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electric

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (3) Bacterial (1) Biochemical Assay Reagents (2) Calcium Channel (1) Chloride Channel (1) Cholinesterase (ChE) (24) Drug Derivative (2) Factor Xa (2) GABA Receptor (1) Glutathione S-transferase (1) GSK-3 (2) Histamine Receptor (1) HSP (1) Insecticide (3) Isotope-Labeled Compounds (1) Kallikrein (2) mAChR (3) Monoamine Oxidase (3) Potassium Channel (1) Reactive Oxygen Species (ROS) (3) Reference Standards (1) Ser/Thr Protease (2) SOD (1) Tau Protein (1) Thrombin (2)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Infection (4) Inflammation/Immunology (3) Neurological Disease (30)

By Targets:

Amyloid-β (3)

Bacterial (1)

Biochemical Assay Reagents (2)

Calcium Channel (1)

Chloride Channel (1)

Cholinesterase (ChE) (24)

Drug Derivative (2)

Factor Xa (2)

GABA Receptor (1)

Glutathione S-transferase (1)

GSK-3 (2)

Histamine Receptor (1)

HSP (1)

Insecticide (3)

Isotope-Labeled Compounds (1)

Kallikrein (2)

mAChR (3)

Monoamine Oxidase (3)

Potassium Channel (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (1)

Ser/Thr Protease (2)

SOD (1)

Tau Protein (1)

Thrombin (2)

By Research Areas:

Cancer (2)

Cardiovascular Disease (2)

Infection (4)

Inflammation/Immunology (3)

Neurological Disease (30)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2860A

*Acetylcholinesterase, Electric* eel**	Cholinesterase (ChE)	Neurological Disease
Acetylcholinesterase, Electric eel is a cholinergic enzyme that is mainly found in neuromuscular junctions and cholinergic chemical synapses and is often used in biochemical research. Acetylcholinesterase, Electric eel can catalyze the decomposition or hydrolysis of acetylcholine and some other choline esters that act as neurotransmitters into acetic acid and choline. The main function of Acetylcholinesterase, Electric eel is to terminate neuronal transmission and signal conduction between synapses to prevent ACh diffusion and activation of nearby receptors .

HY-W127776

Zn(Ⅱ)-EDTA disodium tetrahydrate Ethylenediaminetetraacetic acid zinc disodium tetrahydrate	Biochemical Assay Reagents	Others
Zn(II)-EDTA (Ethylenediaminetetraacetic acid zinc) disodium tetrahydrate is a coordinating agent. Zn(II)-EDTA disodium tetrahydrate coordinates with Zn ²⁺ to modify its solvated structure, provides pre-synthesized EDTA-Zn complexes that release Zn ²⁺ to repair zinc anode defects under interfacial electric field, adsorbs onto zinc anode surface to block oxygen and water molecules, inhibits corrosion and hydrogen evolution reactions, promotes uniform Zn ²⁺ deposition, suppresses zinc dendrite formation, and modulates the hydrogen bonding network within the electrolyte. Zn(II)-EDTA disodium tetrahydrate acts as an electrolyte additive to enhance reversibility and stability of zinc anodes in aqueous zinc-ion batteries .

HY-W040203

Decyl β-D-maltopyranoside	Biochemical Assay Reagents	Others
Decyl β-D-maltopyranoside is an epithelial permeability enhancer. Decyl β-D-maltopyranoside regulates the paracellular transport pathway and increases the permeability of molecules and proteins transported via the paracellular route. Decyl β-D-maltopyranoside enhances the transepithelial paracellular permeability of EPO across cell monolayers .

HY-122203

PCS1055 dihydrochloride 2 Publications Verification	mAChR Cholinesterase (ChE)	Neurological Disease
PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC₅₀ of 18.1 nM and a K_d of 5.72 nM. PCS1055 dihydrochloride inhibits radioligand [ ³H]-NMS binding to the M4 receptor with a K_i of 6.5 nM. PCS1055 dihydrochloride exhibits >100-fold selectivity over M1-, M3-, and M5-receptors and 30-fold selectivity at the M2 receptor. PCS1055 dihydrochloride is also a potent AChE inhibitor with IC₅₀ s of 22 nM and 120 nM for electric eel and human AChE, respectively .

