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longifolia

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By Targets:	Akt (1) Apoptosis (1) Bacterial (1) Bcl-2 Family (1) Drug Derivative (1) Fungal (1) GSK-3 (1) NF-κB (2) Parasite (3) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (3) Infection (6) Inflammation/Immunology (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N4327

Eurycomalactone	NF-κB Apoptosis Akt Bcl-2 Family	Infection Inflammation/Immunology
Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia* Jack. Eurycomalactone is a potent NF-κB* inhibitor with an IC₅₀ value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394) .

HY-N1434

Methyl p-coumarate Methyl 4-hydroxycinnamate	Fungal	Infection Cancer
Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens .

HY-N12077

Eurycomanol 2-O-β-D-glucopyranoside	Parasite	Infection
Eurycomanol 2-O-β-D-glucopyranoside (compound 4) is a natural product that can be obtained from Eurycoma longifolia. Eurycomanol 2-O-β-D-glucopyranoside has the potential for anti-malarial research .

HY-N11016

1-Methoxymethyl-β-carboline	Others	Others
1-Methoxymethyl-β-carboline is a natural product isolated from the root of Eurycoma longifolia .

HY-N9320

13,21-Dihydroeurycomanone	Parasite	Infection
13,21-Dihydroeurycomanone, a natural compound isolated from Eurycoma longifolia root, possesses anti-parasite activity for Plasmodium falciparum and Toxoplasma gondii .

HY-N1600

16(R/S)-Hydroxy-3,13Z-kolavadien-15,16-olide-2-one	Others	Others
16(R/S)-Hydroxy-3,13Z-kolavadien-15,16-olide-2-one (compound 9) is a diterpene compound isolated from the unripe fruits of Polyalthia longifolia var. pendula .

HY-N7183

9-Hydroxycanthin-6-one	NF-κB GSK-3 β-catenin Wnt	Cancer
9-Hydroxycanthin-6-one is a β-carboline alkaloid. 9-Hydroxycanthin-6-one can be isolated from the roots of E. longifolia. 9-Hydroxycanthin-6-one inhibits TNF-α-induced activation of the NF-κB pathway. 9-Hydroxycanthin-6-one activates GSK3β independently of CK1α, drives phosphorylation and degradation of β-catenin, and inhibits the Wnt signaling pathway. 9-Hydroxycanthin-6-one exerts selective cytotoxicity against Wnt-dependent colon cancer cells. 9-Hydroxycanthin-6-one can be used in studies related to colon cancer .

HY-N4328

Pasakbumin B 13α-(21)-Epoxyeurycomanone	Others	Inflammation/Immunology
Pasakbumin B, a bioactive compound from Eurycoma longifolia Jack, exhibits potent antiulcer activity .

HY-N7173

7-Methoxy-β-carboline-1-propionic acid	Parasite	Infection
7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .

HY-N8774

1-Hydroxy-9-methoxycanthin-6-one	Others	Others
1-Hydroxy-9-methoxycanthin-6-one is a natural product that can be isolated from the roots of Eurycoma longifolia .

HY-126613

Laurycolactone A	Others	Others
Laurycolactone A is a quassinoid with a C18 basic skeleton. Laurycolactone A can be isolated from Eurycoma longifolia .

HY-N4326

14,15 β-Dihydroxyklaineanone	Others	Cancer
14,15 D-dihydroxyklaineanone, a quassinoid isolated from the root of Eurycoma longifolia, possesses anti-cancer activity .

HY-N9151

(4->2)-Abeo-16-hydroxycleroda-2,13-dien-15,16-olide-3-al	Others	Others
(4->2)-Abeo-16-hydroxycleroda-2,13-dien-15,16-olide-3-al is a Diterpenoids product that can be isolated from the unripe fruits of Polyalthia longifolia var. pendula .

HY-N19041

*Eurycoma longifolia* extract**	Bacterial	Infection Inflammation/Immunology
The active ingredients in Eurycoma longifolia extract include quassinolides (such as tongkatarin), alkaloids, triterpenoids, complex peptides, and saponins. Eurycoma longifolia extract possesses antioxidant, anti-inflammatory, and antibacterial properties, helping to enhance overall immunity and reduce inflammation. Eurycoma longifolia extract is also being used in research to improve athletic performance, promote sexual health, and alleviate fatigue.

HY-177428

Jasmonoyl-valine JA-Val	Drug Derivative	Others
Jasmonoyl-valine (JA-Val) is one of the amino acid conjugates of jasmonic acid. Jasmonoyl-valine can be extracted from the alpine plant Saxifraga longifolia. Jasmonoyl-valine may participate in light protection or regulation of photosynthetic mechanisms .

