22 Results for "

human TNFR2

" in MedChemExpress (MCE) Product Catalog:
Products (22)

22 Results for "human TNFR2" in MCE Product Catalog:

13
13 Publications Verification
Cat. No.: HY-P1860
CAS No.: 144796-71-4
Research Areas:  

Inflammation/Immunology Cancer

TNF-α (31-45), human is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis .
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13
13 Publications Verification
Cat. No.: HY-P1860A
Research Areas:  

Inflammation/Immunology

TNF-α (31-45), human TFA is a potent NF-kB pathway activator. TNF-αis a proinflammatory cytokine that induces necrosis or apoptosis. TNF alpha stimulates NF-κB pathway via TNFR2 promotes cancer growth, invasion, and metastasis .
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1
1 Cited Publications
Cat. No.: HY-P72025
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1B; TNF-R2; Prev. TNFR2; Tumor Necrosis Factor Receptor Superfamily, Member 1B; TNFBR; Tumor Necrosis Factor Receptor Superfamily, Member 1b; P75; Tumor Necrosis Factor Binding Protein 2; TNF-R-II; Tumor Necrosis Factor Beta Receptor; TNF-R75; Solub
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Cat. No.: HY-P991400
GSK1995057 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK1995057 selectively binds to TNFR1, blocks the binding of TNF-α and LT-α, and does not interfere with TNFR2 signaling. GSK1995057 inhibits the activation of NF-κB, JNK and MAPK pathways, alleviates apoptosis (apoptosis) and inflammatory responses (inhibiting IL-1β, IL-6, IL-10, TNF-α), and prevents viability loss of human nucleus pulposus cells. GSK1995057 inhibits the expression of cytokines and neutrophil adhesion molecules in human pulmonary microvascular endothelial cell monolayers, and reduces inflammatory responses and lung injury symptoms in non-human primates. GSK1995057 forms complexes with HAVH autoantibodies, thereby activating TNFR1 and triggering the release of cytokines and IL-8 in human cells. GSK1995057 can be used in research related to intervertebral disc degeneration and acute lung injury .
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Cat. No.: HY-P991192

Target:  

TNF Receptor

Research Areas:  

Cancer

BI-1808 is a human IgG1 monoclonal antibody that targets TNFR2by blocking interaction of TNFR2 with ligand TNF-α, confers FcγR-dependent depletion of Treg and mediates expansion of intratumoral CD8 + T cells .
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Cat. No.: HY-P991402

Target:  

TNF Receptor NF-κB

Research Areas:  

Cancer

BI-1910 is an agonistic human IgG2 monoclonal antibody targeting TNFR2, which selectively binds to human TNFR2 without inhibiting TNF-α binding. As an endogenous agonist, BI-1910 activates TNFR2 and mediates the activation of the NF-κB signaling pathway. Its agonistic activity is independent of FcγR or cross-linking; it can directly costimulate T cells and NK cells, induce T cell proliferation, and activate tumor-specific CD8+ T cells. BI-1910 exhibits antitumor activity in vivo, and shows an additive antitumor effect when combined with anti-PD-1 (HY-P9902). It can be used in research related to advanced/metastatic non-small cell lung cancer and hepatocellular carcinoma. Recommended isotype control: Human IgG2 lambda, Isotype Control (HY-P991206) .
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Cat. No.: HY-124339
CAS No.: 2092913-64-7
JNJ525 is a TNFα inhibitor with IC50 values of 1.2 μM and 1.1 μM against TNFR1 and TNFR2, respectively. JNJ525 forms ordered aggregates and induces quaternary structural transition of TNFα, thereby blocking the protein-protein interaction between TNFα and its receptors. The inhibitory activity of JNJ525 is completely lost in the presence of 0.1% Triton X-100 .
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Cat. No.: HY-P991195
Synonyms: SIM1811-03

Target:  

TNF Receptor

Research Areas:  

Cancer

SIM-0235 is humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets and inhibits TNFR2, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) [1].
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Cat. No.: HY-P992399

Target:  

TNF Receptor NF-κB

Research Areas:  

