2. Anti-infection
  3. HIV
  4. HIV-1 inhibitor-52

HIV-1 inhibitor-52 is a potent broad-spectrum HIV-1 activity inhibitor with EC50s of 1.6 nM-6.4 nM for WT HIV-1, HIV-1 V370A, HIV-1 ΔV370, HIV-1 V362I/V370A, HIV-1 T332S/V362I/prR41G, HIV-1 A326T/V362I/V370A, HIV-1 R361K/V362I/L363M.

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HIV-1 inhibitor-52 Chemical Structure

HIV-1 inhibitor-52 Chemical Structure

CAS No. : 1818868-23-3

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HIV-1 inhibitor-52 Related Antibodies

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Description

HIV-1 inhibitor-52 is a potent broad-spectrum HIV-1 activity inhibitor with EC50s of 1.6 nM-6.4 nM for WT HIV-1, HIV-1 V370A, HIV-1 ΔV370, HIV-1 V362I/V370A, HIV-1 T332S/V362I/prR41G, HIV-1 A326T/V362I/V370A, HIV-1 R361K/V362I/L363M[1].

IC50 & Target[1]

HIV-1 (WT)

1.6 nM (EC50)

HIV-1 V370A

3.0 nM (EC50)

HIV-1 ΔV370

5.1 nM (EC50)

HIV-1 V362I/V370A

2.0 nM (EC50)

HIV-1 T332S/V362I/prR41G

6.4 nM (EC50)

HIV-1 A326T/V362I/V370A

4.3 nM (EC50)

HIV-1 R361K/V362I/L363M

4.5 nM (EC50)

In Vivo

HIV-1 inhibitor-52 (compound 26; 1 mg/kg; IV) has a T1/2 of 4.2 hours, a CL of 3.5 mL/min·kg, and a Vss of 0.8 L/kg for rats[1].
HIV-1 inhibitor-52 (5 mg/kg; po) has a Cmax of 0.83 μM and an AUC of 8.11 μM·h for rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male sprague-dawley rats[1]
Dosage: 1 mg/kg
Administration: IV
Result: Had a T1/2 of 4.2 hours, a CL of 3.5 mL/min•kg, and a Vss of 0.8 L/kg for rats.
Molecular Weight

770.13

Formula

C46H72FNO5S
CAS No.
SMILES

O[C@]1(CC[C@@H](CC1)S(C)(=O)=O)CCN[C@]23[C@@]([C@@H](CC3)C(C)=C)([H])[C@]4([H])[C@@](CC2)([C@]5([C@]([C@@]6([C@@](C(C)(C(C7=CC[C@@](C(O)=O)(CF)CC7)=CC6)C)([H])CC5)C)([H])CC4)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HIV-1 inhibitor-52 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HIV-1 inhibitor-521818868-23-3HIVHuman immunodeficiency virusV370AΔV370V362I/V370AT332S/V362I/prR41GA326T/V362I/V370A R361K/V362I/L363MInhibitorinhibitorinhibit

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