. BRD4/AKT-IN-1 can be used for the research of metastatic castration-resistant prostate cancer .

HY-181727

AR/AR-V7 degrader-1	Androgen Receptor HSP CDK	Cancer
AR/AR-V7 degrader-1 is an orally active AR and AR-V7 degrader. AR/AR-V7 degrader-1 disrupts the interaction between AR/AR-V7 and HSP90, leading to their ubiquitination and degradation in castration-resistant prostate cancer cells. AR/AR-V7 degrader-1 regulates the expression of cell cycle-related proteins in prostate cancer cells (downregulates CDK4, CDK6, Cyclin D1, Cyclin E1; upregulates P21) and induces G0/G1 phase arrest. AR/AR-V7 degrader-1 inhibits the proliferation and migration of prostate cancer cells. AR/AR-V7 degrader-1 suppresses the growth of castration-resistant prostate cancer tumors in nude mice and induces the degradation of AR and AR-V7 in tumor tissues. AR/AR-V7 degrader-1 is applicable to the research of castration-resistant prostate cancer .

HY-181130

Anticancer agent 299	CDK Apoptosis	Cancer
Anticancer agent 299 (compound P12) is a cell-cycle inhibitor, senescence inducer, apoptosis inducer, and antiproliferative agent. Anticancer agent 299 exhibits selective activity against cancer cells with minimal effects on non-tumoral chondrocyte cells at relevant concentrations. Anticancer agent 299 can be used for the research of ER+/HER2− breast cancer and BRAF-mutant melanoma .

HY-186132

PROTAC CDK2-pRb degrader-1	PROTACs CDK	Cancer
PROTAC CDK2-pRb degrader-1 is an orally active PROTAC-class degrader of CDK2. PROTAC CDK2-pRb degrader-1 effectively inhibits the phosphorylation of retinoblastoma protein (Rb) at serine residues 807/811 by inducing ubiquitination and proteasomal degradation of CDK2. PROTAC CDK2-pRb degrader-1 exhibits significant activity against human cells (with EC₅₀ values of 12 nM and 125 nM, respectively). In xenograft models, PROTAC CDK2-pRb degrader-1 effectively inhibits tumor growth and induces tumor stasis, making it suitable for research related to CCNE1-amplified cancers (such as ovarian cancer, gastric cancer, and breast cancer) .

Licoisoflavone A 2 Publications Verification	Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Source Classification	SARS-CoV Sirtuin CDK Apoptosis
Licoisoflavone A is an orally active isoflavone. Licoisoflavone A inhibits proliferation, induces apoptosis, and causes G1/S phase arrest in colorectal cancer (CRC) cells. Licoisoflavone A inhibits the *CDK2-Cyclin* E1 axis. Licoisoflavone A inhibits lipid peroxidation with an IC₅₀ of 7.2 μM. Licoisoflavone A shows a dose-dependent inhibition effect on SARS-CoV-2 infection. Licoisoflavone A exhibits significant anti-tumor efficacy in mice bearing CT26 cell subcutaneous xenografts. Licoisoflavone A can be used for the study of colorectal cancer and SARS-CoV-2 infection .

Species:	Human (7) Mouse (1)
Tag:	His (6) Tag Free (2) GST (6) Flag (3)
Source:	Sf9 insect cells (8)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74214

	Cyclin E Protein, Human (sf9) CCNE; CCNE1; cyclin E1; G1/S-specific cyclin-E1	Human	Sf9 insect cells
	Cyclin E controls the G1/S transition of the cell cycle. Cyclin E Protein, Human (sf9) is the recombinant human-derived Cyclin E, expressed by Sf9 insect cells , with tag Free labeled tag.

HY-P72963

	Cyclin E Protein, Human (sf9, His-GST) CCNE; CCNE1; CCNEcyclin Es; cyclin E1; G1/S-specific cyclin-E1	Human	Sf9 insect cells
	Cyclin E controls the G1/S transition of the cell cycle. Cyclin E Protein, Human (SF9, His-GST) is the recombinant human-derived Cyclin E protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P72964

	Cyclin E Protein, Mouse (sf9, His-GST) CCNE; CCNE1; CCNEcyclin Es; cyclin E1; G1/S-specific cyclin-E1	Mouse	Sf9 insect cells
	Cyclin E, a vital regulator in cell cycle control, governs the G1/S transition by forming a potent serine/threonine kinase complex with CDK2. This complex, featuring UHRF2, CDK2, and CCNE1, involves Cyclin E's direct interaction with UHRF2, leading to CCNE1 ubiquitination independently of phosphorylation. Cyclin E's intricate dance with CDK2, CABLES1, and CCNA1 highlights its crucial role in tightly regulated cell cycle progression. Cyclin E Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Cyclin E protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P74257

	CDK1-CCNE1 Heterodimer Protein, Human (Inactive, sf9, His-GST) cyclin-dependent kinase 1; CDK1; CDC2; G1/S-specific cyclin-E1; CCNE1	Human	Sf9 insect cells
	The FGF-9 protein undergoes autoproteolysis and cholesterol attachment in the endoplasmic reticulum. It acts as a morphogen during development, inducing ventral cell fate, participating in limb bud patterning, and aiding in axon guidance. FGF-9 binds to the PTCH1 receptor and activates target gene transcription when in association with SMO, while PTCH1 represses SMO signaling in the absence of FGF-9. CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST) is a recombinant protein dimer complex containing human-derived CDK1-CCNE1 Heterodimer protein, expressed by Sf9 insect cells , with N-10*His, N-GST labeled tag. CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST), has molecular weight of ~109.7 (60.4+49.3) kDa.

