2390042-05-2
Chemical Structure
AChE-IN-14
- CAS. Nr.: 2390042-05-2
- Formula:C28H35NO3
- Molecular Weight:433.58
IUPAC Name: 2-(4-((6-(azepan-1-yl)hexyl)oxy)phenyl)-6-methyl-4H-chromen-4-one
InChIKey: UKIGXRPAJQOYHR-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(OCCCCCCN3CCCCCC3)C=C2)OC4=CC=C(C)C=C14
Biological Activity: AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC50s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease[1].
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AChE-IN-14 | AChE-IN-14 (compound 5) is a potent cholinesterase inhibitor with IC50s of 0.46 , 0.48, and 0.44 μM for electric eel acetylcholinesterase (eeAChE), human recombinant acetylcholinesterase (hAChE), and equine serum butyrylcholinesterase (eqBuChE), respectively. AChE-IN-14 exhibits high affinity toward human H3 receptor (H3R; Ki= 159.8 nM). AChE-IN-14 can be used for the research of Alzheimer’s disease. | |||||||||||||||||||||
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