2. Membrane Transporter/Ion Channel
  3. SGLT
  4. Sergliflozin-A

Sergliflozin-A is a compound used to inhibit type 2 diabetes. It can inhibit glucose transporters in the kidney, competitively inhibit hSGLT1 and hSGLT2, and mutations at different sites have different effects on its inhibitory effect.

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Sergliflozin-A

Sergliflozin-A Chemical Structure

CAS No. : 360775-96-8

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Sergliflozin-A Related Antibodies

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SGLT1 SGLT2

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Description

Sergliflozin-A is a compound used to inhibit type 2 diabetes. It can inhibit glucose transporters in the kidney, competitively inhibit hSGLT1 and hSGLT2, and mutations at different sites have different effects on its inhibitory effect.

IC50 & Target

SGLT1

 

SGLT2

 

Cellular Effect
Cell Line Type Value Description References
CHO EC50
>8000 nM
Compound: 4a
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
[PMID: 18260618]
CHO EC50
>8 μM
Compound: 4a
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
[PMID: 18260618]
CHO EC50
9.2 nM
Compound: 4a
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
[PMID: 18260618]
CHO IC50
2300 nM
Compound: 3-active
Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
[PMID: 21873071]
CHO IC50
4.8 nM
Compound: 3-active
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins
[PMID: 21873071]
CHO IC50
6.25 nM
Compound: 6
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting
Inhibition of human recombinant SGLT2 expressed in CHO cells by liquid scintillation counting
[PMID: 20181486]
CHO-K1 IC50
2300 nM
Compound: 2-A
Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay
Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assay
[PMID: 22652255]
CHO-K1 IC50
4.8 nM
Compound: 2-A
Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay
Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay
[PMID: 22652255]
Molecular Weight

376.40

Formula

C20H24O7
CAS No.
SMILES

COC(C=C1)=CC=C1CC(C=CC=C2)=C2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Sergliflozin-A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sergliflozin-A360775-96-8SGLTSodium-dependent glucose cotransportersInhibitorinhibitorinhibit

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