2361305-69-1
Chemical Structure
IAG-10
- CAS No.: 2361305-69-1
- Formula:C21H17Cl2N5O
- Molecular Weight:426.30
IUPAC Name: (E)-2-((1-(1-naphthoyl)-5-chloro-1H-indol-3-yl)methylene)hydrazine-1-carboximidamide hydrochloride
InChIKey: SZNREUCGBWTSBL-ZRASAZTRSA-N
SMILES: O=C(N1C=C(C2=C1C=CC(Cl)=C2)/C=N/NC(N)=N)C3=CC=CC4=C3C=CC=C4.Cl
Biological Activity: IAG-10 is a selective DNA polymerase kappa (hpol κ) inhibitor with an IC50 value of 7.2 μM. IAG-10 exerts its function by disrupting the formation of the binary complex between the enzyme and DNA. IAG-10 enhances the antiproliferative and DNA-damaging activities of Temozolomide (HY-17364) in tumor cells with functional hpol κ expression. IAG-10 can be used in the research of cancers such as malignant brain tumors[1].
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IAG-10 | IAG-10 is a selective DNA polymerase kappa (hpol κ) inhibitor with an IC50 value of 7.2 μM. IAG-10 exerts its function by disrupting the formation of the binary complex between the enzyme and DNA. IAG-10 enhances the antiproliferative and DNA-damaging activities of Temozolomide (HY-17364) in tumor cells with functional hpol κ expression. IAG-10 can be used in the research of cancers such as malignant brain tumors. | |||||||||||||||||||||
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Keywords
