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Cat. No.: HY-184445

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Antibacterial agent 355

Antibacterial agent 355 is a bacterial tRNA (m¹G37) methyltransferase (TrmD) inhibitor with an IC₅₀ of 0.85 μM against E. coli. Antibacterial agent 355 shows weak inhibitory activity against human Trm5, with an approximate IC₅₀ of 1.88 mM. Antibacterial agent 355 inhibits the growth of bacterial strains expressing TrmD. Antibacterial agent 355 can be used for the research of bacterial infections.

For research use only. We do not sell to patients.

Formula: C₂₈H₃₀N₄O₃
Molecular Weight:470.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Antibacterial agent 355 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Bacterial Infection

Antibacterial agent 355 (100 μM; 0-8 h) selectively inhibits growth of hyper-permeable bacteria expressing E. coli TrmD, with rapid, near-complete inhibition by 2 h at 100 μM, while showing weaker, slower inhibition of bacteria expressing human Trm5^[1].
Antibacterial agent 355 (16 h) inhibits growth of the hyper-permeable E. coli porin mutant strain with an MIC of 167 μM after 16 h of incubation at 37 °C^[1].
Antibacterial agent 355 (Compound 16) (100 μM; 2.5 h) inhibits growth of the hyper-permeable E. coli porin mutant strain by 99.3% at a concentration of 100 μM after 2.5 h of incubation at 37 °C^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

Chemical Information

Molecular Weight 470.56
Formula C₂₈H₃₀N₄O₃
SMILES

O=C(N)C(C=C1)=CN=C1NCC(C)(C)C2=CC(CNC(/C=C/C(C3=CC=C(C)C=C3)=O)=O)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Masuda, I., et al. (2026). Nicotinamide-Based Covalent Inhibitors of tRNA (m1G37) Methyltransferase (TrmD) to Increase Antibacterial Activity. ACS Medicinal Chemistry Letters.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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