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  4. Transfluthrin

Transfluthrin is an insecticide with extremely low acute toxicity to vertebrates. It acts as a mosquito repellent, exerts mosquito control effects via electric heating fumigators, and is widely used in studies related to malaria, bancroftian filariasis and mosquito-borne infectious diseases. Transfluthrin may also induce adverse reactions such as pulmonary sensory irritation, sensitization, genotoxicity and respiratory depression, and can increase the concentrations and activities of CYP2E1 and CYP3A2 in rat brains. Transfluthrin can be removed from wastewater through biodegradation and activated sludge adsorption, and can be degraded by microorganisms such as *Azovibrio* and *Tauera*.

For research use only. We do not sell to patients.

Transfluthrin

Transfluthrin Chemical Structure

CAS No. : 118712-89-3

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Transfluthrin Related Antibodies

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Description

Transfluthrin is an insecticide with extremely low acute toxicity to vertebrates. It acts as a mosquito repellent, exerts mosquito control effects via electric heating fumigators, and is widely used in studies related to malaria, bancroftian filariasis and mosquito-borne infectious diseases. Transfluthrin may also induce adverse reactions such as pulmonary sensory irritation, sensitization, genotoxicity and respiratory depression, and can increase the concentrations and activities of CYP2E1 and CYP3A2 in rat brains. Transfluthrin can be removed from wastewater through biodegradation and activated sludge adsorption, and can be degraded by microorganisms such as *Azovibrio* and *Tauera*[1][2][3].

In Vitro

Transfluthrin (0.015-5 mg per plate; 60 min/20 min pre-incubation, 48-72 h plate incubation) is non-genotoxic in bacterial reverse mutation assays for reference transfluthrin (TFL-R), while two generic transfluthrin samples (TFL-GVI, TFL-GVIII) induce dose-dependent base-pair substitutions in Salmonella typhimurium TA100 without metabolic activation[1].
Transfluthrin is genotoxic to human nasal mucosal epithelial cells of the inferior and middle nasal conchae[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Transfluthrin Related Antibodies
In Vivo

Transfluthrin (10×106 normal usage rate; inhalation; repeated; 2 weeks) causes no measurable toxic effects in rats, classifying the products as hazard class 4[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: White outbred male (220-250 g)[3]
Dosage: 10x normal usage rate
Administration: Inhalation; repeated; 2 weeks
Result: Detected no changes in nervous system, respiratory system, or liver function parameters.
Classified products as hazard class 4.
Clinical Trial
Molecular Weight

371.15

Formula

C15H12Cl2F4O2
CAS No.
SMILES

O=C(OCC1=C(C(F)=CC(F)=C1F)F)[C@H]2C(C)([C@@H]2/C=C(Cl)\Cl)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Transfluthrin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Transfluthrin118712-89-3Insecticidecerebellumactivated sludgeAzoarcusrat brainmosquitobancroftian filariasishuman nasal mucosal epithelial cellsThaueraSalmonella typhimurium TA100malariaInhibitorinhibitorinhibit

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