HY-110389

Pitofenone hydrochloride	Cholinesterase (ChE)	Neurological Disease
Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with K_is of 36 and 45 μM, respectively .

HY-N7436

Methyl propyl disulfide	Glutathione S-transferase	Cancer
Methyl propyl disulfide is an orally administrable volatile sulfide present in onions. Methyl propyl disulfide reduces the activity of spermine N'1-acetyltransferase (SAT), inhibits cell proliferation, and decreases the induction of placental glutathione S-transferase (GST-P)-positive hepatocyte foci in rat livers. Methyl propyl disulfide can be used in studies related to the mechanism of hepatocarcinogenesis .

HY-122203A

PCS1055 2 Publications Verification	mAChR Cholinesterase (ChE)	Neurological Disease
PCS1055 is a selective and competitive antagonist for muscarinic M4 receptor with an IC₅₀ of 18.1 nM and a K_d of 5.72 nM. PCS1055 inhibits radioligand [ ³H]-NMS binding to the M4 receptor with a K_i of 6.5 nM. PCS1055 is also an inhibitor for AChE with IC₅₀ of 22 nM and 120 nM for electric eel and human AChE, respectively .

HY-N10917

Xanthohumol I	Drug Derivative	Infection Cancer
Xanthohumol I is a derivative of Chalcone (HY-121054) that can be isolated from Humulus lupulus L. (hops). Xanthohumol I exhibits free radical scavenging activity .

HY-W075176

Transfluthrin	Insecticide	Infection
Transfluthrin is an insecticide with extremely low acute toxicity to vertebrates. Transfluthrin acts as a mosquito repellent, exerts mosquito control effects via electric heating fumigators, and is widely used in studies related to malaria, bancroftian filariasis and mosquito-borne infectious diseases. Transfluthrin may also induce adverse reactions such as pulmonary sensory irritation, sensitization, genotoxicity and respiratory depression, and can increase the concentrations and activities of CYP2E1 and CYP3A2 in rat brains. Transfluthrin can be removed from wastewater through biodegradation and activated sludge adsorption, and can be degraded by microorganisms such as Azovibrio and Tauera .

HY-W075176R

Transfluthrin (Standard)	Insecticide Reference Standards	Others
Transfluthrin (Standard) is the analytical standard of Transfluthrin (HY-W075176). This product is intended for research and analytical applications. Transfluthrin is an insecticide with extremely low acute toxicity to vertebrates. Transfluthrin acts as a mosquito repellent, exerts mosquito control effects via electric heating fumigators, and is widely used in studies related to malaria, bancroftian filariasis and mosquito-borne infectious diseases. Transfluthrin may also induce adverse reactions such as pulmonary sensory irritation, sensitization, genotoxicity and respiratory depression, and can increase the concentrations and activities of CYP2E1 and CYP3A2 in rat brains. Transfluthrin can be removed from wastewater through biodegradation and activated sludge adsorption, and can be degraded by microorganisms such as Azovibrio and Tauera .

HY-105853

Pitofenone	Cholinesterase (ChE)	Neurological Disease
Pitofenone, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with K_is of 36 and 45 μM, respectively .

HY-146663

AChE/BChE-IN-3	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-3 (BMC-1) is a dual AChE and BChE inhibitor with IC₅₀ values of 6.08 μM and 0.383 μM against electric eel AChE (elAChE) and equine serum BChE (eqBChE), respectively .

HY-146663A

AChE/BChE-IN-3 hydrochloride	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-3 (BMC-1) hydrochloride is a dual AChE and BChE inhibitor with IC₅₀ values of 6.08 μM and 0.383 μM against electric eel AChE (elAChE) and equine serum BChE (eqBChE), respectively .

HY-105853S

Pitofenone-d4	Isotope-Labeled Compounds	Neurological Disease
Pitofenone-d₄ is deuterium labeled Pitofenone (HY-105853). Pitofenone, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with K_is of 36 and 45 μM, respectively .

HY-N7263

Galanthamine N-Oxide	Cholinesterase (ChE)	Neurological Disease
Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC₅₀ of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes .

