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By Targets:	Adenosine Receptor (2) Adrenergic Receptor (16) Akt (1) Angiotensin-converting Enzyme (ACE) (3) Anion Exchangers (1) Antibiotic (1) Apoptosis (5) Bacterial (1) c-Met/HGFR (1) Calcium Channel (7) Carbonic Anhydrase (1) Caspase (1) Cathepsin (1) CCR (1) CGRP Receptor (1) DGK (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (2) Drug Derivative (2) Elastase (1) Endogenous Metabolite (3) Endothelin Receptor (1) ERK (1) Eukaryotic Initiation Factor (eIF) (2) Fungal (1) Glutathione Peroxidase (2) Hemoglobin (1) Isotope-Labeled Compounds (6) Lipoxygenase (1) Mitochondrial Metabolism (1) MMP (4) Myosin (3) Na+/H+ Exchanger (NHE) (1) NADPH Oxidase (1) Neprilysin (1) NF-κB (1) NO Synthase (2) p38 MAPK (1) Parasite (1) Phosphodiesterase (PDE) (2) PI3K (1) PKC (1) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (12) PPAR (1) Prostaglandin Receptor (3) Ras (1) Reference Standards (9) SOD (1) Sodium Channel (1) TGF-beta/Smad (1) Thrombin (1) Topoisomerase (1) TRP Channel (1) YAP (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (61) Endocrinology (7) Infection (1) Inflammation/Immunology (7) Metabolic Disease (8) Neurological Disease (23)

By Targets:

Adenosine Receptor (2)

Adrenergic Receptor (16)

Akt (1)

Angiotensin-converting Enzyme (ACE) (3)

Anion Exchangers (1)

Antibiotic (1)

Apoptosis (5)

Bacterial (1)

c-Met/HGFR (1)

Calcium Channel (7)

Carbonic Anhydrase (1)

Caspase (1)

Cathepsin (1)

CCR (1)

CGRP Receptor (1)

DGK (1)

DNA Alkylator/Crosslinker (1)

DNA/RNA Synthesis (2)

Drug Derivative (2)

Elastase (1)

Endogenous Metabolite (3)

Endothelin Receptor (1)

ERK (1)

Eukaryotic Initiation Factor (eIF) (2)

Fungal (1)

Glutathione Peroxidase (2)

Hemoglobin (1)

Isotope-Labeled Compounds (6)

Lipoxygenase (1)

Mitochondrial Metabolism (1)

MMP (4)

Myosin (3)

Na+/H+ Exchanger (NHE) (1)

NADPH Oxidase (1)

Neprilysin (1)

NF-κB (1)

NO Synthase (2)

p38 MAPK (1)

Parasite (1)

Phosphodiesterase (PDE) (2)

PI3K (1)

PKC (1)

Platelet-activating Factor Receptor (PAFR) (1)

Potassium Channel (12)

PPAR (1)

Prostaglandin Receptor (3)

Ras (1)

Reference Standards (9)

SOD (1)

Sodium Channel (1)

TGF-beta/Smad (1)

Thrombin (1)

Topoisomerase (1)

TRP Channel (1)

YAP (1)

By Research Areas:

Cancer (14)

Cardiovascular Disease (61)

Endocrinology (7)

Infection (1)

Inflammation/Immunology (7)

Metabolic Disease (8)

Neurological Disease (23)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Atenolol 20+ Cited Publications (RS)-Atenolol	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Endocrinology Cancer
Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

GCN2iB Maximum Cited Publications 60 Publications Verification	Eukaryotic Initiation Factor (eIF) Glutathione Peroxidase	Cardiovascular Disease Metabolic Disease Cancer
GCN2iB is an ATP-competitive, selective GCN2 inhibitor with an IC₅₀ of 2.4 nM. GCN2iB inhibits the activation of the GCN2 pathway and upregulates GPX4. GCN2iB enhances the anticancer effect of ASNase against acute lymphoblastic leukemia. GCN2iB increases left ventricular ejection fraction, while reducing fasting blood glucose and myocardial fibrosis. GCN2iB can be used in research related to acute lymphoblastic leukemia, acute myeloid leukemia and diabetic cardiomyopathy .

Indapamide 1 Publications Verification	Potassium Channel	Cardiovascular Disease
Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy .

Coenzyme Q9 1 Publications Verification Ubiquinone Q9; CoQ9; Ubiquinone 9	Apoptosis Endogenous Metabolite	Cardiovascular Disease
Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis .

