Search Result

Results for "

deformylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (4) Antibiotic (5) Apoptosis (2) Bacterial (11) Biochemical Assay Reagents (1) Formyl Peptide Receptor (FPR) (6) Influenza Virus (1) Mitochondrial Metabolism (1) MMP (3) Neurokinin Receptor (1) Reference Standards (1) TNF Receptor (2)
By Research Areas:	Cancer (5) Infection (14) Inflammation/Immunology (5) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0224

*N-Formyl-Met-Leu-Phe* 15+ Cited Publications fMLP; N-Formyl-MLF	TNF Receptor	Inflammation/Immunology
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.

HY-113952

Actinonin 5+ Cited Publications (-)-Actinonin	Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Infection Cancer
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible *peptide deformylase* (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis** inducer. Actinonin has antiproliferative and antitumor activities .

HY-118694

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .

HY-135108

QWF Peptide	Neurokinin Receptor	Neurological Disease
QWF Peptide (Compound 4a) is a substance P antagonist with an IC₅₀ of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC₅₀ of 4.7 μM .

HY-P1744

*N-Formyl-Met-Leu-Phe-Lys* fMLFK	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Met-Leu-Phe-Lys (fMLFK) is a peptide, acts as a potent and selective agonist of FPR1, with EC₅₀s of 3.5 nM, 6.7 μM and 0.88 μM for FPR1, FPR2 and FPR2-D281 ^7.32G, respectively .

HY-P10738

*N-Formyl-MMYALF*	Formyl Peptide Receptor (FPR)	Infection
N-Formyl-MMYALF is a potent mitochondrial N-formyl peptide (mtFP) that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF can inhibit the FPR-1-mediated chemotactic response of polymorphonuclear leukocytes (PMNs) to bacterial peptides .

HY-P1591

*N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys* For-Nle-Leu-Phe-Nle-Tyr-Lys-OH	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist .

HY-P1756

*N-Formyl-Met-Ala-Ser*	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Met-Ala-Ser is a peptide, binds to formyl peptide receptors on neutrophils.

HY-102009

BB-83698	Bacterial	Infection
BB-83698 is a peptide deformylase (PDF) inhibitor. BB-83698 exhibits potent in vitro activity against Streptococcus pneumoniae, with a minimum inhibitory concentration (MIC) range of 0.06-0.25μg/mL. BB-83698 elevates the survival rate of mice regardless of whether the infecting strain carries resistance mechanisms. BB-83698 can be used for the study of diseases related to drug-resistant Streptococcus pneumoniae infections .

HY-102008

LBM-415 NVP-PDF 713; VIC-104959	Bacterial Antibiotic	Infection
LBM-415 (NVP-PDF 713) is a peptide deformylase (PDF) inhibitor that exhibits inhibitory activity against various antimicrobial-resistant gram-positive cocci, with a MIC₉₀ range of 0.12-8 µg/ml. Additionally, inhibiting efflux pump activity can enhance bacterial sensitivity to LBM415, thereby improving its antibacterial efficacy .

HY-114900

BB-3497	Antibiotic	Infection Others
BB-3497 is a potent, orally active and selective peptide deformylase (PDF) inhibitor. BB-3497 is highly selective for PDF (IC₅₀ = 7 nM for E. coli PDF.Ni) over the other mammalian metalloenzymes (MMP-1/2/3/7 and enkephalinase). BB-3497 exhibits potent activity against gram-positive bacteria and some gram-negative pathogens. BB-3497 protects mice from infection in systemic models of Staphylococeus aureus. BB-3497 can be used for anti-bacterial infection research .

HY-177301

PDF-IN-2	Bacterial	Infection
PDF-IN-2 is a peptidyl deformylase (PDF) inhibitor. PDF-IN-2 has average IC₅₀ values of 0.25, 0.50 and 0.34 nM, and average MIC values of 0.16, 0.33 and 0.25 μg/mL for Streptococcus pneumoniae PDF WT, G70V and G70D, respectively. PDF-IN-2 can be used in the research of infectious diseases .

HY-113952R

Actinonin (Standard) (-)-Actinonin (Standard)	Reference Standards Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Infection Cancer
Actinonin (Standard) is the analytical standard of Actinonin. This product is intended for research and analytical applications. Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].

HY-121610

FR-202306	Bacterial Antibiotic	Others
FR-202306 is a compound with antibacterial and peptide deformylase inhibitory activities, isolated from microorganisms, which has an inhibitory effect on the peptide deformylase of Staphylococcus aureus and also has antibacterial activity.

HY-148372

For-Met-Leu-pNA	Biochemical Assay Reagents	Cancer
For-Met-Leu-pNA is an N-formylated peptide substrate that can be used in the deformylase assays .

HY-122097

M7594_0037	Mitochondrial Metabolism	Cancer
M7594_0037 is a potent inhibitor of human peptide deformylase (HsPDF) that has anti-tumor activity .

HY-113753

PDF-IN-1	Bacterial	Infection
PDF-IN-1 (compound 2) is a potential Peptide deformylase (PDF) inhibitor. PDF-IN-1 can be used for the development of new broad-spectrum antibiotics .

HY-168853

Antibacterial agent 261	Bacterial	Infection
Antibacterial agent 261 (compound 43) is a potent inhibitor of *peptidomimetic peptide deformylase* (PDF), with IC₅₀** of 2.5 and 10.6 nM for S. aureus and E. coli, respectively .

