IAG-10
Based on 1 Customer Validation
IAG-10 is a selective DNA polymerase kappa (hpol κ) inhibitor with an IC50 value of 7.2 μM. IAG-10 exerts its function by disrupting the formation of the binary complex between the enzyme and DNA. IAG-10 enhances the antiproliferative and DNA-damaging activities of Temozolomide (HY-17364) in tumor cells with functional hpol κ expression. IAG-10 can be used in the research of cancers such as malignant brain tumors.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.77%
- CAS. Nr.: 2361305-69-1
- Formel: C21H17Cl2N5O
- Molecular Weight:426.30
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
DNA Polymerase |
In Vitro
IAG-10 (0.1-0.5 μM; 1 hour) potentiates the anti-proliferative effect of Temozolomide (HY-17364) in hpol κ-proficient HAP-1 cells but not in hpol κ-deficient cells, indicating target-dependent activity[1].
IAG-10 (0.5 μM; 1 hour) increases DNA damage in hpol κ-proficient HAP-1 cells alone and in combination with Temozolomide (HY-17364), with no effect in hpol κ-deficient cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:hpol κ-proficient (HAP-1), hpol κ-deficient (HAP-1 hpol κ KO) cells
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Concentration:0.1 μM, 0.5 μM
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Incubation Time:1 hour
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Result:Reduced colony formation by hpol κ-proficient cells at all TMZ concentrations tested when co-treated with 0.5 μM IAG-10 compared to TMZ alone.
Reduced colony formation to ~40% of untreated cells at 250 μM TMZ + 0.5 μM IAG-10, while TMZ alone allowed ~75% colony formation.
Caused no significant reduction in hpol κ-deficient cells.
Chemical Information
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CAS. Nr. 2361305-69-1
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Appearance Solid
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Molecular Weight 426.30
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Formel C21H17Cl2N5O
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Color White to off-white
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SMILES
O=C(N1C=C(C2=C1C=CC(Cl)=C2)/C=N/NC(N)=N)C3=CC=CC4=C3C=CC=C4.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (234.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3458 mL | 11.7288 mL | 23.4577 mL | 58.6441 mL |
| 5 mM | 0.4692 mL | 2.3458 mL | 4.6915 mL | 11.7288 mL | |
| 10 mM | 0.2346 mL | 1.1729 mL | 2.3458 mL | 5.8644 mL | |
| 15 mM | 0.1564 mL | 0.7819 mL | 1.5638 mL | 3.9096 mL | |
| 20 mM | 0.1173 mL | 0.5864 mL | 1.1729 mL | 2.9322 mL | |
| 25 mM | 0.0938 mL | 0.4692 mL | 0.9383 mL | 2.3458 mL | |
| 30 mM | 0.0782 mL | 0.3910 mL | 0.7819 mL | 1.9548 mL | |
| 40 mM | 0.0586 mL | 0.2932 mL | 0.5864 mL | 1.4661 mL | |
| 50 mM | 0.0469 mL | 0.2346 mL | 0.4692 mL | 1.1729 mL | |
| 60 mM | 0.0391 mL | 0.1955 mL | 0.3910 mL | 0.9774 mL | |
| 80 mM | 0.0293 mL | 0.1466 mL | 0.2932 mL | 0.7331 mL | |
| 100 mM | 0.0235 mL | 0.1173 mL | 0.2346 mL | 0.5864 mL |
IAG-10 Related Classifications
HY-180392 Related Classifications
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