Methoxyamine hydrochloride 1 Publications Verification O-Methylhydroxylamine hydrochloride	DNA/RNA Synthesis Apoptosis	Cancer
Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents .

DL-Norepinephrine-d6 hydrochloride	Adrenergic Receptor	Neurological Disease Metabolic Disease
DL-Norepinephrine-d₆ hydrochloride is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine hydrochloride after being labeled with tritium can be used as a tracer for the research on Parkinson's disease .

Aladorian ARM036; S44121	Calcium Channel	Cardiovascular Disease
Aladorian (ARM036; S44121) is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian improves cardiomyocyte Ca²⁺ homeostasis independent of dystrophin restoration. Aladorian attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy .

Ulacamten CK-4021586; CK-586	Myosin	Cardiovascular Disease
Ulacamten (CK-4021586; CK-586) is an orally active cardiac myosin inhibitor and an inhibitor of the double-headed cardiac heavy meromyosin (HMM)ATPase (excluding single-headed myosin subfragment-1), with an EC₅₀ of 2.9 μM. Ulacamten regulates cardiac myosin, reduces excessive myocardial contractility, and alleviates left ventricular outflow tract obstruction. Ulacamten increases the left ventricular short-axis systolic internal diameter, inhibits dobutamine-induced exacerbation of obstruction, and exerts only a mild reducing effect on left ventricular systolic function. Ulacamten also inhibits the fractional shortening of the short axis without altering calcium transients. Ulacamten shows good safety and tolerability in purpose-bred cats with naturally occurring obstructive hypertrophic cardiomyopathy .

HMR 1556 2 Publications Verification	Potassium Channel	Cardiovascular Disease
HMR 1556, a chromanol derivative, is a potent I_Ks blocker with IC₅₀s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively .

Topobexin	Topoisomerase	Cardiovascular Disease
Topobexin is a TOP2B-selective inhibitor with IC₅₀ values of 0.19 μM and 4.8 μM for TOP2B and TOP2A (DNA decatenation assay). Topobexin binds to non-homologous residues in the obex pocket and targets the ATPase domain of TOP2B. Topobexin prevents anthracycline-induced DNA double-strand break formation, apoptotic signaling mediated by caspase 3/7, 8 and 9, cardiomyocyte morphological changes, mitochondrial depolarization/loss, left ventricular systolic dysfunction, extracellular matrix remodeling, fibrotic alterations, and increases in plasma cardiac troponin T and BNP. Topobexin does not impair the antiproliferative effects of anthracyclines in cancer cells, exhibits no intrinsic cytotoxicity in cardiomyocytes, and is well tolerated in rabbits. Topobexin can be used in studies related to anthracycline-induced cardiotoxicity .

4-Hydroxypropranolol hydrochloride (±)-4-hydroxy Propranolol hydrochloride	Adrenergic Receptor	Cardiovascular Disease
4-Hydroxypropranolol hydrochloride is a non-cardiac selective β-adrenergic receptor antagonist and a metabolite produced after oral administration of Propranolol (HY-B0573B). 4-Hydroxypropranolol hydrochloride also acts as a membrane stabilizer and possesses intrinsic sympathomimetic inhibitory activity. 4-Hydroxypropranolol hydrochloride blocks β-adrenergic receptors to antagonize the effects of catecholamines, acts as a partial β-adrenergic receptor agonist, and induces membrane stabilization. 4-Hydroxypropranolol hydrochloride alters heart rate, left ventricular contractility, and atrioventricular conduction time. 4-Hydroxypropranolol hydrochloride can be used in research related to cardiovascular and cerebrovascular diseases .

Xipamide	Anion Exchangers Carbonic Anhydrase Endothelin Receptor	Cardiovascular Disease
Xipamide is an orally active carbonic anhydrase (CA) inhibitor and Na ⁺/Cl ^--potassium transporter inhibitor with diuretic and antihypertensive effects. Xipamide reduces NaCl reabsorption by inhibiting the Cl ^-/NaCO₃ ^- anion exchanger, and increases calcium reabsorption while promoting potassium and magnesium excretion. Xipamide is mainly cleared via the renal pathway and causes a temporary decrease in glomerular filtration rate under specific conditions. Xipamide does not affect Ca ²⁺ signaling induced by endothelin-1 and other factors, nor does it inhibit various ion cotransport or pump activities in red blood cells. Xipamide can be used in researches related to cardiovascular diseases, hypertension (especially with left ventricular hypertrophy), advanced renal failure, and liver cirrhosis with ascites .

