235784-88-0
Chemical Structure
BB-3497
- CAS No.: 235784-88-0
- Formula:C16H31N3O4
- Molecular Weight:329.44
IUPAC Name: (R)-N-((S)-1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-2-((N-hydroxyformamido)methyl)hexanamide
InChIKey: AVDLWYHBABSSHC-CHWSQXEVSA-N
SMILES: CCCC[C@@H](C(N[C@@H](C(C)(C)C)C(N(C)C)=O)=O)CN(O)C=O
Biological Activity: BB-3497 is a potent, orally active and selective peptide deformylase (PDF) inhibitor. BB-3497 is highly selective for PDF (IC50 = 7 nM for E. coli PDF.Ni) over the other mammalian metalloenzymes (MMP-1/2/3/7 and enkephalinase). BB-3497 exhibits potent activity against gram-positive bacteria and some gram-negative pathogens. BB-3497 protects mice from infection in systemic models of Staphylococeus aureus. BB-3497 can be used for anti-bacterial infection research[1].
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BB-3497 | BB-3497 is a potent, orally active and selective peptide deformylase (PDF) inhibitor. BB-3497 is highly selective for PDF (IC50 = 7 nM for E. coli PDF.Ni) over the other mammalian metalloenzymes (MMP-1/2/3/7 and enkephalinase). BB-3497 exhibits potent activity against gram-positive bacteria and some gram-negative pathogens. BB-3497 protects mice from infection in systemic models of Staphylococeus aureus. BB-3497 can be used for anti-bacterial infection research. | |||||||||||||||||||||
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Keywords
