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nonsense

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Apoptosis (2) Autophagy (3) Bcl-2 Family (2) Biochemical Assay Reagents (1) CaMK (1) CFTR (4) DNA Methyltransferase (1) DNA/RNA Synthesis (5) Drug Derivative (3) Dystrophin (1) Eukaryotic Initiation Factor (eIF) (4) Huntingtin (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Molecular Glues (1) P-glycoprotein (1) Reference Standards (4) Ser/Thr Kinase (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (1) Inflammation/Immunology (5) Metabolic Disease (8) Neurological Disease (4)
Oligonucleotides:	Antisense Oligonucleotides (1)

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Peptides

Natural
Products

Isotope-Labeled Compounds

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111374

NMDI14 Maximum Cited Publications 16 Publications Verification	DNA/RNA Synthesis	Cancer
NMDI14 is a nonsense mediated RNA decay (NMD) inhibitor. NMDI14 disrupts the SMG7-UPF1 interactions and inhibits NMD.

HY-114231B

Exaluren disulfate 2 Publications Verification ELX-02 disulfate; NB-124 disulfate	DNA/RNA Synthesis	Inflammation/Immunology
Exaluren (ELX-02; NB-124) disulfate is an synthetic eukaryotic ribosome-selective glycoside that induces read-through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren disulfate is used for the research of cystic fibrosis caused by nonsense mutations .

HY-159641

VVD-130037 BAY-3605349	Molecular Glues Keap1-Nrf2	Metabolic Disease Inflammation/Immunology Cancer
VVD-130037 (BAY-3605349) is a covalent molecular glue and allosteric NRF2 degrader. VVD-130037 covalently binds to KEAP1 and allosterically enhances the affinity of KEAP1-CUL3, promotes the formation of the active KEAP1-CUL3 E3 ligase complex, and thereby enhances the ubiquitination and degradation of NRF2. VVD-130037 exhibits KEAP1 target-binding activity both in in vitro systems and mouse models, and it can be used in research related to NRF2-dependent cancers, solid tumors harboring KEAP1 nonsense mutations and frameshift mutations, as well as advanced solid tumors .

HY-161111

KVS0001	Ser/Thr Kinase	Cancer
KVS0001 is a selective SMG1 inhibitor. KVS0001 elevates the expression of transcripts and proteins resulting from truncating mutations. KVS0001 increased the presentation of immune-targetable HLA class I-associated peptides from nonsense-mediated decay (NMD)-downregulated proteins on the surface of cancer cells. KVS0001 exerts anti-tumor properties and can be studied in research for NMD-related diseases, including cancer and inherited diseases .

HY-101513

eIF4A3-IN-1 4 Publications Verification	Eukaryotic Initiation Factor (eIF)	Neurological Disease Cancer
eIF4A3-IN-1 is a selective eIF4A3 inhibitor (IC₅₀: 0.26 μM; K_d: 0.043 μM) with cellular nonsense-mediated RNA decay (NMD) inhibitory activity. eIF4A3-IN-1 can specifically bind to the non-ATP binding site of eIF4A3. eIF4A3-IN-1 has anti-tumor and analgesic activities .

HY-14832

Ataluren 5+ Cited Publications PTC124	CFTR Autophagy	Metabolic Disease Cancer
Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.

HY-118341

Clitocine	Apoptosis Bcl-2 Family	Cancer
Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity .

HY-114231

Exaluren 2 Publications Verification ELX-02; NB-124	Drug Derivative	Inflammation/Immunology
Exaluren (ELX-02; NB-124) is an synthetic eukaryotic ribosome-selective glycoside that induces read-through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren is used for the research of cystic fibrosis caused by nonsense mutations .

HY-150089

SRI-37240	CFTR	Inflammation/Immunology
SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418 .

HY-W009912

H-Tyr(Me)-OH	Amino Acid Derivatives	Others
H-Tyr(Me)-OH is a synthetic amino acid, and can enter into protein in E. coli in response to an amber nonsense codon .

HY-14832R

Ataluren (Standard) 1 Publications Verification PTC124 (Standard)	Reference Standards CFTR Autophagy	Metabolic Disease Cancer
Ataluren (Standard) is the analytical standard of Ataluren. This product is intended for research and analytical applications. Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.

