593-56-6
Chemical Structure
Methoxyamine hydrochloride
Synonym(s): O-Methylhydroxylamine hydrochloride; TRC-102 hydrochloride
- CAS No.: 593-56-6
- Formula:CH6ClNO
- Molecular Weight:83.52
IUPAC Name: O-methylhydroxylamine hydrochloride
InChIKey: XNXVOSBNFZWHBV-UHFFFAOYSA-N
SMILES: NOC.Cl
Biological Activity: Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents[1][2].
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Methoxyamine hydrochloride | 98.0% | Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents. | ||||||||||||||||||||
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Methoxyamine hydrochloride (Standard) | ≥98% | Methoxyamine hydrochloride (Standard) is the analytical standard of Methoxyamine hydrochloride. This product is intended for research and analytical applications. Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents. | ||||||||||||||||||||
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Methoxyamine-d3 Hydrochloride | 99.54% | Methoxyamine-d3 (O-Methylhydroxylamine-d3) hydrochloride is the deuterium labeled Methoxyamine hydrochloride. Methoxyamine hydrochloride is an orally active and potent base excision repair (BER) inhibitor. | ||||||||||||||||||||
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Similarity Score 0.80
HY-W010619SO-Ethylhydroxylamine-d5 hydrochloride -
Similarity Score 0.77
HY-Y1401SMethyl carbamate-d3 -
Similarity Score 0.74
HY-W705485N-Methylmethan-d3-amine hydrochloride -
Similarity Score 0.73
HY-W069504S1n-Propyl-amine-d3 Hydrochloride -
Similarity Score 0.70
HY-34449SMethylboronic acid-d3 -
Similarity Score 0.70
HY-Y1838SMethoxytrimethylsilane-d3 -
Similarity Score 0.70
HY-W7008763-(Methoxy-d3)propan-1-ol -
Similarity Score 0.69
HY-41074N,O-Dimethylhydroxylamine hydrochloride -
Similarity Score 0.68
HY-Y1401Methyl carbamate -
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References
- [1]. Sameer Agnihotri, et al. ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents. Cancer Discov. 2014 Oct;4(10):1198-213. [Content Brief]
- [2]. Samideh Khoei, et al. Effects of resveratrol and methoxyamine on the radiosensitivity of iododeoxyuridine in U87MG glioblastoma cell line. Exp Biol Med (Maywood). 2016 Jun;241(11):1229-36. [Content Brief]
