1191-25-9
Chemical Structure
6-Hydroxyhexanoic acid
Synonym(s): 6-HHA
- CAS No.: 1191-25-9
- Formula:C6H12O3
- Molecular Weight:132.16
IUPAC Name: 6-hydroxyhexanoic acid
InChIKey: IWHLYPDWHHPVAA-UHFFFAOYSA-N
SMILES: O=C(CCCCCO)O
Biological Activity: 6-Hydroxyhexanoic acid (6-HHA) is a bacterial effector molecule with metabolic and immunomodulatory activities. 6-Hydroxyhexanoic acid activates the JAK1-STAT1 signaling pathway, promotes phenotypic conversion of M2 macrophages to M1 macrophages, and exerts anti-tumor effects by regulating macrophage polarization. 6-Hydroxyhexanoic acid inhibits lipolysis in adipocytes mediated by Gαi family GPCR, and reduces high-fat diet-induced weight gain and obesity. 6-Hydroxyhexanoic acid can be used in studies related to pancreatic ductal adenocarcinoma, obesity, and insulin resistance[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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6-Hydroxyhexanoic acid | 99.14% | 6-Hydroxyhexanoic acid (6-HHA) is a bacterial effector molecule with metabolic and immunomodulatory activities. 6-Hydroxyhexanoic acid activates the JAK1-STAT1 signaling pathway, promotes phenotypic conversion of M2 macrophages to M1 macrophages, and exerts anti-tumor effects by regulating macrophage polarization. 6-Hydroxyhexanoic acid inhibits lipolysis in adipocytes mediated by Gαi family GPCR, and reduces high-fat diet-induced weight gain and obesity. 6-Hydroxyhexanoic acid can be used in studies related to pancreatic ductal adenocarcinoma, obesity, and insulin resistance. | ||||||||||||||||||||
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References
- [1]. Zhong Y, et al. Intratumoral microbiota-driven macrophage reprogramming in pancreatic cancer via Blautia metabolite 6-hydroxyhexanoic acid. International immunopharmacology. 2025 Oct 30;164:115421. [Content Brief]
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[2]. Sebag SC, et al. A medium chain fatty acid, 6-hydroxyhexanoic acid (6-HHA), protects against obesity and insulin resistance. Acta Pharm Sin B. 2024 Apr;14(4):1892-1894.
[Content Brief]