DL-Norepinephrine hydrochloride 2 Publications Verification	Adrenergic Receptor	Neurological Disease
DL-Norepinephrine hydrochloride is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine hydrochloride after being labeled with tritium can be used as a tracer for the research on Parkinson's disease .

DL-Norepinephrine tartrate 2 Publications Verification	Adrenergic Receptor	Neurological Disease
DL-Norepinephrine tartrate is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine tartrate after being labeled with tritium can be used as a tracer for the research on Parkinson's disease .

Vemtoberant APD418	Adrenergic Receptor	Cardiovascular Disease
Vemtoberant is a β₃-adrenergic receptor inhibitor with a human K_i of 8.2 nM, and exhibits 400- to 600-fold selectivity over human β₁-AR and β₂-AR. Vemtoberant attenuates β₃-AR-mediated cardiac inhibition. Vemtoberant can be used for the research of systolic heart failure .

Xamoterol hemifumarate Corwin hemifumarate; ICI 118587 hemifumarate	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
Xamoterol (Corwin; ICI 118587) hemifumarate is an orally active and selective β₁-adrenoceptor partial agonist. Xamoterol hemifumarate acts as agonist at low sympathetic tone, antagonist at high sympathetic tone, with context-dependent cardiovascular effects including modulated heart rate, blood pressure, and cardiac output. Xamoterol hemifumarate can be used for the research of heart failure, postural hypotension, and ischemic heart disease .

(+)-EMD 57033	Phosphodiesterase (PDE)	Cardiovascular Disease
(+)-EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca ²⁺ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function .

N-Oleoyldopamine OLDA	TRP Channel Lipoxygenase	Cardiovascular Disease Neurological Disease Metabolic Disease
N-Oleoyldopamine (OLDA) is an orally active TRPV1 activator and 5-LOX inhibitor with blood-brain barrier permeability. N-Oleoyldopamine excites histaminergic neurons in the tuberomammillary nucleus via a dopamine receptor mechanism, a process independent of TRPV1 and cannabinoid receptors. On one hand, N-Oleoyldopamine promotes the release of insulin and glucose-dependent insulinotropic polypeptide through a GPR119-dependent pathway to improve glucose tolerance; on the other hand, N-Oleoyldopamine improves left ventricular function and reduces myocardial infarction size by triggering the release of substance P and calcitonin gene-related peptide. N-Oleoyldopamine is used in studies related to glycemic abnormalities and myocardial ischemia-reperfusion injury .

Hirudin (54-65)	Thrombin YAP Calcium Channel	Metabolic Disease
Hirudin (54-65) is a thrombin antagonist and YAP suppressor with anticoagulatory properties.Hirudin (54-65) blocks thrombin's anion binding site, acts on soluble and thrombus-bound thrombin.Hirudin (54-65) suppresses thrombin-induced profibrotic YAP activity, reduces YAP expression, nuclear translocation, and downstream effector signaling in vascular endothelial cells.Hirudin (54-65) ameliorates obstructive cholestasis, attenuates liver fibrosis symptoms, fibrosis-associated angiogenesis, and endothelial-to-mesenchymal transition.Hirudin (54-65) reduces liver inflammation and tissue hypoxia.Hirudin (54-65) promotes extracellular calcium influx through L-type calcium channels in canine coronary artery smooth muscle, mediates contraction.Hirudin (54-65) induces endothelium-independent contraction of canine coronary arterial segments; this response is not affected by indomethacin pretreatment.Hirudin (54-65) can be used for the research of liver obstructive cholestasis, liver fibrosis .

ONO 1301 ONO-AP 500-02	Prostaglandin Receptor	Cardiovascular Disease
ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig .

(Z)-ONO 1301 (Z)-ONO-AP 500-02	Prostaglandin Receptor	Cardiovascular Disease
(Z)-ONO 1301 is the isomer of ONO 1301 (HY-106961), and can be used as an experimental control. ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig .

PD-166793	MMP	Cardiovascular Disease
PD-166793 is a potent, selective, orally active and wide-broad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP-2, MMP-3 and MMP-13 (IC₅₀=4, 7, and 8 nM, respectively) and micromolar potency vs MMP-1, -7 and -9 (IC₅₀=6.0, 7.2, and 7.9 μM, respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure .

