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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
hSGLT2
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "hSGLT2" in MCE Product Catalog:
47
47 Publications Verification
Synonyms: JNJ 28431754
Target:
Research Areas:
Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively .
47
47 Publications Verification
Cat. No.: HY-I0383
CAS No.: 928672-86-0
Synonyms: JNJ 28431754 hemihydrate
Target:
Research Areas:
Canagliflozin hemihydrate (JNJ28431754 hemihydrate) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively .
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17
5
Target:
Research Areas:
Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2 . Has the potential for the treatment of type 2 diabetes mellitus [2].
5
5 Cited Publications
Synonyms: PF-04971729 L-pyroglutamic acid
Target:
Research Areas:
Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2 . Has the potential for the treatment of type 2 diabetes mellitus [2].
Synonyms: GSK189075
Target:
Research Areas:
Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity sodium glucose cotransporter (SGLT2) inhibitor with Ki values of 1.95 μM, 2.14 μM, 43.1 μM, 8.57 μM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate is a proagent based on benzylpyrazole glucoside and is metabolized to its active form, Remogliflozin, in the body. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models .
Cat. No.: HY-15461R
CAS No.: 1210344-57-2
Synonyms: PF-04971729 (Standard)
Target:
Research Areas:
Ertugliflozin (Standard) is the analytical standard of Ertugliflozin. This product is intended for research and analytical applications. Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2 . Has the potential for the treatment of type 2 diabetes mellitus [2].
Cat. No.: HY-137145
CAS No.: 1408245-02-2
Galacto-dapagliflozin is a selective inhibitor for hSGLT2 with Ki of 25 nM .
Cat. No.: HY-14810
CAS No.: 647834-15-9
Synonyms: AVE-2268
Target:
Research Areas:
Atigliflozin (AVE-2268) is an orally active and selective SGLT-2 inhibitor, with IC50s of 10 nM and 8.2 μM for hSGLT-2 and hSGLT-1) respectively. Atigliflozin can lower the blood glucose and improve the impaired oral glucose tolerance. Atigliflozin can be used for research of type II diabetes mellitus .
Cat. No.: HY-114308
CAS No.: 1240305-17-2
Target:
Research Areas:
SGL5213 is a potent, oral active and low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor, with IC50 values of 29 nM and 20 nM for hSGLT1 and hSGLT2, respectively. SGL5213 has potential to treat type 2 diabetes treatment .
Cat. No.: HY-10451R
CAS No.: 842133-18-0
Synonyms: JNJ 28431754 (Standard)
Target:
Research Areas:
Canagliflozin (Standard) is the analytical standard of Canagliflozin. This product is intended for research and analytical applications. Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively .
Cat. No.: HY-112807
CAS No.: 2247314-23-2
Target:
Research Areas:
SGLT inhibitor-1 is a potent dual inhibitor of sodium glucose co-transporter proteins (SGLTs), inhibits hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively .
Cat. No.: HY-124664
CAS No.: 957772-01-9
Target:
Research Areas:
TP0438836 (compound 30b) is a SGLT1 inhibitor, with IC50 values of 28 nM and 7 nM for hSGLT1 and hSGLT2, respectively. TP0438836 can be used in diabetes research .
Cat. No.: HY-165438
CAS No.: 360775-96-8
Sergliflozin-A is a compound used to inhibit type 2 diabetes. It can inhibit glucose transporters in the kidney, competitively inhibit hSGLT1 and hSGLT2, and mutations at different sites have different effects on its inhibitory effect.
Cat. No.: HY-10451S2
Synonyms: JNJ 28431754-d6
Cat. No.: HY-15461S
CAS No.: 1298086-22-2
Synonyms: PF-04971729-d5
Cat. No.: HY-15461S1
Synonyms: PF-04971729-d9
Cat. No.: HY-166548S
CAS No.: 1233515-93-9
Synonyms: GSK189075-d7
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
