478913-91-6
Chemical Structure
LBM-415
Synonym(s): NVP-PDF 713; VIC-104959
- CAS No.: 478913-91-6
- Formula:C18H25FN4O5
- Molecular Weight:396.41
IUPAC Name: 5-fluoro-2-((S)-1-((R)-2-((N-hydroxyformamido)methyl)hexanoyl)pyrrolidine-2-carboxamido)pyridine 1-oxide
InChIKey: LYPFVIYNUQCDPM-HIFRSBDPSA-N
SMILES: O=C([C@H]1N(C([C@@H](CN(C=O)O)CCCC)=O)CCC1)NC2=CC=C(F)C=[N+]2[O-]
Biological Activity: LBM-415 (NVP-PDF 713) is a peptide deformylase (PDF) inhibitor that exhibits inhibitory activity against various antimicrobial-resistant gram-positive cocci, with a MIC90 range of 0.12-8 µg/ml. Additionally, inhibiting efflux pump activity can enhance bacterial sensitivity to LBM415, thereby improving its antibacterial efficacy[1].
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LBM-415 | LBM-415 (NVP-PDF 713) is a peptide deformylase (PDF) inhibitor that exhibits inhibitory activity against various antimicrobial-resistant gram-positive cocci, with a MIC90 range of 0.12-8 µg/ml. Additionally, inhibiting efflux pump activity can enhance bacterial sensitivity to LBM415, thereby improving its antibacterial efficacy. | |||||||||||||||||||||
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Keywords
