2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. IAG-10

IAG-10 is a selective DNA polymerase kappa (hpol κ) inhibitor with an IC50 value of 7.2 μM. IAG-10 exerts its function by disrupting the formation of the binary complex between the enzyme and DNA. IAG-10 enhances the antiproliferative and DNA-damaging activities of Temozolomide (HY-17364) in tumor cells with functional hpol κ expression. IAG-10 can be used in the research of cancers such as malignant brain tumors.

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IAG-10

IAG-10 Chemical Structure

CAS No. : 2361305-69-1

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IAG-10 Related Antibodies

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Description

IAG-10 is a selective DNA polymerase kappa (hpol κ) inhibitor with an IC50 value of 7.2 μM. IAG-10 exerts its function by disrupting the formation of the binary complex between the enzyme and DNA. IAG-10 enhances the antiproliferative and DNA-damaging activities of Temozolomide (HY-17364) in tumor cells with functional hpol κ expression. IAG-10 can be used in the research of cancers such as malignant brain tumors[1].

IC50 & Target[1]

DNA Polymerase

 

In Vitro

IAG-10 (0.1-0.5 μM; 1 hour) potentiates the anti-proliferative effect of Temozolomide (HY-17364) in hpol κ-proficient HAP-1 cells but not in hpol κ-deficient cells, indicating target-dependent activity[1].
IAG-10 (0.5 μM; 1 hour) increases DNA damage in hpol κ-proficient HAP-1 cells alone and in combination with Temozolomide (HY-17364), with no effect in hpol κ-deficient cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IAG-10 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: hpol κ-proficient (HAP-1), hpol κ-deficient (HAP-1 hpol κ KO) cells
Concentration: 0.1 μM, 0.5 μM
Incubation Time: 1 hour
Result: Reduced colony formation by hpol κ-proficient cells at all TMZ concentrations tested when co-treated with 0.5 μM IAG-10 compared to TMZ alone.
Reduced colony formation to ~40% of untreated cells at 250 μM TMZ + 0.5 μM IAG-10, while TMZ alone allowed ~75% colony formation.
Caused no significant reduction in hpol κ-deficient cells.
Molecular Weight

426.30

Formula

C21H17Cl2N5O
CAS No.
SMILES

O=C(N1C=C(C2=C1C=CC(Cl)=C2)/C=N/NC(N)=N)C3=CC=CC4=C3C=CC=C4.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IAG-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IAG-102361305-69-1IAG10IAG 10DNA/RNA Synthesishpol κglioblastomaInhibitorinhibitorinhibit

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