FC9402 2 Publications Verification	Mitochondrial Metabolism	Cardiovascular Disease
FC9402 is a potent and selective sulfide quinone oxidoreductase (SQOR) inhibitor extracted from patent WO 2020/146636 A1. FC9402 attenuates TAC-induced cardiomyocyte hypertrophy and left ventricle (LV) fibrosis. FC9402 can be used for cardiovascular regulation .

(S)-Veludacigib (S)-BAY 2965501	DGK ERK	Cancer
(S)-BAY 2965501 is the left-handed isomer of BAY 2965501 (HY-153343). BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer .

HGF-IN-1	c-Met/HGFR	Cancer
HGF-IN-1 ((the compound on the left in the second line of page 77) is a HGF inhibitor. HGF-IN-1 can be used in cancer research .

Atenolol (Standard) 20+ Cited Publications (RS)-Atenolol (Standard)	Reference Standards Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Atenolol (Standard) is the analytical standard of Atenolol. This product is intended for research and analytical applications. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

Delocamten	Myosin	Cardiovascular Disease
Delocamten is the inhibitor for cardiac myosin with an IC₅₀ of 1.1 μM. Delocamten can be used in researchs of hypertrophic cardiomyopathy, left ventricular hypertrophy and diastolic dysfunction .

Coenzyme Q9 (Standard) Ubiquinone Q9 (Standard); CoQ9 (Standard); Ubiquinone 9 (Standard)	Reference Standards Apoptosis Endogenous Metabolite	Cardiovascular Disease
Coenzyme Q9 (Standard) is the analytical standard of Coenzyme Q9. This product is intended for research and analytical applications. Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis .

Spiraprilat	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Spiraprilat is a potent angiotensin-converting enzyme (ACE) inhibitor. Spiraprilat has ability to improve left ventricular (LV) function and metabolism in anesthetized open-chest dogs with acute ventricular failure (ALVF) .

NHE-1-IN-2	Na+/H+ Exchanger (NHE)	Neurological Disease
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC₅₀ of 0.78 μM. NHE-1-IN-2 alleviates left ventricular systolic dysfunction in mice model of heart failure .

KS370G	TGF-beta/Smad	Cardiovascular Disease
KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy .

Flosequinan BTS 49465; Flosequinon	PKC	Cardiovascular Disease
Flosequinan is a balanced vasodilator. Flosequinan not only significantly reduces systemic vascular resistance, but also significantly reduces the beating component of left ventricular afterload, characteristic impedance and arterial wave reflection, which can be used in the research of acute heart failure .

Velaresol BW 12C; 12C79; BW 12C79	Hemoglobin	Others
Velaresol (BW 12C) is a potent left-shifting anti-sickling compound in vitro . Sickle cell disease is an inherited disorder of the hemoglobin molecule. When hemoglobin molecules are exposed to a variety of environments, the red blood cell hemoglobin polymerizes, twists, and morphs into a sickle shape.

Indapamide (Standard) 1 Publications Verification	Reference Standards Potassium Channel	Cardiovascular Disease
Indapamide (Standard) is the analytical standard of Indapamide. This product is intended for research and analytical applications. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy .

DL-Norepinephrine-d3 hydrochloride	Adrenergic Receptor	Neurological Disease
DL-Norepinephrine-d₃ hydrochloride is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine hydrochloride after being labeled with tritium can be used as a tracer for the research on Parkinson's disease.

Myosin-IN-1	Myosin	Cardiovascular Disease
Myosin-IN-1 (compound F10) is a Myosin inhibitor that specifically targets cardiac myosin. Myosin-IN-1 stabilizes the biochemical and structural closed state of the cardiac myosin motor domain and reduces myocardial force production and calcium sensitivity in vitro. Myosin-IN-1 acts as a negative inotropic agent in isolated Langendroff-perfused rat hearts, reducing stress in isolated myofilaments and left ventricular pressure development. Myosin-IN-1 can be used in heart failure research .

BI-9740	Cathepsin Elastase	Inflammation/Immunology
BI-9740 is an orally active and selective cathepsin C (CatC) inhibitor, with an IC₅₀ of 0.6 nM in mice and 2.6 nM in rats. BI-9740 can inhibit the production of active neutrophil elastase. Additionally, BI-9740 is capable of reducing the activities of neutrophil elastase and cathepsin G in the bone marrow of rats, alleviating pathological damage to grafts after heart transplantation, shortening the reperfusion time, and improving left ventricular function. BI-9740 can be used in research related to organ transplantation .