HY-146762

MAO-B-IN-7	Monoamine Oxidase Cholinesterase (ChE) Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
MAO-B-IN-7 is a potent and blood-brain barrier permeable MAO-B and AChE inhibitor with IC₅₀s of 41 nM, 87 nM and 0.3 μM for human AChE, electric eel AChE and MAO-B, respectively. MAO-B-IN-7 can effectively alleviate oxidative stress and neuroinflammatory damage .

HY-146035

AChE-IN-14	Cholinesterase (ChE) Histamine Receptor	Neurological Disease
AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC₅₀s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H₃ receptor (H₃R; K_i= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease .

HY-108327

PF-05020182	Potassium Channel	Neurological Disease
PF-05020182 is an orally active opener for Kv7 channel, that activates human Kv7.2/7.3, Kv7.4 and Kv7.3/7.5 with EC₅₀ of 334, 625 and 588 nM, respectively. PF-05020182 exhibits anticonvulsant activity in rats corneal electric shock-induced tonic seizure (MES) models. PF-05020182 is blood-brain barrier (BBB) penetrable .

HY-11090A

DPC423	Factor Xa Kallikrein Thrombin Ser/Thr Protease	Cardiovascular Disease
DPC423 is a selective and orally active factor Xa inhibitor with a K_is of 0.15 (human) and 0.3 (rabbit) nM. DPC423 exhibits K_is of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 can be used for the study of anticoagulation of arterial thrombosis .

HY-11090

DPC423 free base	Factor Xa Kallikrein Thrombin Ser/Thr Protease	Cardiovascular Disease
DPC423 free base is a selective and orally active factor Xa inhibitor with a K_is of 0.15 (human) and 0.3 (rabbit) nM. DPC423 free base exhibits K_is of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 free base blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 free base can be used for the study of anticoagulation of arterial thrombosis .

HY-144790

AChE-IN-12	Amyloid-β Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC₅₀s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC₅₀ = 8.8 μM). AChE-IN-12 has remarkable inhibition of self- and Cu ²⁺-induced Aβ_1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease .

HY-122400

Tetrantoin Spirodon	Drug Derivative	Neurological Disease
Tetrantoin (Spirodon) is a spirocyclic hydantoin and anticonvulsant with an approximate ED₅₀ of 54 mg/kg.Tetrantoin inhibits and prevents convulsions induced by maximum electric shock test.Tetrantoin can be used for the research of epilepsy .

HY-N19855

Merulinic acid Geranicardic acid	Cholinesterase (ChE)	Neurological Disease
Merulinic acid (Geranicardic acid) is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ >94 μM against electric eel-derived AChE. Merulinic acid can be used for the research of alzheimer’s disease .

HY-183303

AChE-IN-116	Cholinesterase (ChE) Reactive Oxygen Species (ROS)	Neurological Disease
AChE-IN-116 is a selective acetylcholinesterase (AChE) inhibitor with an electric eel AChE IC₅₀ of 1.60 μM and K_i of 1.72 μM. AChE-IN-116 exhibits weak ability to scavenge DPPH radical. AChE-IN-116 can be used for the research of Alzheimer's disease .

HY-181861

AChE/MAO-B-IN-9	Cholinesterase (ChE) Monoamine Oxidase Amyloid-β Tau Protein	Neurological Disease
AChE/MAO-B-IN-9 (Compound E12) is an orally active, selective, reversible, non-competitive AChE and MAO-B inhibitor, with an IC₅₀ of 0.156 μM against electric eel AChE. AChE/MAO-B-IN-9 inhibits Aβ40/42 fibril formation, promotes Aβ fibril depolymerization, and inhibits Tau protein fibril formation. AChE/MAO-B-IN-9 exerts antioxidant and neuroprotective effects, and improves scopolamine (HY-N0296)-induced memory impairment in mice. AChE/MAO-B-IN-9 can be used for the research of Alzheimer's disease .

HY-182254

AChE/BChE-IN-35	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-35, Tacrine (HY-111338) derivative, is a brain-penetrant dual AChE/BChE inhibitor with an Electric Eel AChE IC₅₀ of 123.66 nM, human AChE IC₅₀ of 122.34 nM, and equine BChE IC₅₀ of 488.00 nM. AChE/BChE-IN-35 undergoes LAT1-mediated active transport across cell membranes. AChE/BChE-IN-35 exhibits enhanced brain exposure with slower brain tissue elimination. AChE/BChE-IN-35 can be used for the research of alzheimer's disease .

