27 Results for "

deformylase

" in MedChemExpress (MCE) Product Catalog:
Products (27)

27 Results for "deformylase" in MCE Product Catalog:

16
16 Cited Publications
Cat. No.: HY-P0224
CAS No.: 59880-97-6
Synonyms: fMLP; N-Formyl-MLF
Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.
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7
7 Cited Publications
Cat. No.: HY-113952
CAS No.: 13434-13-4
Purity:  98.37%
Synonyms: (-)-Actinonin
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .
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Cat. No.: HY-118694
CAS No.: 163958-73-4
Purity:  98.98%
Target:  

TNF Receptor MMP Bacterial

Research Areas:  

Infection Cancer

TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .
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Cat. No.: HY-135108
CAS No.: 126088-82-2
Purity:  98.15%
Target:  

Neurokinin Receptor

Research Areas:  

Inflammation/Immunology

QWF Peptide is a substance P (SP) antagonist. QWF Peptide inhibits SP-induced biological responses and also suppresses SP-induced contraction of isolated guinea pig tracheal strips. QWF Peptide can be used for asthma-related research .
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Cat. No.: HY-P1744
CAS No.: 67247-11-4
Synonyms: fMLFK
Research Areas:  

Inflammation/Immunology

N-Formyl-Met-Leu-Phe-Lys (fMLFK) is a peptide, acts as a potent and selective agonist of FPR1, with EC50s of 3.5 nM, 6.7 μM and 0.88 μM for FPR1, FPR2 and FPR2-D281 7.32G, respectively .
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Cat. No.: HY-P10738
CAS No.: 863418-59-1
Research Areas:  

Infection

N-Formyl-MMYALF is a potent mitochondrial N-formyl peptide (mtFP) that has the activity of depleting calcium ions in the endoplasmic reticulum. N-Formyl-MMYALF can inhibit the FPR-1-mediated chemotactic response of polymorphonuclear leukocytes (PMNs) to bacterial peptides .
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Cat. No.: HY-P1591
CAS No.: 71901-21-8
Synonyms: For-Nle-Leu-Phe-Nle-Tyr-Lys-OH
Research Areas:  

Inflammation/Immunology

N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist .
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Cat. No.: HY-12480
CAS No.: 1152107-25-9
Purity:  98.62%
Synonyms: GSK 1322322
Target:  

Bacterial

Research Areas:  

Infection

Lanopepden (GSK 1322322) is a peptide deformylase (PDF) inhibitor. Lanopepden exerts antibacterial activity by inhibiting the activity of PDF and preventing the correct synthesis of bacterial proteins. Lanopepden can be used for the research of acute bacterial skin and skin structure infections .
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Cat. No.: HY-P1756
CAS No.: 17351-32-5
Research Areas:  

Inflammation/Immunology

N-Formyl-Met-Ala-Ser is a peptide, binds to formyl peptide receptors on neutrophils.
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Cat. No.: HY-102009
CAS No.: 325795-25-3
Target:  

Bacterial

Research Areas:  

Infection

BB-83698 is a peptide deformylase (PDF) inhibitor. BB-83698 exhibits potent in vitro activity against Streptococcus pneumoniae, with a minimum inhibitory concentration (MIC) range of 0.06-0.25μg/mL. BB-83698 elevates the survival rate of mice regardless of whether the infecting strain carries resistance mechanisms. BB-83698 can be used for the study of diseases related to drug-resistant Streptococcus pneumoniae infections .
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Cat. No.: HY-102008
CAS No.: 478913-91-6
Synonyms: NVP-PDF 713; VIC-104959
Target:  

Bacterial Antibiotic

Research Areas:  

Infection

LBM-415 (NVP-PDF 713) is a peptide deformylase (PDF) inhibitor that exhibits inhibitory activity against various antimicrobial-resistant gram-positive cocci, with a MIC90 range of 0.12-8 µg/ml. Additionally, inhibiting efflux pump activity can enhance bacterial sensitivity to LBM415, thereby improving its antibacterial efficacy .
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Cat. No.: HY-114900
CAS No.: 235784-88-0
Target:  

Antibiotic

Research Areas:  

Infection Others

BB-3497 is a potent, orally active and selective peptide deformylase (PDF) inhibitor. BB-3497 is highly selective for PDF (IC50 = 7 nM for E. coli PDF.Ni) over the other mammalian metalloenzymes (MMP-1/2/3/7 and enkephalinase). BB-3497 exhibits potent activity against gram-positive bacteria and some gram-negative pathogens. BB-3497 protects mice from infection in systemic models of Staphylococeus aureus. BB-3497 can be used for anti-bacterial infection research .
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Cat. No.: HY-177301
CAS No.: 949197-97-1
Target:  

Bacterial

Research Areas:  

Infection

PDF-IN-2 is a peptidyl deformylase (PDF) inhibitor. PDF-IN-2 has average IC50 values of 0.25, 0.50 and 0.34 nM, and average MIC values of 0.16, 0.33 and 0.25 μg/mL for Streptococcus pneumoniae PDF WT, G70V and G70D, respectively. PDF-IN-2 can be used in the research of infectious diseases .
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Cat. No.: HY-113952R
CAS No.: 13434-13-4
Synonyms: (-)-Actinonin (Standard)
Actinonin (Standard) is the analytical standard of Actinonin. This product is intended for research and analytical applications. Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].
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Cat. No.: HY-121610
CAS No.: 342785-41-5
Target:  

Bacterial

Research Areas:  

Others

FR-202306 is a compound with antibacterial and peptide deformylase inhibitory activities, isolated from microorganisms, which has an inhibitory effect on the peptide deformylase of Staphylococcus aureus and also has antibacterial activity.
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Cat. No.: HY-148372
CAS No.: 111150-07-3
Research Areas:  

Cancer

For-Met-Leu-pNA is an N-formylated peptide substrate that can be used in the deformylase assays .
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Cat. No.: HY-122097
CAS No.: 774551-07-4
Research Areas:  

Cancer

M7594_0037 is a potent inhibitor of human peptide deformylase (HsPDF) that has anti-tumor activity .
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Cat. No.: HY-113753
CAS No.: 900783-19-9
Target:  

Bacterial

Research Areas:  

Infection

PDF-IN-1 (compound 2) is a potential Peptide deformylase (PDF) inhibitor. PDF-IN-1 can be used for the development of new broad-spectrum antibiotics .
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Cat. No.: HY-168853
CAS No.: 3036109-97-1
Target:  

Bacterial

Research Areas:  

Infection

Antibacterial agent 261 (compound 43) is a potent inhibitor of peptidomimetic peptide deformylase (PDF), with IC50 of 2.5 and 10.6 nM for S. aureus and E. coli, respectively .
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Cat. No.: HY-119728
CAS No.: 197316-54-4
FR198248 is an anti-influenza agent and peptide deformylase (PDF) inhibitor. FR198248 can be isolated from Aspergillus flavipes. FR198248 potently inhibits the PDF of Staphylococcus aureus with an IC50 of 3.6 µM. FR198248 can be used for antiviral and antibacterial research .
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