1438242-59-1
1438242-59-1
Chemical Structure
HTL-9936
- CAS No.: 1438242-59-1
- Formula:C20H35N3O3
- Molecular Weight:365.51
IUPAC Name: ethyl (S)-4-(4-((1-methylcyclobutyl)carbamoyl)piperidin-1-yl)azepane-1-carboxylate
InChIKey: AQEAWDQQWHVFAX-KRWDZBQOSA-N
SMILES: CC1(CCC1)NC(C2CCN([C@@H]3CCN(CCC3)C(OCC)=O)CC2)=O
Biological Activity: HTL-9936 is a selective M1 muscarinic acetylcholine receptor (M1-mAChR) agonist. HTL-9936 is promising for research of neurodegenerative disorders (e.g., Alzheimer’s)[1][2].
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HTL-9936 | HTL-9936 is a selective M1 muscarinic acetylcholine receptor (M1-mAChR) agonist. HTL-9936 is promising for research of neurodegenerative disorders (e.g., Alzheimer’s). | |||||||||||||||||||||
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References
- [1]. Nguyen HTM, et al. Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits. Br J Pharmacol. 2024 Jul;181(14):2114-2142. [Content Brief]
- [2]. Brown AJH, et al. From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. Cell. 2021 Nov 24;184(24):5886-5901.e22. [Content Brief]
Keywords
