HIV-1 inhibitor-52
HIV-1 inhibitor-52 is a potent broad-spectrum HIV-1 activity inhibitor with EC50s of 1.6 nM-6.4 nM for WT HIV-1, HIV-1 V370A, HIV-1 ΔV370, HIV-1 V362I/V370A, HIV-1 T332S/V362I/prR41G, HIV-1 A326T/V362I/V370A, HIV-1 R361K/V362I/L363M.
For research use only. We do not sell to patients.
- CAS No.: 1818868-23-3
- Formula: C46H72FNO5S
- Molecular Weight:770.13
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HIV-1 (WT) 1.6 nM (EC50) |
HIV-1 V370A 3.0 nM (EC50) |
HIV-1 ΔV370 5.1 nM (EC50) |
HIV-1 V362I/V370A 2.0 nM (EC50) |
HIV-1 T332S/V362I/prR41G 6.4 nM (EC50) |
HIV-1 A326T/V362I/V370A 4.3 nM (EC50) |
HIV-1 R361K/V362I/L363M 4.5 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
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| MT2 | CC50 |
16 μM
Compound: 27
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Cytotoxicity against human MT2 cells assessed as reduction in cell viability
Cytotoxicity against human MT2 cells assessed as reduction in cell viability
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[PMID: 36441509] |
HIV-1 inhibitor-52 (5 mg/kg; po) has a Cmax of 0.83 μM and an AUC of 8.11 μM·h for rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male sprague-dawley rats[1]
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Dosage:1 mg/kg
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Administration:IV
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Result:Had a T1/2 of 4.2 hours, a CL of 3.5 mL/min•kg, and a Vss of 0.8 L/kg for rats.
Chemical Information
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CAS No. 1818868-23-3
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Molecular Weight 770.13
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Formula C46H72FNO5S
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SMILES
O[C@]1(CC[C@@H](CC1)S(C)(=O)=O)CCN[C@]23[C@@]([C@@H](CC3)C(C)=C)([H])[C@]4([H])[C@@](CC2)([C@]5([C@]([C@@]6([C@@](C(C)(C(C7=CC[C@@](C(O)=O)(CF)CC7)=CC6)C)([H])CC5)C)([H])CC4)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-1 inhibitor-52 Related Classifications
HY-152157 Related Classifications
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