Eurycomalactone	other families Classification of Application Fields Terpenoids Diterpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	NF-κB Apoptosis Akt Bcl-2 Family
Eurycomalactone is an active quassinoid could be isolated from Eurycoma longifolia* Jack. Eurycomalactone is a potent NF-κB* inhibitor with an IC₅₀ value of 0.5 μM. Eurycomalactone inhibits protein synthesis and depletes cyclin D1. Eurycomalactone enhances radiosensitivity through arrest cell cycle at G2/M phase and delayed DNA double-strand break repair. Eurycomalactone inhibits the activation of AKT/NF-κB signaling, induces apoptosis and enhances chemosensitivity to Cisplatin (HY-17394) .

Methyl p-coumarate Methyl 4-hydroxycinnamate	Infection Monophenols other families Classification of Application Fields Simple Phenylpropanols Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	Fungal
Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens .

Eurycomanol 2-O-β-D-glucopyranoside	Simaroubaceae Plants Saccharides Monosaccharides Source Classification	Parasite
Eurycomanol 2-O-β-D-glucopyranoside (compound 4) is a natural product that can be obtained from Eurycoma longifolia. Eurycomanol 2-O-β-D-glucopyranoside has the potential for anti-malarial research .

1-Methoxymethyl-β-carboline	Alkaloids Simaroubaceae Pyridine Alkaloids Plants Source Classification	Others
1-Methoxymethyl-β-carboline is a natural product isolated from the root of Eurycoma longifolia .

13,21-Dihydroeurycomanone	Infection other families Classification of Application Fields Ketones, Aldehydes, Acids Eurycoma longifolia Jack Plants Disease Research Fields Source Classification	Parasite
13,21-Dihydroeurycomanone, a natural compound isolated from Eurycoma longifolia root, possesses anti-parasite activity for Plasmodium falciparum and Toxoplasma gondii .

9-Hydroxycanthin-6-one	Structural Classification Alkaloids Simaroubaceae Other Alkaloids Plants Source Classification	NF-κB GSK-3 β-catenin Wnt
9-Hydroxycanthin-6-one is a β-carboline alkaloid. 9-Hydroxycanthin-6-one can be isolated from the roots of E. longifolia. 9-Hydroxycanthin-6-one inhibits TNF-α-induced activation of the NF-κB pathway. 9-Hydroxycanthin-6-one activates GSK3β independently of CK1α, drives phosphorylation and degradation of β-catenin, and inhibits the Wnt signaling pathway. 9-Hydroxycanthin-6-one exerts selective cytotoxicity against Wnt-dependent colon cancer cells. 9-Hydroxycanthin-6-one can be used in studies related to colon cancer .

Pasakbumin B 13α-(21)-Epoxyeurycomanone	Natural Products other families Eurycoma longifolia Jack Plants	Others
Pasakbumin B, a bioactive compound from Eurycoma longifolia Jack, exhibits potent antiulcer activity .

7-Methoxy-β-carboline-1-propionic acid	Alkaloids other families Ketones, Aldehydes, Acids Eurycoma longifolia Jack Plants	Parasite
7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia .

Laurycolactone A	Natural Products Simaroubaceae Plants	Others
Laurycolactone A is a quassinoid with a C18 basic skeleton. Laurycolactone A can be isolated from Eurycoma longifolia .

14,15 β-Dihydroxyklaineanone	other families Classification of Application Fields Terpenoids Diterpenoids Plants Disease Research Fields Cancer Source Classification	Others
14,15 D-dihydroxyklaineanone, a quassinoid isolated from the root of Eurycoma longifolia, possesses anti-cancer activity .

(4->2)-Abeo-16-hydroxycleroda-2,13-dien-15,16-olide-3-al	Terpenoids Diterpenoids Plants Annonaceae Polyalthia longifolia Source Classification	Others
(4->2)-Abeo-16-hydroxycleroda-2,13-dien-15,16-olide-3-al is a Diterpenoids product that can be isolated from the unripe fruits of Polyalthia longifolia var. pendula .

*Eurycoma longifolia* extract**	Structural Classification Extract	Bacterial
The active ingredients in Eurycoma longifolia extract include quassinolides (such as tongkatarin), alkaloids, triterpenoids, complex peptides, and saponins. Eurycoma longifolia extract possesses antioxidant, anti-inflammatory, and antibacterial properties, helping to enhance overall immunity and reduce inflammation. Eurycoma longifolia extract is also being used in research to improve athletic performance, promote sexual health, and alleviate fatigue.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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longifolia

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