851681-89-5
851681-89-5
Chemical Structure
BML-288
- CAS No.: 851681-89-5
- Formula:C14H10N4O3S
- Molecular Weight:314.32
IUPAC Name: 5-methyl-6-oxo-N-(1,3,4-thiadiazol-2-yl)-6,7-dihydro-5H-furo[2,3-f]indole-7-carboxamide
InChIKey: OQMLSKSSPKAKJQ-UHFFFAOYSA-N
SMILES: O=C(C1C(N(C)C2=C1C=C(OC=C3)C3=C2)=O)NC4=NN=CS4
Biological Activity: BML-288 (compound Oxindole 1) is a potent PDE2 inhibitor with an IC50 value of 40 nM. BML-288 has the potential for the research of osteoarthritis pain[1].
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BML-288 | BML-288 (compound Oxindole 1) is a potent PDE2 inhibitor with an IC50 value of 40 nM. BML-288 has the potential for the research of osteoarthritis pain. | |||||||||||||||||||||
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References
- [1]. Plummer MS, et al. Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3438-42. [Content Brief]
Keywords
