163958-73-4
163958-73-4
Chemical Structure
TAPI-0
- CAS No.: 163958-73-4
- Formula:C24H32N4O5
- Molecular Weight:456.53
IUPAC Name: (R)-N1-((S)-1-(((S)-1-amino-1-oxopropan-2-yl)amino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide
InChIKey: CRCPLBFLOSEABN-BEVDRBHNSA-N
SMILES: ONC(C[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CC1=CC2=C(C=C1)C=CC=C2)=O)CC(C)C)=O
Biological Activity: TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TAPI-0 | 97.06% | TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing. | ||||||||||||||||||||
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References
- [1]. Amit Balakrishnan, et al. Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J Biol Chem. 2006 Jun 16;281(24):16691-9. [Content Brief]
- [2]. Shiori Haga, et al. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res. 2010 Mar;85(3):551-5. [Content Brief]
