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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
human DNA polymerase η
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "human DNA polymerase η" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-117664
CAS No.: 1633660-76-0
Target:
Research Areas:
PNR-7-02 is a dual Rev1 and human DNA polymerase η (hpol η) inhibitor, with an IC50 value of 8 μM against hpol η. PNR-7-02 binds to hpol η to disrupt the orientation of template DNA and block the catalytic function of hpol η. When used in combination with Cisplatin (HY-17394), PNR-7-02 induces DNA damage and replication stress in cells with intact hpol η function. PNR-7-02 can be used in mechanism studies related to chronic myeloid leukemia and ovarian cancer .
Cat. No.: HY-P703612
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: POLQ; DNA polymerase Eta; DNA polymerase Theta; PRO0327; POLH; polymerase (DNA Directed), Theta, Isoform CRA_c; polymerase (DNA Directed), Theta; Epididymis Secretory Sperm Binding Protein; polymerase (DNA) Theta
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
