223749-46-0
223749-46-0
Chemical Structure
HMR 1556
- CAS No.: 223749-46-0
- Formula:C17H24F3NO5S
- Molecular Weight:411.44
IUPAC Name: N-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)chroman-4-yl)-N-methylmethanesulfonamide
InChIKey: SRZRLJWUQFIZRH-LSDHHAIUSA-N
SMILES: CS(N([C@H]1C2=CC(OCCCC(F)(F)F)=CC=C2OC(C)(C)[C@@H]1O)C)(=O)=O
Biological Activity: HMR 1556, a chromanol derivative, is a potent IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HMR 1556 | 99.95% | HMR 1556, a chromanol derivative, is a potent IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively. | ||||||||||||||||||||
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HMR 1556 (Standard) | ≥98% | HMR 1556 (Standard) is the analytical standard of HMR 1556 (HY-106369). This product is intended for research and analytical applications. HMR 1556, a chromanol derivative, is a potent IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively. | ||||||||||||||||||||
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References
- [1]. Thomas GP, et al. HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J Cardiovasc Pharmacol. 2003 Jan;41(1):140-7. [Content Brief]
- [2]. Gerlach U,et al. Synthesis and activity of novel and selective I(Ks)-channel blockers. J Med Chem. 2001 Nov 8;44(23):3831-7. [Content Brief]