HY-183760

AChE/BChE-IN-37	Cholinesterase (ChE) HSP GSK-3 Amyloid-β	Neurological Disease Inflammation/Immunology
AChE/BChE-IN-37 is a blood-brain barrier-permeable AChE/BChE inhibitor, with an IC₅₀ of 73.65 μM against electric eel-derived AChE and an IC₅₀ of 82.93 μM against horse-derived BChE. AChE/BChE-IN-37 exhibits chelating activity towards Cu ²⁺, Ca ²⁺, Mg ²⁺, Fe ²⁺ and Zn ²⁺. AChE/BChE-IN-37 interacts with HSP90AA1 and GSK-3β. AChE/BChE-IN-37 inhibits the self-induced aggregation of Aβ_1-42. AChE/BChE-IN-37 suppresses LPS-induced NO production in cells. AChE/BChE-IN-37 can be used in research related to Alzheimer's disease and inflammatory diseases .

HY-181161

AChE-IN-107	Cholinesterase (ChE)	Neurological Disease
AChE-IN-107 is a selective acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 0.22 μM and a K_i of 0.207 μM. AChE-IN-107 shows no inhibitory effect on equine serum BChE at 10 μM. AChE-IN-107 exhibits mixed-type inhibition of electric eel acetylcholinesterase, binding to both free enzyme and enzyme-substrate complex. AChE-IN-107 acts as a cytotoxin, reduces cell viability in hepatocellular carcinoma HepG2 cells.AChE-IN-107 can be used for the research of alzheimer's disease .

HY-N13756

Deoxymikanolide	Bacterial Reactive Oxygen Species (ROS) SOD	Infection Neurological Disease
Deoxymikanolide is an orally active antibacterial agent that inhibits catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activities. Deoxymikanolide increases glycan metabolism, phosphorus metabolism, electric conductivity, intrabacterial reactive oxygen species (ROS) levels, and malondialdehyde (MDA) levels, causes cell shrinkage, cytoplasmic damage, and cell disruption in Ralstonia solanacearum. Deoxymikanolide inhibits Acetic acid-induced writhing in mice. Deoxymikanolide can be used for the research of bacterial wilt .

HY-185346

AChE-IN-113	Cholinesterase (ChE)	Neurological Disease
AChE-IN-113 is a selective acetylcholinesterase inhibitor with a K_i value of 8.3 μM against electric eel acetylcholinesterase. AChE-IN-113 can be used for the research of Alzheimer's disease .

HY-172219

CUR-IPA	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
CUR-IPA is a cholinesterase inhibitor, with IC₅₀ of 5.99, 59.30, and 60.66 μM for eAChE (electric eel), hAChE (human), and hBChE (human), respectively. CUR-IPA can scavenge free radicals and has antioxidant activity. CUR-IPA can be used in the research of cognitive dysfunction .

HY-182599

RCC-36 hydrochloride	Calcium Channel mAChR	Neurological Disease
RCC-36 hydrochloride is an L-type calcium channel inhibitor and competitive muscarinic receptor antagonist. RCC-36 hydrochloride inhibits L-type calcium currents in voltage- and concentration-dependent fashion with no effect on cardiac K ⁺ currents. RCC-36 hydrochloride suppresses maximum acetylcholine-induced contractile responses, inhibits detrusor muscle contractions induced by potassium chloride, calcium chloride, and electric field stimulation, including atropine-resistant contractions. RCC-36 hydrochloride can be used for the research of urinary frequency, urinary incontinence, and bladder overactivity .

HY-N16715

Monardic acid A	Cholinesterase (ChE)	Neurological Disease
Monardic acid A is a selective inhibitor of AChE, with an IC₅₀ of 53.1 μM against AChE from electric eel. Monardic acid A shows weak inhibitory activity against human erythrocyte AChE (IC₅₀ >100 μM) and has no significant inhibitory effect on BChE. Monardic acid A reduces acetylcholine breakdown by inhibiting AChE activity, and also exhibits inhibitory activity against histamine release and hyaluronidase, thus exerting anti-inflammatory and neurotransmitter regulatory effects. Monardic acid A can be isolated from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus), and is mainly used in the development of anti-inflammatory drugs and drugs related to neurodegenerative diseases .

