1152107-25-9
Chemical Structure
Lanopepden
Synonym(s): GSK 1322322
- CAS No.: 1152107-25-9
- Formula:C22H34FN7O4
- Molecular Weight:479.55
IUPAC Name: N-((R)-2-(cyclopentylmethyl)-3-(2-(5-fluoro-6-((S)-hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-2-methylpyrimidin-4-yl)hydrazinyl)-3-oxopropyl)-N-hydroxyformamide
InChIKey: SWHNZGMQMGFQGW-MSOLQXFVSA-N
SMILES: FC1=C(N2CCN(CCOC3)[C@@]3([H])C2)N=C(C)N=C1NNC([C@H](CC4CCCC4)CN(C=O)O)=O
Biological Activity: Lanopepden (GSK 1322322) is a peptide deformylase (PDF) inhibitor. Lanopepden exerts antibacterial activity by inhibiting the activity of PDF and preventing the correct synthesis of bacterial proteins. Lanopepden can be used for the research of acute bacterial skin and skin structure infections[1][2].
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Lanopepden | 99.9% | Lanopepden (GSK 1322322) is a peptide deformylase (PDF) inhibitor. Lanopepden exerts antibacterial activity by inhibiting the activity of PDF and preventing the correct synthesis of bacterial proteins. Lanopepden can be used for the research of acute bacterial skin and skin structure infections. | ||||||||||||||||||||
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- [1]. Butler MS, et al. A Review of Antibacterial Candidates with New Modes of Action. ACS infectious diseases. 2024 Oct 11;10(10):3440-3474. [Content Brief]
- [2]. Amina M, et al. Theoretical Study of the Interactions Involved in the Inhibition of Staphylococcus aureus Peptide Deformylase by GSK1322322 Derivatives. Journal Academica, 2015, 5(2): 16-29.
Keywords
