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Results for "

human EBP

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

2

Peptides

2

Natural
Products

11

Recombinant Proteins

9

Antibodies

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-164561
    TASIN-30
    1 Publications Verification

    Emopamil Binding Protein Ferroptosis Apoptosis Cancer
    TASIN-30 is a selective EBP inhibitor with an EC50 of 0.097 μM. TASIN-30 blocks the production of 7-dehydrocholesterol (7-DHC) and downstream cholesterol biosynthesis processes. TASIN-30 depletes downstream sterols, disrupts the integrity of lipid rafts in tumor cells, accelerates intracellular cholesterol consumption, and inhibits tumor cell proliferation. TASIN-30 induces ferroptosis and apoptosis by reducing 7-DHC levels and increasing phospholipid peroxidation. TASIN-30 achieves tumor suppression in nude mice with osteosarcoma. TASIN-30 can be used in cancer-related research such as colorectal cancer and osteosarcoma .
    TASIN-30
  • HY-162351

    Emopamil Binding Protein Metabolic Disease
    EBP-IN-1 is an orally active, blood-brain barrier-permeable inhibitor of emopamil binding protein (EBP). EBP-IN-1 has an IC50 of 8.2 μM against human ERG potassium channels (in CHO background). By inhibiting the sterol isomerase activity of EBP, EBP-IN-1 causes the accumulation of Zymostenol (HY-113345), and exhibits strong target binding in the brain after repeated administration in rodents. EBP-IN-1 also promotes oligodendrocyte formation in human cortical organoids and can be used in research related to multiple sclerosis .
    EBP-IN-1
  • HY-N6954
    Garcinone C
    2 Publications Verification

    ATM/ATR STAT CDK Hedgehog Inflammation/Immunology Cancer
    Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .
    Garcinone C
  • HY-115590

    Pim Caspase Apoptosis Necroptosis PARP NF-κB Cancer
    JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 (IC50 = 0.5 nM). JP11646 is freely reversible and ATP non-competitive. JP-11646 results in a decrease of PIM1, 2, and 3 mRNA. JP-11646 can effectively inhibit cell viability in small cell lung cancer (SCLC) and large cell neuroendocrine carcinomas of the lung (LCNEC). JP-11646 can cause a decrease in p-4EBP-1 protein, increasing the cleavage of caspases while decreasing caspase-3. JP-11646 induces apoptosis or necroptosis in cells. JP-11646 leads to reductions in MYC paralogs. JP-11646 can be used for the study of SCLC, LCNEC, human acute leukemia (AML), multiple myeloma (MM), and triple-negative breast cancer (TNBC) .
    JP-11646
  • HY-P10323

    Tumstatin (74-98), human

    Integrin FAK mTOR Apoptosis Cancer
    T7 Peptide is a protein synthesis inhibitor and anti-angiogenic agent, with a Kd of 10 nM for human transferrin receptor. T7 Peptide inhibits the phosphorylation of focal adhesion kinase, the activation of phosphatidylinositol 3-kinase and Akt, the kinase activity of mTOR, as well as the phosphorylation of 4E-BP1 in endothelial cells. T7 Peptide induces G0/G1 cell cycle arrest, apoptosis and protective autophagy in hepatocellular carcinoma cells, and suppresses tumor growth in mouse models. T7 Peptide is applicable to research related to cancer, glioblastoma, hepatocellular carcinoma and glioma .
    T7 Peptide
  • HY-P10323A

    Tumstatin (74-98), human TFA

    Integrin FAK mTOR Apoptosis Cancer
    T7 Peptide TFA is a protein synthesis inhibitor and anti-angiogenic agent, with a Kd of 10 nM for human transferrin receptor. T7 Peptide TFA inhibits the phosphorylation of focal adhesion kinase, the activation of phosphatidylinositol 3-kinase and Akt, the kinase activity of mTOR, as well as the phosphorylation of 4E-BP1 in endothelial cells. T7 Peptide TFA induces G0/G1 cell cycle arrest, apoptosis and protective autophagy in hepatocellular carcinoma cells, and suppresses tumor growth in mouse models. T7 Peptide TFA is applicable to research related to cancer, glioblastoma, hepatocellular carcinoma and glioma .
    T7 Peptide TFA
  • HY-130723A

    AMPK Cancer
    AMPK activator 2 (compound 7a) hydrochloride, a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 hydrochloride inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .
    AMPK activator 2 hydrochloride
  • HY-RS04130

    Small Interfering RNA (siRNA) Others

    EBP Human Pre-designed siRNA Set A contains three designed siRNAs for EBP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    EBP Human Pre-designed siRNA Set A
    EBP Human Pre-designed siRNA Set A
  • HY-RS04279

    Small Interfering RNA (siRNA) Others

    EIF4EBP3 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF4EBP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    EIF4EBP3 Human Pre-designed siRNA Set A
    EIF4EBP3 Human Pre-designed siRNA Set A
  • HY-RS04278

    Small Interfering RNA (siRNA) Others

    EIF4EBP2 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF4EBP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    EIF4EBP2 Human Pre-designed siRNA Set A
    EIF4EBP2 Human Pre-designed siRNA Set A
  • HY-RS04277

    Small Interfering RNA (siRNA) Others

    EIF4EBP1 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF4EBP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    EIF4EBP1 Human Pre-designed siRNA Set A
    EIF4EBP1 Human Pre-designed siRNA Set A
  • HY-130723

    AMPK Cancer
    AMPK activator 2 (compound 7a), a fluorine-containing proguanil derivative, up-regulates AMPK signal pathway and downregulates mTOR/4EBP1/p70S6K. AMPK activator 2 inhibits proliferation and migration of human cancer cell lines (UMUC3, T24, A549) .
    AMPK activator 2
  • HY-N6954R

    Reference Standards ATM/ATR STAT CDK Hedgehog Inflammation/Immunology Cancer
    Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .
    Garcinone C (Standard)

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