3034437-44-7
Chemical Structure
EBP-IN-1
- CAS No.: 3034437-44-7
- Formula:C24H33N3O3
- Molecular Weight:411.54
InChIKey: MWQKGNAORRKIIL-UHFFFAOYSA-N
SMILES: CCN1C(N(C2=CC=C(C3CC3)C=C2)C(C14CCN(CC5CCOCC5)CC4)=O)=O
Biological Activity: EBP-IN-1 is an orally active, blood-brain barrier-permeable inhibitor of emopamil binding protein (EBP). EBP-IN-1 has an IC50 of 8.2 μM against human ERG potassium channels (in CHO background). By inhibiting the sterol isomerase activity of EBP, EBP-IN-1 causes the accumulation of Zymostenol (HY-113345), and exhibits strong target binding in the brain after repeated administration in rodents. EBP-IN-1 also promotes oligodendrocyte formation in human cortical organoids and can be used in research related to multiple sclerosis[1].
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EBP-IN-1 | 99.77% | EBP-IN-1 is an orally active, blood-brain barrier-permeable inhibitor of emopamil binding protein (EBP). EBP-IN-1 has an IC50 of 8.2 μM against human ERG potassium channels (in CHO background). By inhibiting the sterol isomerase activity of EBP, EBP-IN-1 causes the accumulation of Zymostenol (HY-113345), and exhibits strong target binding in the brain after repeated administration in rodents. EBP-IN-1 also promotes oligodendrocyte formation in human cortical organoids and can be used in research related to multiple sclerosis. | ||||||||||||||||||||
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Keywords
