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Results for "

oxindole

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) AMPK (1) Autophagy (2) Bacterial (2) Biochemical Assay Reagents (2) CDK (2) Dopamine Transporter (1) Endogenous Metabolite (2) GHSR (1) HIV (2) Isotope-Labeled Compounds (2) Ligands for E3 Ligase (1) mAChR (2) Phosphodiesterase (PDE) (1) Reference Standards (4) Src (1) VEGFR (4)
By Research Areas:	Cancer (10) Cardiovascular Disease (1) Endocrinology (2) Infection (2) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (8)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0061

*Oxindole* 3 Publications Verification 2-Indolinone	HIV Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.

HY-59227

6-Bromooxindole 6-Bromo-2-oxindole	Biochemical Assay Reagents	Others
6-Bromo-2-oxindole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-N0901

Corynoxine 3 Publications Verification	Autophagy	Neurological Disease Cancer
Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .

HY-N4157

Isopteropodine	mAChR 5-HT Receptor Bacterial	Neurological Disease
Isopteropodine is a positive modulator that selectively acts on muscarinic M₁ and 5-HT₂ receptors. Isopteropodine has an EC₅₀ of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research .

HY-W009666

6-Chloro-5-(2-chloroethyl)oxindole	Dopamine Transporter	Others
6-Chloro-5-(2-chloroethyl)oxindole (Imp Z2) is an impurity of Ziprasidone (HY-14542), a substrate of the human dopamine transporter (hDAT) .

HY-116959

SM-130686	GHSR	Metabolic Disease
SM-130686 is an oxindole derivative and an active GH secretagogue (GHS). SM-130686 stimulates GH release with a Half-maximum stimulation of 6.3 nM. SM-130686 has an orally active .

HY-N4156

Pteropodine	Others	Others
Pteropodine (compound 3) is a monoterpenoid oxindole alkaloid that can be isolated from Hamelia patens. Pteropodine modulates the functions of M1 muscarinic and 5-HT2 receptors. Pteropodine has antioxidant and antimutagenic properties .

HY-120720

Isomitraphylline	Others	Cancer
Isomitraphylline, an oxindole alkaloid, has potent anti-cancer activity .

HY-N9163

Uncarine A	Others	Others
Uncarine A is a oxindole alkaloid, which can be isolated from Ulzcaria berlzaysii F. Muell .

HY-N16467

Uncarine F Speciofiline	Others	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Uncarine F (Speciofiline) is a pentacyclic oxindole alkaloid found in Uncaria tomentosa. Uncaria alkaloids have wide medicinal properties, including neuroprotective, anticancer, and antihypertensive activities. Uncaria alkaloids may stimulate the immune system, relax smooth muscles, dilate blood vessels, and act as a diuretic. Uncarine F can be used for the researches of cancer, immunology, cardiovascular and neurological disease .

HY-W746828

Oxindole-3-acetic acid-13C6	Isotope-Labeled Compounds	Others
Oxindole-3-acetic acid- ¹³C₆ is ¹³C labeled Oxindole-3-acetic acid .

HY-108444

(Z)-FeCP-oxindole	VEGFR	Cancer
(Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC₅₀ value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC₅₀ less than 1 μM .

HY-108444A

(E)-FeCP-oxindole	VEGFR	Cancer
(Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC₅₀ value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC₅₀ less than 1 μM .

HY-Y0061R

Oxindole (Standard) 2-Indolinone (Standard)	Reference Standards HIV Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Oxindole (Standard) is the analytical standard of Oxindole. This product is intended for research and analytical applications. Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.

HY-117034

Rankinidine	Others	Others
Rankinidine is an oxindole alkaloid that is isolated from the MeOH extract of the stem of Gelsemium rankinii .

HY-N0901B

Corynoxine hydrochloride	Autophagy	Neurological Disease Cancer
Corynoxine hydrochloride, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria macrophylla. Corynoxine hydrochloride is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .

HY-115943

Anticancer agent 30	CDK	Cancer
Anticancer agent 30 (compound 6f-Z), a 3-arylidene-2-oxindole derivative, is a selective CDK2 inhibitor with potent anticancer activity .

HY-169359

L321	Ligands for E3 Ligase	Others
4-Methylphenoxyacetic acid-Oxindole-CF3 is the E3 ligase ligand part of L134 (HY-169358). 4-Methylphenoxyacetic acid-Oxindole-CF3 can be utilized in PROTAC synthesis .

HY-114023

BML-288	Phosphodiesterase (PDE)	Neurological Disease
BML-288 (compound Oxindole 1) is a potent PDE2 inhibitor with an IC₅₀ value of 40 nM. BML-288 has the potential for the research of osteoarthritis pain .

HY-N4157R

Isopteropodine (Standard)	Reference Standards mAChR 5-HT Receptor Bacterial	Neurological Disease
Isopteropodine (Standard) is the analytical standard of Isopteropodine (HY-N4157). This product is intended for research and analytical applications. Isopteropodine is a positive modulator that selectively acts on muscarinic M₁ and 5-HT₂ receptors. Isopteropodine has an EC₅₀ of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research .

HY-153556

GW297361	CDK VEGFR Src	Others
GW297361 is an oxindole CDK inhibitor that elicits a Pho85-selective response in cells. GW297361 inhibits yeast Cdk1 and Pho85 with IC₅₀s of 20 nM and 400 nM in vitro, respectively .

HY-Z0036R

*N-Acetyl-2-oxindole* (Standard)**	Reference Standards
N-Acetyl-2-oxindole (Standard) is the analytical standard of N-Acetyl-2-oxindole. This product is intended for research and analytical applications.