HY-P701364

	CDK3-CCNE1 Heterodimer Protein, Human (sf9) CDK3; CCNE1; cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1	Human	Sf9 insect cells
	CDK3 protein is a serine/threonine protein kinase that plays a key role in regulating the eukaryotic cell cycle, especially affecting the G0-G1 and G1-S transitions. It interacts with CCNC/cyclin-C during interphase and phosphorylates substrates such as histone H1, ATF1, RB1, and CABLES1. CDK3-CCNE1 Heterodimer Protein, Human (sf9) is a recombinant protein dimer complex containing human-derived CDK3-CCNE1 Heterodimer protein, expressed by sf9 insect cells , with tag free.

HY-P702680

	CDK3-CCNC Protein, Human (Active, sf9, GST, Flag, His) CDK3; CCNE1; cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1	Human	Sf9 insect cells
	CDK3 protein is a serine/threonine protein kinase that plays a key role in regulating the eukaryotic cell cycle, especially affecting the G0-G1 and G1-S transitions. It interacts with CCNC/cyclin-C during interphase and phosphorylates substrates such as histone H1, ATF1, RB1, and CABLES1. CDK3-CCNC Protein, Human (Active, sf9, GST, Flag, His) is the recombinant human-derived CDK3-CCNC, expressed by Sf9 insect cells, with N-Flag, N-His, N-GST labeled tag.

HY-P702681

	CDK3-CCNE2 Protein, Human (sf9, GST, Flag, His) CDK3; CCNE1; cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1	Human	Sf9 insect cells
	CDK3 protein is a serine/threonine protein kinase that plays a key role in regulating the eukaryotic cell cycle, especially affecting the G0-G1 and G1-S transitions. It interacts with CCNC/cyclin-C during interphase and phosphorylates substrates such as histone H1, ATF1, RB1, and CABLES1. CDK3-CCNE2 Protein, Human (sf9, GST, Flag, His) is the recombinant human-derived CDK3-CCNE2, expressed by Sf9 insect cells, with N-His, N-GST, N-Flag labeled tag.

HY-P701365

	CDK3-CCNE1 Heterodimer Protein, Human (Active, sf9, GST, FLAG, His) CDK3; CCNE1; cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1	Human	Sf9 insect cells
	CDK3 protein is a serine/threonine protein kinase that plays a key role in regulating the eukaryotic cell cycle, especially affecting the G0-G1 and G1-S transitions. It interacts with CCNC/cyclin-C during interphase and phosphorylates substrates such as histone H1, ATF1, RB1, and CABLES1. CDK3-CCNE1 Heterodimer Protein, Human (sf9, GST, FLAG, His) is a recombinant protein dimer complex containing human-derived CDK3-CCNE1 Heterodimer protein, expressed by sf9 insect cells , with N-6*His, N-Flag, N-GST labeled tag.

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Host:	Mouse (2) Rabbit (4)
Reactivity:	Human (6) Rat (2) Mouse (3)
Application:	IHC-P (5) ICC/IF (3) IP (1) IHC-F (1) WB (4) FC (2) ELISA (4)
Isotype:	IgG (4) IgG1 (2)
Conjugation:	Non-conjugated (6)
Clonality:	Polyclonal (2) Monoclonal (2) Monoclonal Antibody (1) Recombinant (1)
Modification:	Phosphorylated (1) Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80100

	Cyclin E1 Antibody (YA483)	WB, ICC/IF, IHC-P	Human, Mouse
	Cyclin E1 Antibody (YA483) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclin E1.

HY-P84205

	Cyclin E1 Antibody (YA3902) CCNE; PccnE1	IHC-P, FC, ELISA	Human
	Cyclin E1 Antibody (YA3902) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cyclin E1.

HY-P80635

	Cyclin E1 Antibody 1 Publications Verification CCNE1; CCNE; G1/S-specific cyclin-E1	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Cyclin E1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Cyclin E1.

HY-P86624

	Cyclin E1 Antibody (YA6316) CCNE1; CCNE; G1/S-specific cyclin-E1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Cyclin E1 Antibody (YA6316) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cyclin E1.

HY-P84205A

	Cyclin E1 Antibody (YA3902)(PBS only) CCNE; PccnE1	IHC-P, FC, ELISA	Human
	Cyclin E1 Antibody (YA3902) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Cyclin E1.

HY-P80807

	*Phospho-Cyclin* E1 (Thr395) Antibody** CCNE1; CCNE; G1/S-specific cyclin-E1	WB	Human
	Phospho-Cyclin E1 (Thr395) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-Cyclin E1 (Thr395).

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cyclin E1

Inhibitors & Agonists

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Recombinant Proteins

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