1354712-92-7
Chemical Structure
PF-05020182
- CAS No.: 1354712-92-7
- Formula:C18H30N4O4
- Molecular Weight:366.46
IUPAC Name: N-(4,6-dimethoxy-2-(4-methoxypiperidin-1-yl)pyrimidin-5-yl)-3,3-dimethylbutanamide
InChIKey: XHJMCIALHJMEBB-UHFFFAOYSA-N
SMILES: O=C(CC(C)(C)C)NC1=C(OC)N=C(N2CCC(CC2)OC)N=C1OC
Biological Activity: PF-05020182 is an orally active opener for Kv7 channel, that activates human Kv7.2/7.3, Kv7.4 and Kv7.3/7.5 with EC50 of 334, 625 and 588 nM, respectively. PF-05020182 exhibits anticonvulsant activity in rats corneal electric shock-induced tonic seizure (MES) models. PF-05020182 is blood-brain barrier (BBB) penetrable[1].
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PF-05020182 | PF-05020182 is an orally active opener for Kv7 channel, that activates human Kv7.2/7.3, Kv7.4 and Kv7.3/7.5 with EC50 of 334, 625 and 588 nM, respectively. PF-05020182 exhibits anticonvulsant activity in rats corneal electric shock-induced tonic seizure (MES) models. PF-05020182 is blood-brain barrier (BBB) penetrable. | |||||||||||||||||||||
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Keywords
