17 Results for "

fibroblast activation protein alpha

" in MedChemExpress (MCE) Product Catalog:
Products (17)

17 Results for "fibroblast activation protein alpha" in MCE Product Catalog:

2
2 Cited Publications
Art. -Nr.: HY-P72659A
Reinheit:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha
Species:  
Source:  
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Art. -Nr.: HY-P99902
CAS. Nr.: 1776942-10-9
Synonyms: FAP-IL2v; RO6874281; RG7461

Target:  

Interleukin Related

Forschungsgebiete:  

Cancer

Simlukafusp alfa (FAP-IL2v) is an immunocytokine comprising an antibody against fibroblast activation protein α (FAPα) and an IL-2 variant that only binds IL-2Rβγ. Isotype: human IgG1 .
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Art. -Nr.: HY-159069
CAS. Nr.: 9010-72-4
Reinheit:  95.02%
Zymosan (ZM), 95% is a yeast cell wall-derived carbohydrate-rich preparation and immunomodulator. Zymosan (ZM), 95% binds to and activates TLR-2, TLR-4, and Dectin-1 receptor to trigger downstream signaling pathways. Zymosan (ZM), 95% upregulates TLR-2, TLR-4, and TNF-α mRNA expression, increases serum TNF-α levels, and stimulates splenocyte number and viability in mice. Zymosan (ZM), 95% attenuates melanoma growth progression, modulates macrophage marker gene expression, and mediates phagocytosis, ROS generation, and cytokine production. Zymosan (ZM), 95% reduces Connexin 43 protein and mRNA levels, inhibits gap junctional intercellular communication, and induces proinflammatory factor production in human corneal cells. Zymosan (ZM), 95% induces peritoneal inflammation in mice, functions as a drug carrier, and supports fibroblast cell attachment in hydrogel formulations. Zymosan (ZM), 95% can be used for the research of melanoma, tumors, fungal keratitis, ocular surface inflammatory disorders, and peritoneal inflammation .
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Art. -Nr.: HY-161074
CAS. Nr.: 2715113-34-9
Target:  

FAP

Forschungsgebiete:  

Cancer

PNT6555 is a fibroblast activation protein-α (FAP) inhibitor. PNT6555 has antitumor activity. PNT6555 can be used for imaging of FAP-positive tumors .
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Art. -Nr.: HY-P3136
CAS. Nr.: 25849-90-5
Synonyms: TRV120055
Forschungsgebiete:  

Cardiovascular Disease

TRV055 (TRV120055) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses [1]
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Art. -Nr.: HY-P3136A
Synonyms: TRV120055 hydrochloride
Target:  

Angiotensin Receptor

Forschungsgebiete:  

Cardiovascular Disease

TRV055 (TRV120055) hydrochloride is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV055 hydrochloride induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. RV055 hydrochloride activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. RV055 hydrochloride induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. RV055 hydrochloride can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses [1]
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Art. -Nr.: HY-177083
CAS. Nr.: 1841402-73-0
Synonyms: AVA-6000
Target:  

FAP

Forschungsgebiete:  

Cancer

Faridoxorubicin (AVA-6000) is a prodrug targeting fibroblast activation protein α (FAPα). Faridoxorubicin releases active doxorubicin through FAPα-mediated cleavage, enhancing intratumoral drug exposure and reducing cardiac toxicity. Faridoxorubicin is promising for research of solid tumors (e.g., colorectal cancer liver metastasis) .
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Art. -Nr.: HY-161262
CAS. Nr.: 2952588-12-2
Target:  

FAP

Forschungsgebiete:  

Cancer

SB03178 is a fibroblast activation protein-alpha (FAP) inhibitor. SB03178 can be conjugated with DOTA and can be used for cancer research .
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Art. -Nr.: HY-136727A
Target:  

Caspase Apoptosis

Forschungsgebiete:  

Cancer

Ac-LEVD-CHO (TFA) is an inhibitor of caspase-4. Ac-LEVD-CHO (TFA) can inhibit the expression and secretion of IL-1α expression as well as the activation of caspase-4 induced by the T. denticola periodontal pathogen surface protein Td92 in human gingival fibroblasts. Ac-LEVD-CHO (TFA) can also reduce the apoptosis due to the expression of the dominant negative adenoviral RNA-dependent protein kinase in A549 and PC3 cancer cell lines .
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Art. -Nr.: HY-P86341
Synonyms: Seprase; 170 kDa melanoma membrane-bound gelatinase; fibroblast activation protein alpha; Integral membrane serine protease;

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, ELISA

Reactivity:  

Human

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Art. -Nr.: HY-P81697
Synonyms: FAP; Seprase; 170 kDa melanoma membrane-bound gelatinase; fibroblast activation protein alpha; Integral membrane serine protease

Host:  

Mouse

Application:  

IHC-P, FC, ELISA

Reactivity:  

Human

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Art. -Nr.: HY-P86673A
Synonyms: Prolyl endopeptidase FAP; FAPA; fibroblast activation protein, alpha; 170 kDa melanoma membrane bound gelatinase; 170 kDa melanoma membrane-bound gelatinase; DPPIV; fibroblast activation protein alpha; Integral membrane serine protease; SEPR_HUMAN; 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; FAPalpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; Serine integral membrane protease; SIMP; Surface-expressed protease; Seprase; Antiplasmin-cleaving enzyme FAP, soluble form; APCE.

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human

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Art. -Nr.: HY-P86673
Synonyms: Prolyl endopeptidase FAP; FAPA; fibroblast activation protein, alpha; 170 kDa melanoma membrane bound gelatinase; 170 kDa melanoma membrane-bound gelatinase; DPPIV; fibroblast activation protein alpha; Integral membrane serine protease; SEPR_HUMAN; 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; FAPalpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; Serine integral membrane protease; SIMP; Surface-expressed protease; Seprase; Antiplasmin-cleaving enzyme FAP, soluble form; APCE.

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human

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Art. -Nr.: HY-P81345
Synonyms: FAP; Seprase; 170 kDa melanoma membrane-bound gelatinase; fibroblast activation protein alpha; Integral membrane serine protease

Host:  

Rabbit

Application:  

WB, IHC-P

Reactivity:  

Human

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Art. -Nr.: HY-P81345A
Synonyms: FAP; Seprase; 170 kDa melanoma membrane-bound gelatinase; fibroblast activation protein alpha; Integral membrane serine protease

Host:  

Rabbit

Application:  

WB, IHC-P

Reactivity:  

Human

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Art. -Nr.: HY-P77521
Reinheit:  ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha
Species:  
Source:  
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Art. -Nr.: HY-P75759
Reinheit:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Prolyl endopeptidase FAP; FAP; FAPA; DPPIV; SIMP; Fapalpha
Species:  
Source:  
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