HY-185347

AChE-IN-114	Cholinesterase (ChE)	Neurological Disease
AChE-IN-114 is a selective AChE inhibitor and shows weak inhibitory activity for BChE. AChE-IN-114 can be used for the research of alzheimer’s disease .

HY-N17394

Melineurine	Cholinesterase (ChE)	Neurological Disease
Melineurine is a reversible mixed-type acetylcholinesterase inhibitor, with an IC₅₀ of 95.3 μM against AChE and an IC₅₀ of 28.0 μM against BChE. Melineurine is applicable to the research of Alzheimer's disease .

HY-181851

AChE-IN-109	Cholinesterase (ChE)	Neurological Disease
AChE-IN-109 is a potent mixed-type cholinesterase inhibitor with significantly stronger inhibitory activity against AChE than BChE. AChE-IN-109 has IC₅₀ values of 0.55 μM and 12.45 μM against AChE and BChE, respectively. AChE-IN-109 inhibits cholinesterases through a mixed-type mechanism, binds to both the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. AChE-IN-109 can be used for the study of Alzheimer’s disease (AD) .

HY-181811

PJ17	Cholinesterase (ChE) GSK-3	Neurological Disease
PJ17 is a potent dual-target inhibitor of AChE and GSK-3β, with IC₅₀ values of 8.84 μM and 4.19 μM, respectively. PJ17 shows no significant neurotoxic effect in primary cerebellar granule neuron cultures. PJ17 serves as a template for the design of multitarget drugs. PJ17 can be used for the research of Alzheimer's disease .

HY-114811

Leptophos oxon	Insecticide GABA Receptor Chloride Channel	Infection Neurological Disease
Leptophos oxon, a metabolite of leptophos, is a GABA_A receptor chloride channel inhibitor with an IC₅₀ values of 89.6 μM. Leptophos oxon inhibits GABA-induced chloride influx, binds to GABA_A receptor-associated TBPS sites, and inhibits TBPS binding to voltage-dependent chloride channels. Leptophos oxon is a insecticide. Leptophos oxon can be used for the research of neurological disease .

Cat. No.	Product Name	Type

HY-W127776

Zn(Ⅱ)-EDTA disodium tetrahydrate Ethylenediaminetetraacetic acid zinc disodium tetrahydrate	Biochemical Assay Reagents
Zn(II)-EDTA (Ethylenediaminetetraacetic acid zinc) disodium tetrahydrate is a coordinating agent. Zn(II)-EDTA disodium tetrahydrate coordinates with Zn ²⁺ to modify its solvated structure, provides pre-synthesized EDTA-Zn complexes that release Zn ²⁺ to repair zinc anode defects under interfacial electric field, adsorbs onto zinc anode surface to block oxygen and water molecules, inhibits corrosion and hydrogen evolution reactions, promotes uniform Zn ²⁺ deposition, suppresses zinc dendrite formation, and modulates the hydrogen bonding network within the electrolyte. Zn(II)-EDTA disodium tetrahydrate acts as an electrolyte additive to enhance reversibility and stability of zinc anodes in aqueous zinc-ion batteries .

Zn(Ⅱ)-EDTA disodium tetrahydrate

Ethylenediaminetetraacetic acid zinc disodium tetrahydrate

Biochemical Assay Reagents

Zn(II)-EDTA (Ethylenediaminetetraacetic acid zinc) disodium tetrahydrate is a coordinating agent. Zn(II)-EDTA disodium tetrahydrate coordinates with Zn ²⁺ to modify its solvated structure, provides pre-synthesized EDTA-Zn complexes that release Zn ²⁺ to repair zinc anode defects under interfacial electric field, adsorbs onto zinc anode surface to block oxygen and water molecules, inhibits corrosion and hydrogen evolution reactions, promotes uniform Zn ²⁺ deposition, suppresses zinc dendrite formation, and modulates the hydrogen bonding network within the electrolyte. Zn(II)-EDTA disodium tetrahydrate acts as an electrolyte additive to enhance reversibility and stability of zinc anodes in aqueous zinc-ion batteries .

