1 Result for "

hIMB-1636

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "hIMB-1636" in MCE Product Catalog:

hIMB1636
hIMB1636
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Cat. No.: HY-P992367

Target:  

TROP2

Research Areas:  

Cancer

hIMB1636 is a humanized monoclonal antibody targeting Trop2. By binding to the conformational Trop2 epitope, hIMB1636 regulates related signaling pathways, triggers lysosomal endocytosis, and further induces apoptosis, cell cycle arrest, and antibody-dependent cellular cytotoxicity. hIMB1636 effectively inhibits tumor cell proliferation, migration and in vivo tumor growth, and also exerts bystander killing effect and mediates long-term retention. hIMB1636 can be conjugated with NOTA/DOTA for radiolabeling to enable immuno-PET imaging, or prepared as hIMB1636-LDP-AE to significantly inhibit the growth of breast cancer and lung cancer xenografts .
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