Vinyl-L-NIO hydrochloride L-VNIO hydrochloride	NO Synthase NADPH Oxidase	Cardiovascular Disease Neurological Disease
Vinyl-L-NIO (L-VNIO) hydrochloride is a neuronal nitric oxide synthase (NOS) inhibitor with a rat K_i of 0.10 μM. Vinyl-L-NIO hydrochloride inhibits NADPH oxidase activity, attenuates renal fibrosis, inflammation, oxidative stress indices, and albuminuria. Vinyl-L-NIO hydrochloride can be used for the research of parkinson's disease, migraine headache, and hypertension .

L-3373	Potassium Channel	Others
L-3373 is a voltage-dependent potassium channel inhibitor with activity that reduces the effective refractory period and the dispersion of monophasic action potential duration, while significantly reducing susceptibility to ventricular fibrillation in a cat model of left ventricular hypertrophy.

GW542573X	Potassium Channel	Neurological Disease
GW542573X is a potent and selective Ca ²⁺-activated K ⁺ 2 (SK2) channels activator. GW542573X induces the Ca ²⁺-response curve of hSK1 that left-shifted from an EC₅₀ (Ca ²⁺) value of 410 nM to 240 nM .

PG 116800 PG 530742; PGE 530742; PGE 7113313	MMP	Cardiovascular Disease
PG 116800 (PGE 530742; PGE 7113313) is an orally active, selective and high-affinity inhibitor of MMP. PG 116800 acts as an inhibitor of ventricular remodeling, reduces left ventricular volumes and infarct zone collagen content, and improves ejection fraction. PG 116800 is generally well tolerated, but is associated with higher rates of arthralgia, joint stiffness, and dyspepsia. PG 116800 can be used for the research of myocardial infarction .

Xamoterol Corwin; ICI 118587	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
Xamoterol (Corwin; ICI 118587) is an orally active and selective β₁-adrenoceptor partial agonist. Xamoterol acts as agonist at low sympathetic tone, antagonist at high sympathetic tone, with context-dependent cardiovascular effects including modulated heart rate, blood pressure, and cardiac output. Xamoterol can be used for the research of heart failure, postural hypotension, and ischemic heart disease .

AC-SDKP-NH2	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
AC-SDKP-NH2 is a substrate peptide of Angiotensin converting enzyme (ACE). AC-SDKP-NH2 has anti-inflammatory and anti-fibrotic activities. AC-SDKP-NH2 directly acts on tissues and prevents or reverses them from excessive fibrosis, but fails to reduce blood pressure and left ventricular hypertrophy (LVH). AC-SDKP-NH2 attenuates inflammation and cell differentiation, proliferation and migration, therefore reducing fibrosis in the heart, vessels and kidneys in mice model. AC-SDKP-NH2 can be used for cardiovascular diseases such as hypertension research .

Cat. No.	Product Name	Target	Research Area

HY-P1636

Hirudin (54-65)	Thrombin YAP Calcium Channel	Metabolic Disease
Hirudin (54-65) is a thrombin antagonist and YAP suppressor with anticoagulatory properties.Hirudin (54-65) blocks thrombin's anion binding site, acts on soluble and thrombus-bound thrombin.Hirudin (54-65) suppresses thrombin-induced profibrotic YAP activity, reduces YAP expression, nuclear translocation, and downstream effector signaling in vascular endothelial cells.Hirudin (54-65) ameliorates obstructive cholestasis, attenuates liver fibrosis symptoms, fibrosis-associated angiogenesis, and endothelial-to-mesenchymal transition.Hirudin (54-65) reduces liver inflammation and tissue hypoxia.Hirudin (54-65) promotes extracellular calcium influx through L-type calcium channels in canine coronary artery smooth muscle, mediates contraction.Hirudin (54-65) induces endothelium-independent contraction of canine coronary arterial segments; this response is not affected by indomethacin pretreatment.Hirudin (54-65) can be used for the research of liver obstructive cholestasis, liver fibrosis .

HY-P3775

a-Bag Cell Peptide (1-7)	Peptides	Neurological Disease
a-Bag Cell Peptide (1-7) is a NH2-terminal fragment α-bag cell peptide. α-bag cell peptide can inhibit the left upper quadrant (LUQ) neurons and the depolarization of the bag cells . α-Bag Cell Peptide Fragment

HY-P11297

AC-SDKP-NH2	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
AC-SDKP-NH2 is a substrate peptide of Angiotensin converting enzyme (ACE). AC-SDKP-NH2 has anti-inflammatory and anti-fibrotic activities. AC-SDKP-NH2 directly acts on tissues and prevents or reverses them from excessive fibrosis, but fails to reduce blood pressure and left ventricular hypertrophy (LVH). AC-SDKP-NH2 attenuates inflammation and cell differentiation, proliferation and migration, therefore reducing fibrosis in the heart, vessels and kidneys in mice model. AC-SDKP-NH2 can be used for cardiovascular diseases such as hypertension research .