HY-143792

HTT-D3	Huntingtin P-glycoprotein	Neurological Disease
HTT-D3 is an orally active, blood-brain barrier penetrant splicing modulator of huntingtin (HTT). HTT-D3 promotes the inclusion of a pseudo-exon containing a premature termination codon into HTT pre-mRNA, triggers nonsense-mediated mRNA degradation and reduces HTT protein levels. HTT-D3 induces dose-dependent, comparable reductions in mutant HTT protein in both the brain and peripheral tissues of transgenic mouse models. HTT-D3 can be used for the research of Huntington's disease .

HY-101203

GJ103	Drug Derivative	Metabolic Disease Cancer
GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations .

HY-101203A

GJ103 sodium 1 Publications Verification	DNA/RNA Synthesis	Metabolic Disease Cancer
GJ103 sodium is a read-through compound that can induce read through of premature stop codons. GJ103 sodium has potential for the research of genetic disorders caused by nonsense mutations .

HY-P10638A

TAT-CN21 (scrambled)	CaMK	Cardiovascular Disease Neurological Disease
TAT-CN21 (scrambled) is a nonsense sequence control peptide fused with the TAT cell-penetrating sequence. It exerts no inhibitory effect on CaMKII activity and serves as a negative control for TatCN21 (HY-P10638) .

HY-177569

NVS1.1	Eukaryotic Initiation Factor (eIF)	Others
NVS1.1 is a potent, orally active and brain-penetrant readthrough promoter. NVS1.1 triggers the degradation of eRF1 by activating the ribosome-related quality control pathways (involving GCN1, RNF14, and RNF25), thereby facilitating the reading through of premature termination codons. NVS1.1 can be used for the research of genetic diseases caused by nonsense mutations .

HY-123359

RTC14	DNA/RNA Synthesis Dystrophin	Others
RTC14 is a read-through compound (RTC) that can induce ribosomes to bypass nonsense mutations in mRNA and allow the production of full-length functional proteins. RTC14 has the potential to be used in the research of various genetic disorders, such as nonsense mutations in the ataxia-telangiectasia mutated (ATM) gene and the dystrophin gene .

HY-177963

NV914	DNA Methyltransferase	Inflammation/Immunology
NV914 is an inhibitor of FTSJ1 (tryptophan tRNA-specific 2'-O-methyltransferase) that inhibits the methyltransferase activity of FTSJ1, induces translational readthrough of premature termination codons, and enables genes carrying nonsense mutations to synthesize full-length proteins. NV914 belongs to translational readthrough-inducing compounds (TRIDs). NV914 exhibits translational readthrough activity against nonsense mutations in in vitro systems, does not induce readthrough of natural termination codons, and restores CFTR protein expression. NV914 shows favorable acute oral tolerance in mice, with low health risks and good safety profiles. NV914 is applicable to research related to cystic fibrosis and Shwachman-Diamond syndrome .

HY-177757

NVS2.1	Eukaryotic Initiation Factor (eIF)	Others
NVS2.1 is a potent, orally active and brain-penetrant readthrough promoter. NVS2.1 triggers the degradation of eRF1 by activating the ribosome-related quality control pathways (involving GCN1, RNF14, and RNF25), thereby facilitating the reading through of premature termination codons. NVS2.1 can be used for the research of genetic diseases caused by nonsense mutations .

HY-114231C

Exaluren sulfate ELX-02 sulfate; NB-124 sulfate	Drug Derivative	Metabolic Disease
Exaluren (ELX-02; NB-124) sulfate is an synthetic eukaryotic ribosome-selective glycoside that induces read-through of nonsense mutations, resulting in normally localized full-length functional proteins. Exaluren sulfate is used for the research of cystic fibrosis caused by nonsense mutations .

HY-126210

GJ072	Biochemical Assay Reagents	Others
GJ072 is a read-through compound (RTCs). GJ072 can induce “readthrough” .

HY-14832S1

Ataluren-13C6 PTC124-¹³C₆	Isotope-Labeled Compounds Autophagy CFTR	Metabolic Disease Cancer
Ataluren- ¹³C₆ (PTC124- ¹³C₆) is ¹³C labeled Ataluren. Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.

HY-157468

(R)-ELX-02	Others	Others
(R)-ELX-02, also referred to as NB-124, is an eukaryotic ribosomal selective glycoside (ERSG) engineered to enhance read-through activity in patients with nonsense mutations, facilitating the generation of adequate levels of full-length functional protein.