Cancer

LBL-019 is a humanized IgG1 monoclonal antibody targeting TNFR2. LBL-019 costimulates TNFR2 and activates the NF-κB signaling pathway in an Fc crosslinking-dependent manner. LBL-019 can be used for the research of advanced malignant tumors, including hepatocellular carcinoma and melanoma. The recommended isotype control is human IgG1 kappa (HY-P99001) .
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Cat. No.: HY-P71914
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1B; TNF-R2; Prev. TNFR2; Tumor Necrosis Factor Receptor Superfamily, Member 1B; TNFBR; Tumor Necrosis Factor Receptor Superfamily, Member 1b; P75; Tumor Necrosis Factor Binding Protein 2; TNF-R-II; Tumor Necrosis Factor Beta Receptor; TNF-R75; Solub
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Cat. No.: HY-P76683
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1B; TNF-R2; Prev. TNFR2; Tumor Necrosis Factor Receptor Superfamily, Member 1B; TNFBR; Tumor Necrosis Factor Receptor Superfamily, Member 1b; P75; Tumor Necrosis Factor Binding Protein 2; TNF-R-II; Tumor Necrosis Factor Beta Receptor; TNF-R75; Solub
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Cat. No.: HY-P78526
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TNFRSF1B; TNF-R2; Prev. TNFR2; Tumor Necrosis Factor Receptor Superfamily, Member 1B; TNFBR; Tumor Necrosis Factor Receptor Superfamily, Member 1b; P75; Tumor Necrosis Factor Binding Protein 2; TNF-R-II; Tumor Necrosis Factor Beta Receptor; TNF-R75; Solub
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Cat. No.: HY-P701084
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1B; TNF-R2; Prev. TNFR2; Tumor Necrosis Factor Receptor Superfamily, Member 1B; TNFBR; Tumor Necrosis Factor Receptor Superfamily, Member 1b; P75; Tumor Necrosis Factor Binding Protein 2; TNF-R-II; Tumor Necrosis Factor Beta Receptor; TNF-R75; Solub
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Cat. No.: HY-P70536
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1B; TNF-R2; Prev. TNFR2; Tumor Necrosis Factor Receptor Superfamily, Member 1B; TNFBR; Tumor Necrosis Factor Receptor Superfamily, Member 1b; P75; Tumor Necrosis Factor Binding Protein 2; TNF-R-II; Tumor Necrosis Factor Beta Receptor; TNF-R75; Solub
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Cat. No.: HY-P71126
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1B; TNF-R2; Prev. TNFR2; Tumor Necrosis Factor Receptor Superfamily, Member 1B; TNFBR; Tumor Necrosis Factor Receptor Superfamily, Member 1b; P75; Tumor Necrosis Factor Binding Protein 2; TNF-R-II; Tumor Necrosis Factor Beta Receptor; TNF-R75; Solub
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Cat. No.: HY-P78795
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1B; TNF-R2; Prev. TNFR2; Tumor Necrosis Factor Receptor Superfamily, Member 1B; TNFBR; Tumor Necrosis Factor Receptor Superfamily, Member 1b; P75; Tumor Necrosis Factor Binding Protein 2; TNF-R-II; Tumor Necrosis Factor Beta Receptor; TNF-R75; Solub
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Cat. No.: HY-P705102
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFRSF1B; TNF-R2; Prev. TNFR2; Tumor Necrosis Factor Receptor Superfamily, Member 1B; TNFBR; Tumor Necrosis Factor Receptor Superfamily, Member 1b; P75; Tumor Necrosis Factor Binding Protein 2; TNF-R-II; Tumor Necrosis Factor Beta Receptor; TNF-R75; Solub
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Cat. No.: HY-P85568
Synonyms: AIP 1; AIP1; API 2; API2; API2; Apoptosis inhibitor 2; Baculoviral IAP repeat containing 3; Baculoviral IAP repeat containing protein 3; Baculoviral IAP repeat-containing protein 3; BIRC 3; BIRC3; BIRC3; BIRC3_human; C IAP2; C-IAP2; CIAP 2; CIAP 2; CIAP2; HAIP 1; HAIP1; HAIP1; HIAP 1; HIAP-1; HIAP1; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; Inhibitor of apoptosis protein 1; MALT 2; MALT2; Mammalian IAP homolog C; MIHC; MIHC; RING finger protein 49; RNF49; TNFR2 TRAF signaling complex protein 1; TNFR2 TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 1.

Host:  

Mouse

Application:  

WB

Reactivity:  

Human, Monkey

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Cat. No.: HY-P70345
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LTBR; Tumor Necrosis Factor Receptor Type III; Prev. D12S370; TNFR3; TNFRSF3; Lymphotoxin Beta Receptor (TNFR Superfamily, Member 3); TNFCR; TNFR Superfamily, Member 3; TNF-R-III; Lymphotoxin-Beta Receptor; TNFR2-RP; Lymphotoxin B Receptor; TNFR-RP; LT-BE
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Cat. No.: HY-P72806
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LTBR; Tumor Necrosis Factor Receptor Type III; Prev. D12S370; TNFR3; TNFRSF3; Lymphotoxin Beta Receptor (TNFR Superfamily, Member 3); TNFCR; TNFR Superfamily, Member 3; TNF-R-III; Lymphotoxin-Beta Receptor; TNFR2-RP; Lymphotoxin B Receptor; TNFR-RP; LT-BE
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