HY-P10795

NK-2 Antibiotic NK 2	Parasite Bacterial Fungal	Infection
NK-2 (Antibiotic NK 2), a shortened linear amphipathic NK-Lysin analog (comprising residues 39 to 65 of NK-lysin), is an antimicrobial peptide that exhibits potent activities against trypanosoma cruzi, Candida albicans, gram-positive and gram-negative bacteria. NK-2 can kill trypanosomes residing inside the human glioblastoma cell line 86HG39, left the host cells apparently unharmed .

HY-P2601A

Tyr-α-CGRP (human) TFA	CGRP Receptor	Others
Tyr-α-CGRP (human) TFA is an N-terminally extended human α-CGRP analog. Tyr-α-CGRP (human) TFA can bind to membrane preparations from rat brain and spleen with IC₅₀ values of 0.2 nM and 0.5 nM, respectively, and induce positive chronotropic and inotropic effects in isolated guinea pig right and left atria with EC₅₀ values of 282 nM and 74 nM, respectively. Tyr-α-CGRP (human) TFA also inhibits contractile responses in rat vas deferens with an EC₅₀ value of 1.9 nM .

HY-P3776

a-Bag Cell Peptide (1-8)	Peptides	Neurological Disease
a-Bag Cell Peptide (1-8) is a NH2-terminal fragment α-bag cell peptide. α-bag cell peptide can inhibit the left upper quadrant (LUQ) neurons and the depolarization of the bag cells .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70191

	Lefty-A/TGF-beta 4 Protein, Human (HEK293, His) rHuleft-right determination factor 2, His; left-right determination factor 2; Endometrial bleeding-associated factor; left-right determination factor A; Protein lefty-2; Protein lefty-A; Transforming growth factor beta-4; TGF-beta-4; leftY2; EBAF; leftA; leftYA; TGFB4	Human	HEK293
	Lefty-A/TGF-beta 4 Protein, Human is a secreted protein belonging to the transforming growth factor-beta (TGF-β) family, which plays an important role in the development of human left-right axis. Lefty-A/TGF-beta 4 Protein, Human (HEK293, His) is a recombinant Lefty-A/TGF-β 4 protein expressed by HEK293 with an N-6*His tag.

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Cat. No.	Product Name	Chemical Structure

HY-N7142S

DL-Norepinephrine-d6 hydrochloride

DL-Norepinephrine-d₆ hydrochloride is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine hydrochloride after being labeled with tritium can be used as a tracer for the research on Parkinson's disease .

HY-17498S

Atenolol-d7
Atenolol-d₇ is the deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-N7142S3

DL-Norepinephrine-d6
DL-Norepinephrine-d₆ is the deuterium labeled DL-Norepinephrine. DL-Norepinephrine is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine after being labeled with tritium can be used as a tracer for the research on Parkinson's disease .

HY-N7142S1

DL-Norepinephrine-d3 hydrochloride

DL-Norepinephrine-d₃ hydrochloride is the deuterium labeled DL-Norepinephrine hydrochloride. DL-Norepinephrine hydrochloride is an external racemic catecholamine neurotransmitter, which is an equal mixture of the left-handed (L-, with activity) and right-handed (D-, with very low or no activity) stereoisomers. DL-Norepinephrine hydrochloride after being labeled with tritium can be used as a tracer for the research on Parkinson's disease.

HY-B0259S

(rac)-Indapamide-d3
(rac)-Indapamide-d₃ is a labelled racemic Indapamide. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy .

HY-B0259S3

Indapamide-d6
Indapamide-d6 is a deuterated labeled Indapamide . Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy .

HY-B0259S1

Indapamide-13C,d3
Indapamide- ¹³C,d₃ is ¹³C and deuterium labeled Indapamide. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy .

HY-17498S1

Atenolol-d6
Atenolol-d₆ ((RS)-Atenolol-d₆) is deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-17498S3

Atenolol-13C6
Atenolol- ¹³C₆ ((RS)-Atenolol- ¹³C₆) is ¹³C labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

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