HY-118341R

Clitocine (Standard)	Reference Standards Apoptosis Bcl-2 Family	Cancer
H-Chpro-OH.HCl (Standard) is the analytical standard of H-Chpro-OH.HCl. This product is intended for research and analytical applications. H-Chpro-OH.HCl is a proline derivative .

HY-101203AR

GJ103 sodium (Standard)	DNA/RNA Synthesis Reference Standards	Metabolic Disease Cancer
GJ103 (sodium) (Standard) is the analytical standard of GJ103 (sodium) (HY-101203A). This product is intended for research and analytical applications. GJ103 sodium is a read-through compound that can induce read through of premature stop codons. GJ103 sodium has potential for the research of genetic disorders caused by nonsense mutations .

HY-101513R

eIF4A3-IN-1 (Standard)	Eukaryotic Initiation Factor (eIF) Reference Standards	Neurological Disease Cancer
eIF4A3-IN-1 (Standard) is the analytical standard of eIF4A3-IN-1 (HY-101513). This product is intended for research and analytical applications. eIF4A3-IN-1 is a selective eIF4A3 inhibitor (IC50: 0.26 μM; Kd: 0.043 μM) with cellular nonsense-mediated RNA decay (NMD) inhibitory activity. eIF4A3-IN-1 can specifically bind to the non-ATP binding site of eIF4A3. eIF4A3-IN-1 has anti-tumor and analgesic activities .

Cat. No.	Product Name	Target	Research Area

HY-W009912

H-Tyr(Me)-OH	Amino Acid Derivatives	Others
H-Tyr(Me)-OH is a synthetic amino acid, and can enter into protein in E. coli in response to an amber nonsense codon .

HY-P10638A

TAT-CN21 (scrambled)	CaMK	Cardiovascular Disease Neurological Disease
TAT-CN21 (scrambled) is a nonsense sequence control peptide fused with the TAT cell-penetrating sequence. It exerts no inhibitory effect on CaMKII activity and serves as a negative control for TatCN21 (HY-P10638) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-118341

Clitocine	Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification Cancer	Apoptosis Bcl-2 Family
Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity .

HY-118341R

Clitocine (Standard)	Alkaloids Structural Classification Microorganisms Other Alkaloids Source Classification	Reference Standards Apoptosis Bcl-2 Family
H-Chpro-OH.HCl (Standard) is the analytical standard of H-Chpro-OH.HCl. This product is intended for research and analytical applications. H-Chpro-OH.HCl is a proline derivative .

Cat. No.	Product Name	Chemical Structure

HY-14832S1

Ataluren-13C6
Ataluren- ¹³C₆ (PTC124- ¹³C₆) is ¹³C labeled Ataluren. Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.

Host:	Rabbit (2)
Reactivity:	Human (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) IP (2) IHC-F (2) WB (2) FC (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82113

	RENT1 Antibody (YA1858) UPF1; KIAA0221; RENT1; Regulator of nonsense transcripts 1; ATP-dependent helicase RENT1; nonsense mRNA reducing factor 1; NORF1; Up-frameshift suppressor 1 homolog; hUpf1	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse
	RENT1 Antibody (YA1858) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RENT1.

HY-P82113A

	RENT1 Antibody (YA1858)(PBS only) UPF1; KIAA0221; RENT1; Regulator of nonsense transcripts 1; ATP-dependent helicase RENT1; nonsense mRNA reducing factor 1; NORF1; Up-frameshift suppressor 1 homolog; hUpf1	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse
	RENT1 Antibody (YA1858) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RENT1.

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Cat. No.	Product Name		Classification

HY-158830

MDM4-targeting ASO sodium		Antisense Oligonucleotides
MDM4-targeting ASO sodium is a 25mer antisense oligonucleotide targeting MDM4. MDM4-targeting ASO sodium induced exon 6 skipping, leading to nonsense-mediated decay of the mRNA transcript that excludes exon-6. In multiple human melanoma cell lines and in melanoma patient-derived xenograft (PDX) mouse models, MDM4-targeting ASO-mediated skipping of exon 6 decreased MDM4 abundance, inhibited melanoma growth, and enhanced sensitivity to MAPK-targeting therapeutics.

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nonsense

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
Products