HY-119728

FR198248	Influenza Virus	Infection
FR198248 is an anti-influenza agent and peptide deformylase (PDF) inhibitor. FR198248 can be isolated from Aspergillus flavipes. FR198248 potently inhibits the PDF of Staphylococcus aureus with an IC₅₀ of 3.6 µM. FR198248 can be used for antiviral and antibacterial research .

HY-P10738A

*N-Formyl-MMYALF TFA*	Formyl Peptide Receptor (FPR)	Infection
N-Formyl-MMYALF TFA is a mitochondrial N-formyl peptide that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF TFA can inhibit the FPR-1-mediated chemotactic response of PMNs to bacterial peptides .

HY-P1591A

*N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA* For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist .

HY-182256

Lanopepden camsylate GSK1322322 camsylate	Aminopeptidase Bacterial	Infection
Lanopepden camsylate (GSK1322322 camsylate) is a high-affinity bacterial peptide deformylase inhibitor. Lanopepden camsylate is applicable to research related to bacterial infections .

HY-181674

ZHO-197	Aminopeptidase Bacterial	Infection
ZHO-197 is a dual bacterial peptide deformylase and methionine aminopeptidase inhibitor with antibacterial activity. ZHO-197 exhibits an Escherichia coli peptide deformylase IC₅₀ of 0.021 μM and a human peptide deformylase IC₅₀ of 3.289 μM. ZHO-197 displays broad-spectrum antibacterial activity against gram-positive and gram-negative bacterial strains. ZHO-197 can be used for the research of bacterial infection .

*N-Formyl-Met-Leu-Phe* 15+ Cited Publications fMLP; N-Formyl-MLF	TNF Receptor	Inflammation/Immunology
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .

QWF Peptide	Neurokinin Receptor	Neurological Disease
QWF Peptide (Compound 4a) is a substance P antagonist with an IC₅₀ of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC₅₀ of 4.7 μM .

*N-Formyl-Met-Leu-Phe-Lys* fMLFK	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Met-Leu-Phe-Lys (fMLFK) is a peptide, acts as a potent and selective agonist of FPR1, with EC₅₀s of 3.5 nM, 6.7 μM and 0.88 μM for FPR1, FPR2 and FPR2-D281 ^7.32G, respectively .

*N-Formyl-MMYALF*	Formyl Peptide Receptor (FPR)	Infection
N-Formyl-MMYALF is a potent mitochondrial N-formyl peptide (mtFP) that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF can inhibit the FPR-1-mediated chemotactic response of polymorphonuclear leukocytes (PMNs) to bacterial peptides .

*N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys* For-Nle-Leu-Phe-Nle-Tyr-Lys-OH	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist .

*N-Formyl-Met-Ala-Ser*	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Met-Ala-Ser is a peptide, binds to formyl peptide receptors on neutrophils.

*N-Formyl-MMYALF TFA*	Formyl Peptide Receptor (FPR)	Infection
N-Formyl-MMYALF TFA is a mitochondrial N-formyl peptide that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF TFA can inhibit the FPR-1-mediated chemotactic response of PMNs to bacterial peptides .

*N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA* For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113952

Actinonin 5+ Cited Publications (-)-Actinonin	Infection Natural Products Microorganisms Classification of Application Fields Marine natural products Disease Research Fields Source Classification	Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible *peptide deformylase* (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis** inducer. Actinonin has antiproliferative and antitumor activities .

HY-113952R

Actinonin (Standard) (-)-Actinonin (Standard)	Natural Products Microorganisms Source Classification	Reference Standards Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin (Standard) is the analytical standard of Actinonin. This product is intended for research and analytical applications. Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].

HY-119728

FR198248	Microorganisms Phenols Polyphenols Source Classification	Influenza Virus
FR198248 is an anti-influenza agent and peptide deformylase (PDF) inhibitor. FR198248 can be isolated from Aspergillus flavipes. FR198248 potently inhibits the PDF of Staphylococcus aureus with an IC₅₀ of 3.6 µM. FR198248 can be used for antiviral and antibacterial research .

Species:	Staphylococcus aureus (2)
Tag:	SUMO (1) His (2)
Source:	P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71767

	*Peptide deformylase* Protein, S. aureus (P.pastoris, His)** def; def1; pdf1Peptide deformylase; PDF; Polypeptide deformylase	Staphylococcus aureus	P. pastoris
	Peptide deformylase, a crucial enzyme in protein biosynthesis, catalyzes the removal of the formyl group from the N-terminal methionine of newly synthesized proteins. Displaying broad specificity at positions beyond the N-terminal L-methionine, the enzyme ensures proper maturation and functionality of proteins, emphasizing its essential contribution to the intricate process of protein synthesis and modification. Peptide deformylase Protein, S. aureus (P.pastoris, His) is the recombinant Staphylococcus aureus-derived Peptide deformylase protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P703505

	*Peptide deformylase* Protein, S. aureus (His, SUMO)** def; def1; pdf1Peptide deformylase; PDF; EC 3.5.1.88; Polypeptide deformylase	Staphylococcus aureus	E. coli
	Peptide deformylase, a crucial enzyme in protein biosynthesis, catalyzes the removal of the formyl group from the N-terminal methionine of newly synthesized proteins. Displaying broad specificity at positions beyond the N-terminal L-methionine, the enzyme ensures proper maturation and functionality of proteins, emphasizing its essential contribution to the intricate process of protein synthesis and modification. Peptide deformylase Protein, S. aureus (His, SUMO) is the recombinant staphylococcus aureus-derived Peptide deformylase protein, expressed by E. coli, with SUMO and N-6*His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

deformylase

Inhibitors & Agonists

Peptides

NaturalProducts

Recombinant Proteins

Natural
Products