1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Coenzyme Q9

Coenzyme Q9 (Synonyms: Ubiquinone Q9; CoQ9; Ubiquinone 9)

Cat. No.: HY-101415 Purity: ≥98.0%
Handling Instructions

Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis.

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Coenzyme Q9 Chemical Structure

Coenzyme Q9 Chemical Structure

CAS No. : 303-97-9

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1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 420 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Coenzyme Q9 (5 mg/kg; p.o.; once a day for 4 weeks) reduces myocardial ischemia/reperfusion injury[2].
CoQ10 and CoQ9 are components of themitochondrial respiratory chain in mammals and can regulate some mitochondrial proteins/functions. Soybean, corn, and rapeseed oils are very rich sources of CoQ10, whereas CoQ9 has been found in high concentrations in corn oil[3].
The lack of a functional CoQ9 protein in homozygous CoQ9 mutant (CoQ9(X/X)) mice causes a severe reduction in the CoQ7 protein and a widespread CoQ deficiency and accumulation of demethoxyubiquinone. The deficit in CoQ induces a brain-specific impairment of mitochondrial bioenergetics performance, a reduction in respiratory control ratio, ATP levels and ATP/ADP ratio and specific loss of respiratory complex I. These effects lead to neuronal death and demyelinization with severe vacuolization and astrogliosis in the brain of CoQ9 (X/X) mice that consequently die between 3 and 6 months of age[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Hartley guinea pigs of about 350-400 g body weight[2]
Dosage: 5 mg/kg of body weight
Administration: P.o.; once a day for 4 weeks
Result: Nutritional supplementation of CoQ9 can reduce myocardial ischemia/reperfusion injury to the same extent as CoQ10.
Molecular Weight

795.23

Formula

C₅₄H₈₂O₄

CAS No.
SMILES

O=C1C(OC)=C(OC)C(C(C)=C1C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 33.33 mg/mL (41.91 mM; Need ultrasonic)

DMSO : 5 mg/mL (6.29 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2575 mL 6.2875 mL 12.5750 mL
5 mM 0.2515 mL 1.2575 mL 2.5150 mL
10 mM 0.1257 mL 0.6287 mL 1.2575 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: ≥98.0%

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Keywords:

Coenzyme Q9Ubiquinone Q9 CoQ9 Ubiquinone 9Coenzyme Q 9Coenzyme Q-9Ubiquinone Q 9Ubiquinone Q-9CoQ9CoQ 9CoQ-9Ubiquinone9Ubiquinone 9Ubiquinone-9Endogenous MetaboliterodentsamphipathicelectrontransportchainendogenousantioxidantleftventricularInhibitorinhibitorinhibit

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Product Name:
Coenzyme Q9
Cat. No.:
HY-101415
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