HY-108444R

*(Z)-FeCP-oxindole* (Standard)**	Reference Standards VEGFR	Cancer
(Z)-FeCP-oxindole (Standard) is the analytical standard of (Z)-FeCP-oxindole (HY-108444). This product is intended for research and analytical applications. (Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC₅₀ value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC₅₀ less than 1 μM .

HY-Y0061S

Oxindole-d4 2-Indolinone-d₄	Isotope-Labeled Compounds	Others
Oxindole-d₄ (2-Indolinone-d₄) is the deuterium labeled Oxindole (HY-Y0061). Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.

HY-186155

AMPK activator 19	AMPK	Metabolic Disease
AMPK activator 19 (Compound 57), alkene oxindole derivative, is an AMPK activator. AMPK activator 19 can be used for the research of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes .

HY-P4948

Coumarin-Phalloidin	Biochemical Assay Reagents	Others
Coumarin-phalloidin is a kind of phalloidin labeled with Coumarin (HY-N0709). Coumarin-phalloidin is a new type of actin probe that can be used for triple immunofluorescence microscopic observation of the cell skeleton .

6-Bromooxindole 6-Bromo-2-oxindole	Biochemical Assay Reagents
6-Bromo-2-oxindole is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Target	Research Area

HY-P4948

Coumarin-Phalloidin	Biochemical Assay Reagents	Others
Coumarin-phalloidin is a kind of phalloidin labeled with Coumarin (HY-N0709). Coumarin-phalloidin is a new type of actin probe that can be used for triple immunofluorescence microscopic observation of the cell skeleton .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0061

*Oxindole* 3 Publications Verification 2-Indolinone	Neurological Disease Classification of Application Fields Metabolic Disease Plants Endogenous metabolite Indole Alkaloids Infection Alkaloids Human Gut Microbiota Metabolites other families Disease Research Fields Endocrinology Source Classification	HIV Endogenous Metabolite
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.

HY-N0901

Corynoxine 3 Publications Verification	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids Source Classification	Autophagy
Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .

HY-N4157

Isopteropodine	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Structural Classification Iridoids Terpenoids Rubiaceae Plants Source Classification	mAChR 5-HT Receptor Bacterial
Isopteropodine is a positive modulator that selectively acts on muscarinic M₁ and 5-HT₂ receptors. Isopteropodine has an EC₅₀ of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research .

HY-N4156

Pteropodine	Alkaloids Other Alkaloids Rubiaceae Plants Hamelia patens Jacq. Source Classification	Others
Pteropodine (compound 3) is a monoterpenoid oxindole alkaloid that can be isolated from Hamelia patens. Pteropodine modulates the functions of M1 muscarinic and 5-HT2 receptors. Pteropodine has antioxidant and antimutagenic properties .

HY-120720

Isomitraphylline	Alkaloids Pyrrole Alkaloids Classification of Application Fields Uncaria hirsutaHavil. Rubiaceae Plants Disease Research Fields Cancer Source Classification	Others
Isomitraphylline, an oxindole alkaloid, has potent anti-cancer activity .

HY-N9163

Uncarine A	Alkaloids Other Alkaloids Uncaria hirsutaHavil. Rubiaceae Plants Source Classification	Others
Uncarine A is a oxindole alkaloid, which can be isolated from Ulzcaria berlzaysii F. Muell .

HY-N16467

Uncarine F Speciofiline	Structural Classification Alkaloids Oxindole Alkaloids Rubiaceae Plants Mitragyna parvifolia (Roxb.) Korth. Source Classification	Others
Uncarine F (Speciofiline) is a pentacyclic oxindole alkaloid found in Uncaria tomentosa. Uncaria alkaloids have wide medicinal properties, including neuroprotective, anticancer, and antihypertensive activities. Uncaria alkaloids may stimulate the immune system, relax smooth muscles, dilate blood vessels, and act as a diuretic. Uncarine F can be used for the researches of cancer, immunology, cardiovascular and neurological disease .

HY-Y0061R

Oxindole (Standard) 2-Indolinone (Standard)	Alkaloids Structural Classification Human Gut Microbiota Metabolites other families Plants Endogenous metabolite Indole Alkaloids Source Classification	Reference Standards HIV Endogenous Metabolite
Oxindole (Standard) is the analytical standard of Oxindole. This product is intended for research and analytical applications. Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.

HY-117034

Rankinidine	Alkaloids Classification of Application Fields Other Diseases Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids Source Classification	Others
Rankinidine is an oxindole alkaloid that is isolated from the MeOH extract of the stem of Gelsemium rankinii .

HY-N0901B

Corynoxine hydrochloride	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids Source Classification	Autophagy
Corynoxine hydrochloride, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria macrophylla. Corynoxine hydrochloride is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .

HY-N4157R

Isopteropodine (Standard)	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Structural Classification Iridoids Terpenoids Rubiaceae Plants Source Classification	Reference Standards mAChR 5-HT Receptor Bacterial
Isopteropodine (Standard) is the analytical standard of Isopteropodine (HY-N4157). This product is intended for research and analytical applications. Isopteropodine is a positive modulator that selectively acts on muscarinic M₁ and 5-HT₂ receptors. Isopteropodine has an EC₅₀ of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research .

Cat. No.	Product Name	Chemical Structure

HY-W746828

Oxindole-3-acetic acid-13C6
Oxindole-3-acetic acid- ¹³C₆ is ¹³C labeled Oxindole-3-acetic acid .

HY-Y0061S

Oxindole-d4
Oxindole-d₄ (2-Indolinone-d₄) is the deuterium labeled Oxindole (HY-Y0061). Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.

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oxindole

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
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