HY-W040203

Decyl β-D-maltopyranoside	Biochemical Assay Reagents
Decyl β-D-maltopyranoside is an epithelial permeability enhancer. Decyl β-D-maltopyranoside regulates the paracellular transport pathway and increases the permeability of molecules and proteins transported via the paracellular route. Decyl β-D-maltopyranoside enhances the transepithelial paracellular permeability of EPO across cell monolayers .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7436

Methyl propyl disulfide	Structural Classification Natural Products Liliaceae Classification of Application Fields Allium cepa L. Plants Disease Research Fields Source Classification Cancer	Glutathione S-transferase
Methyl propyl disulfide is an orally administrable volatile sulfide present in onions. Methyl propyl disulfide reduces the activity of spermine N'1-acetyltransferase (SAT), inhibits cell proliferation, and decreases the induction of placental glutathione S-transferase (GST-P)-positive hepatocyte foci in rat livers. Methyl propyl disulfide can be used in studies related to the mechanism of hepatocarcinogenesis .

HY-N10917

Xanthohumol I	Structural Classification Humulus lupulus L. Phenols Polyphenols Plants Moraceae Source Classification	Drug Derivative
Xanthohumol I is a derivative of Chalcone (HY-121054) that can be isolated from Humulus lupulus L. (hops). Xanthohumol I exhibits free radical scavenging activity .

HY-N7263

Galanthamine N-Oxide	Alkaloids other families Plants Source Classification	Cholinesterase (ChE)
Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC₅₀ of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes .

HY-N19855

Merulinic acid Geranicardic acid	Structural Classification Microorganisms Antibiotics Source Classification	Cholinesterase (ChE)
Merulinic acid (Geranicardic acid) is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ >94 μM against electric eel-derived AChE. Merulinic acid can be used for the research of alzheimer’s disease .

HY-N13756

Deoxymikanolide	Structural Classification Terpenoids Sesquiterpenes Asteraceae Mikania micrantha Kunth Plants Source Classification	Bacterial Reactive Oxygen Species (ROS) SOD
Deoxymikanolide is an orally active antibacterial agent that inhibits catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activities. Deoxymikanolide increases glycan metabolism, phosphorus metabolism, electric conductivity, intrabacterial reactive oxygen species (ROS) levels, and malondialdehyde (MDA) levels, causes cell shrinkage, cytoplasmic damage, and cell disruption in Ralstonia solanacearum. Deoxymikanolide inhibits Acetic acid-induced writhing in mice. Deoxymikanolide can be used for the research of bacterial wilt .

HY-N16715

Monardic acid A	Structural Classification Lignans Phenylpropanoids Plants Pulmonaria officinalis L. Boraginaceae Source Classification	Cholinesterase (ChE)
Monardic acid A is a selective inhibitor of AChE, with an IC₅₀ of 53.1 μM against AChE from electric eel. Monardic acid A shows weak inhibitory activity against human erythrocyte AChE (IC₅₀ >100 μM) and has no significant inhibitory effect on BChE. Monardic acid A reduces acetylcholine breakdown by inhibiting AChE activity, and also exhibits inhibitory activity against histamine release and hyaluronidase, thus exerting anti-inflammatory and neurotransmitter regulatory effects. Monardic acid A can be isolated from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus), and is mainly used in the development of anti-inflammatory drugs and drugs related to neurodegenerative diseases .

HY-N17394

Melineurine	Structural Classification Alkaloids Rutaceae Quinoline Alkaloids Melicope pteleifolia (Champ. ex Benth.) Hartley Plants Source Classification	Cholinesterase (ChE)
Melineurine is a reversible mixed-type acetylcholinesterase inhibitor, with an IC₅₀ of 95.3 μM against AChE and an IC₅₀ of 28.0 μM against BChE. Melineurine is applicable to the research of Alzheimer's disease .

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HY-P703476

	CALM3 Protein, Tetronarce californica Calmodulin; Tetronarce californica; Pacific electric ray; CaM	Others	E. coli
	CALM3 Protein, Tetronarce californica is the recombinant CALM3, expressed by E. coli , with tag Free labeled tag.

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HY-105853S

Pitofenone-d4
Pitofenone-d₄ is deuterium labeled Pitofenone (HY-105853). Pitofenone, a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with K_is of 36 and 45 μM, respectively .

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