1633660-76-0
Chemical Structure
PNR-7-02
- CAS No.: 1633660-76-0
- Formula:C24H16ClN3O2S
- Molecular Weight:445.92
IUPAC Name: 5-((5-chloro-1-(naphthalen-2-ylmethyl)-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
InChIKey: YNPDEEPROJUWCY-UHFFFAOYSA-N
SMILES: O=C1NC(NC(/C1=C\C2=CN(CC3=CC4=C(C=CC=C4)C=C3)C5=C2C=C(Cl)C=C5)=O)=S
Biological Activity: PNR-7-02 is a dual Rev1 and human DNA polymerase η (hpol η) inhibitor, with an IC50 value of 8 μM against hpol η. PNR-7-02 binds to hpol η to disrupt the orientation of template DNA and block the catalytic function of hpol η. When used in combination with Cisplatin (HY-17394), PNR-7-02 induces DNA damage and replication stress in cells with intact hpol η function. PNR-7-02 can be used in mechanism studies related to chronic myeloid leukemia and ovarian cancer[1][2].
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PNR-7-02 | 98.0% | PNR-7-02 is a dual Rev1 and human DNA polymerase η (hpol η) inhibitor, with an IC50 value of 8 μM against hpol η. PNR-7-02 binds to hpol η to disrupt the orientation of template DNA and block the catalytic function of hpol η. When used in combination with Cisplatin (HY-17394), PNR-7-02 induces DNA damage and replication stress in cells with intact hpol η function. PNR-7-02 can be used in mechanism studies related to chronic myeloid leukemia and ovarian cancer. | ||||||||||||||||||||
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- [1]. Ler AAL, et al. DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target. Front Oncol. 2022;11:822500. Published 2022 Feb 7. [Content Brief]
- [2]. Zafar MK, et al. A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells. Biochemistry. 2018;57(7):1262-1273. [Content Brief]
Keywords
