1. Membrane Transporter/Ion Channel
  2. TRP Channel

PF-4840154 

Cat. No.: HY-18779 Purity: 99.92%
Handling Instructions

PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.

For research use only. We do not sell to patients.
PF-4840154 Chemical Structure

PF-4840154 Chemical Structure

CAS No. : 1332708-14-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg USD 2520 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively. IC50 value: 97 nM (EC50, for rTrpA1), 23 nM (EC50, for hTrpA1) Target: TrpA1 PF-4840154 is a non-electrophilic reference agonist of the TrpA1 channel. PF-4840154 is initiated to establish its suitability as a reference agonist of the TrpA1 channel.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.1431 mL 10.7154 mL 21.4307 mL
5 mM 0.4286 mL 2.1431 mL 4.2861 mL
10 mM 0.2143 mL 1.0715 mL 2.1431 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

466.62

Formula

C₂₆H₃₈N₆O₂

CAS No.

1332708-14-1

SMILES

O=C(C1=CN=C(N2CCN(CC3COCCC3)CC2)N=C1NCC(C)C)NCC4=CC=CC=C4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.92%

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Product Name:
PF-4840154
Cat. No.:
HY-18779
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