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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
m 1 G
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "m 1 G" in MCE Product Catalog:
4
4 Cited Publications
PHA-793887 is a CDK inhibitor (with IC50 values of 8 nM for Cdk2, 60 nM for Cdk1, 62 nM for Cdk4, 138 nM for Cdk9). PHA-793887 inhibits purified GSK3β (IC50 79 nM). PHA-793887 reduces the phosphorylation level of nucleophosmin/cdc6, induces G1/G2/M phase arrest, and triggers Apoptosis by activating Caspase-3. PHA-793887 exhibits anticancer activity against leukemia. PHA-793887 can be used in research related to acute leukemia, chronic myeloid leukemia, and advanced/metastatic solid tumors .
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Cat. No.: HY-178462
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Hsp70/FoxM1-IN-1 (Compound 7d) is a potent heat shock protein 70 (Hsp70) and Forkhead box M1 (FoxM1) dual inhibitor. Hsp70/FoxM1-IN-1 demonstrates significant antiproliferative and pro-apoptotic effects in multiple solid tumor models (e.g., breast, colorectal cancer), particularly for tumors co-overexpressing Hsp70/FoxM1 .
Cat. No.: HY-152157
CAS No.: 1818868-23-3
HIV-1 inhibitor-52 is a potent broad-spectrum HIV-1 activity inhibitor with EC50s of 1.6 nM-6.4 nM for WT HIV-1, HIV-1 V370A, HIV-1 ΔV370, HIV-1 V362I/V370A, HIV-1 T332S/V362I/prR41G, HIV-1 A326T/V362I/V370A, HIV-1 R361K/V362I/L363M .
Cat. No.: HY-N3248
CAS No.: 81371-54-2
Synonyms: Momordicacoside G
Cat. No.: HY-148961
CAS No.: 1438242-59-1
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HTL-9936 is a selective M1 muscarinic acetylcholine receptor (M1-mAChR) agonist. HTL-9936 is promising for research of neurodegenerative disorders (e.g., Alzheimer’s) .
Cat. No.: HY-161067
EGFR-IN-96 (compound 7a) is a thieno[2,3-d]pyrimidine EGFR inhibitor that can induce apoptosis. EGFR-IN-96 arrests the growth of HepG2 cells in the S phase and G2/M phase, and inhibits the growth of cancer cells bearing EGFR wild-type and EGFR T790M .
Cat. No.: HY-P4905
CAS No.: 891198-38-2
Cat. No.: HY-150590
CAS No.: 2028300-31-2
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20S Proteasome-IN-2 is a human 20S proteasome inhibitor. 20S Proteasome-IN-2 shows high selectivity to its β5 subunit with the IC50 of 0.18 μM. 20S Proteasome-IN-2 displays anti-proliferative effect in vitro and in vivo, and arrests cell cycle at G2/M .
Cat. No.: HY-E71730
Synonyms: RNA m1G Demethylase (D135S)
Research Areas:
AlkB (D135S), Nuclease-free (RNA m1G Demethylase (D135S)) is a nuclease-free N1-methylguanosine (m1G) demethylase that specifically removes the methyl group from m1G residues in small non-coding RNAs. AlkB (D135S), Nuclease-free effectively promotes the reverse transcription of small non-coding RNAs and supports high-throughput sequencing methods such as CPA-seq. AlkB (D135S), Nuclease-free can be used for the precise detection and quantitative analysis of methylated small non-coding RNAs that are easily missed by conventional methods .
Cat. No.: HY-180544
TrmD-IN-1 (compound 8h) is a selective Staphylococcus aureus tRNA m1 G37 methyltransferase (TrmD) inhibitor with a KD of 2.48 μM and an IC50 of 1.16 μM. TrmD-IN-1 exhibits selectivity over E. coli (KD > 30 μM) and H. influenzae TrmD (KD > 30 μM) and Trm5 (IC50 > 30 μM) .
Cat. No.: HY-E71729
Synonyms: RNA m22G Demethylase (D135S/L118V)
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AlkB (D135S/L118V), Nuclease-free (RNA m22G Demethylase (D135S/L118V)) is a nuclease-free modified demethylase. AlkB (D135S/L118V), Nuclease-free exhibits catalytic activity toward N2,N2-dimethylguanosine (m22G), N1-methylguanosine (m1G) and N1-methyladenosine (m1A). AlkB (D135S/L118V), Nuclease-free efficiently removes m1G and m1A modifications on RNA, and can also selectively convert m22G to N2-methylguanosine (m2G), thereby significantly reducing the level of m22G in transfer RNA (tRNA). AlkB (D135S/L118V), Nuclease-free greatly reduces sequencing bias and improves the efficiency of high-throughput tRNA sequencing .
Cat. No.: HY-E71961
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6G-Fructosyltransferase (EC 2.4.1.243) is a transferase that can convert [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside and [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside into [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside and [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0, n >= 0).
Cat. No.: HY-11001A
CAS No.: 718630-60-5
PHA-793887 hydrochloride is a CDK inhibitor (with IC50 values of 8 nM for Cdk2, 60 nM for Cdk1, 62 nM for Cdk4, 138 nM for Cdk9). PHA-793887 hydrochloride inhibits purified GSK3β (IC50 79 nM). PHA-793887 hydrochloride reduces the phosphorylation level of nucleophosmin/cdc6, induces G1/G2/M phase arrest, and triggers Apoptosis by activating Caspase-3. PHA-793887 hydrochloride exhibits anticancer activity against leukemia. PHA-793887 hydrochloride can be used in research related to acute leukemia, chronic myeloid leukemia, and advanced/metastatic solid tumors .
Cat. No.: HY-184580
Research Areas:
KMG-732 is a dual-target inhibitor that targets GAK and β-tubulin, with Kd values of 12.0 nM and 19.3 μM, respectively. KMG-732 exhibits broad-spectrum antiproliferative activity in various human cancer cell lines and directly binds to purified tubulin in vitro. KMG-732 reduces the phosphorylation level of AP2M1, induces G2/M phase cell cycle arrest, disrupts the microtubule network, and inhibits cancer cell migration and invasion. KMG-732 shows significant antitumor activity in organoid and in vivo xenograft models. KMG-732 can be used for cancer research .
Cat. No.: HY-184445
Antibacterial agent 355 is a bacterial tRNA (m 1G37) methyltransferase (TrmD) inhibitor with an IC50 of 0.85 μM against E. coli. Antibacterial agent 355 shows weak inhibitory activity against human Trm5, with an approximate IC50 of 1.88 mM. Antibacterial agent 355 inhibits the growth of bacterial strains expressing TrmD. Antibacterial agent 355 can be used for the research of bacterial infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
