59-48-3
59-48-3
Chemical Structure
Oxindole
Synonym(s): 2-Indolinone
- CAS No.: 59-48-3
- Formula:C8H7NO
- Molecular Weight:133.15
IUPAC Name: indolin-2-one
InChIKey: JYGFTBXVXVMTGB-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C=CC=C2)C1
Biological Activity: Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Oxindole | 99.77% | Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors. | ||||||||||||||||||||
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Oxindole (Standard) | ≥98% | Oxindole (Standard) is the analytical standard of Oxindole. This product is intended for research and analytical applications. Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors. | ||||||||||||||||||||
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Oxindole-d4 | Oxindole-d4 (2-Indolinone-d4) is the deuterium labeled Oxindole (HY-Y0061). Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors. | |||||||||||||||||||||
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6-Bromooxindole | 98.12% | 6-Bromo-2-oxindole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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5-Iodoindolin-2-one | 99.25% | 5-Iodoindolin-2-one (5-iodo-2,3-dihydro-1H-indol-2-one) is an intermediate that can be used in the synthesis of degraders, such as KRAS degrader-1 (HY-153880). | ||||||||||||||||||||
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5-Hydroxyoxindole | 95.09% | 5-Hydroxyoxindole is a structural analog of uric acid for its antioxidant. 5-Hydroxyoxindole has DPPH radical scavenging activities and lipid peroxidation-inhibitory activities. 5-Hydroxyoxindole is a product of partial metabolism of tryptophan involving conversion in the gut lumen of tryptophan to indole through the action of bacterial tryptophanase and tryptophan synthase. 5-Hydroxyoxindole is one of the main molecules responsible for the neurological symptoms of hepatic encephalopathy in rats. 5-Hydroxyoxindole can be used for the research of oxidative stress-mediated disorders. | ||||||||||||||||||||
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3,4-Dihydroquinolin-2(1H)-one | 3,4-Dihydroquinolin-2(1H)-one is a building block, that can be used for synthesis of antipsychotic agent, such as Aripiprazole (HY-14546) or CYP11B2 inhibitors. | |||||||||||||||||||||
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5-Bromoindolin-2-one | 99.50% | 5-Bromoindolin-2-one (5-Bromooxindole) is a synthetic intermediate. 5-Bromoindolin-2-one can be used for the synthesis of CDK2 inhibitors and antibacterial agents. | ||||||||||||||||||||
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5-Fluoro-2-oxoindoline | 99.91% | 5-Fluoro-2-oxoindoline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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3-Methylindolin-2-one | 98.89% | 3-Methylindolin-2-one is an endogenous metabolite. | ||||||||||||||||||||
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Isatin (Standard) | ≥98% | Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM). Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity. Shows effect on the serotonergic system. | ||||||||||||||||||||
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6-Chlorooxindole | 99.31% | 6-Chlorooxindole (compound 2) is a selective chymase inhibitor with an IC50 of 470 μM. 6-Chlorooxindole shows >100-fold selectivity for chymase over cathepsin G. 6-Chlorooxindole can be used for the study of cardiovascular disease. | ||||||||||||||||||||
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Indoline (Standard) | ≥98% | Indoline (Standard) is an analytical standard for Indoline (HY-Y0788). This product is intended for research and analytical applications. Indoline is a HIV-1 envelope glycoprotein gp120 binder. Indoline binds to the conserved CD4-binding site of gp120 (the Phe 43 cavity and its surrounding vestibule), competitively blocks the binding of CD4, and prematurely triggers conformational changes of the Env trimer, resulting in viral inactivation. Indoline induces the conformational opening of HIV-1 Env on infected cells, exposes vulnerable epitopes, increases antibody recognition rate, enhances the binding of FcγRIIIa receptors, and sensitizes infected cells to antibody-dependent cellular cytotoxicity. Indoline is a derivative of Indole (HY-W001132). Indoline can be used in studies related to HIV-1 infection. | ||||||||||||||||||||
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