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pH 6.0

" in MedChemExpress (MCE) Product Catalog:

22

Inhibitors & Agonists

4

Fluorescent Dyes

11

Biochemical Assay Reagents

1

Inhibitory Antibodies

1

Natural
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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0861
    EGTA
    Maximum Cited Publications
    25 Publications Verification

    		 Biochemical Assay Reagents Inflammation/Immunology
    EGTA is a cell-impermeant specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages .
    EGTA
  • HY-B1610L
    Sodium Citrate Buffer, 0.5M, pH 6.0
    1 Publications Verification

    		 Biochemical Assay Reagents Others
    Sodium citrate buffer, 0.5M, pH 6.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.0 is used for RNA isolation and antigens detection in fixed tissue .
    Sodium Citrate Buffer, 0.5M, pH 6.0
  • HY-P99965
    Crovalimab

    SKY59; RO7112689; RG-6107

    		 Complement System Cardiovascular Disease Metabolic Disease
    Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research .
    Crovalimab
  • HY-101882
    BCECF
    3 Publications Verification

    2′,7′-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein

    		 Fluorescent Dye Others
    BCECF is a cell-impermeant pH-sensitive fluorescent dye. BCECF allows measurements in the physiological pH range 6.0-8.0. Excitation ratio: 490/440 nm; Emission intensity: 535 nm.
    BCECF
  • HY-101883A
    BCECF Acetoxymethyl ester
    5+ Cited Publications

    		 Fluorescent Dye Others
    BCECF Acetoxymethyl ester is a cell membrane permeable compound widely-used as a fluorescent indicator for intracellular pH. BCECF Acetoxymethyl ester could diffuse through the cell membrane and intracellular esterase cleave the ester bond releasing BCECF (HY-101882). BCECF allows measurements in the physiological pH range 6.0-8.0. Excitation ratio: 490/440 nm; Emission intensity: 535 nm .
    BCECF Acetoxymethyl ester
  • HY-D0861A
    EGTA tetrasodium
    Maximum Cited Publications
    25 Publications Verification

    		 Biochemical Assay Reagents Inflammation/Immunology
    EGTA tetrasodium is a cell-impermeant specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages .
    EGTA tetrasodium
  • HY-128545
    Nitrazine yellow

    Nitrazine paper; pHenapHthazine

    		 Biochemical Assay Reagents Others
    Nitrazine yellow (Nitrazine paper; Phenaphthazine) is a pH indicator. The color of Nitrazine yellow changes from yellow to blue in the pH range from 6.0 to 7.0. Nitrazine yellow is a kind of biological materials or organic compounds that are widely used in life science research .
    Nitrazine yellow
  • HY-Y1422E
    Lipase,Aspergillusniger (Immobilized)

    		Biochemical Assay Reagents Lipase Others
    Lipase, Aspergillus niger (Immobilized) is an immobilized triacylglycerol acyl hydrolase and biocatalyst. Lipase, Aspergillus niger (Immobilized) broadly catalyzes the hydrolysis of glycerol-long-chain fatty acid esters, exhibits positional selectivity for the 1,3-positions of glycerol, but shows low hydrolysis efficiency for castor oil. Lipase, Aspergillus niger (Immobilized) displays optimal activity at 45°C and pH 7.0, and remains stable at temperatures up to 60°C and over a broad pH range of 2.0-9.0. Lipase, Aspergillus niger (Immobilized) is activated by Ca 2+ and Mg 2+, but inhibited by Mn 2+, Fe 2+ and Zn 2+ .
    Lipase,Aspergillusniger (Immobilized)
  • HY-160113A
    Sodium phosphate buffer 0.1M, pH 6.0

    		Biochemical Assay Reagents Others
    Sodium phosphate buffer 0.1M, pH 6.0 is mainly composed of two phosphates, Na2HPO4 and NaH2PO4, with a total phosphate concentration of 0.1 M, which mainly acts as a buffer in the reaction.
    Sodium phosphate buffer 0.1M, pH 6.0
  • HY-179665A
    0.1M Acetate Buffer, pH 6.0

    		Biochemical Assay Reagents Others
    0.1M Acetate Buffer, pH 6.0 is an acetate buffer with a concentration of 0.1 M and a pH of 6.0.
    0.1M Acetate Buffer, pH 6.0
  • HY-D2324
    EE-Flipper 33

    		Fluorescent Dye Others
    EE-Flipper 33 is a Flipper probe designed to evaluate the mechanism of early endocytosis. EE-Flipper has a pKa value of 10.6 and is capable of tracking approximately 70% of early endosomes (EE) in live cells. Furthermore, EE-Flipper 33 can also label the Golgi apparatus in live cells with an internal pH ranging from 6.0 to 6.7 .
    EE-Flipper 33
  • HY-Y0699R
    Methyl red (Standard)

    		Fluorescent Dye Reference Standards Others
    Methyl red (Standard) is the analytical standard of Methyl red. This product is intended for research and analytical applications. Methyl red is an azo dye that acts as a pH indicator. Methyl red is red and yellow at pH 4.4 and 6.0 respectively .
    Methyl red (Standard)
  • HY-B1610Q
    Sodium Citrate Buffer, 0.01 M, pH 6.0

    		Biochemical Assay Reagents Others
    Sodium Citrate Buffer, 0.01 M, pH 6.0 is a commonly used buffer composed of citric acid and sodium citrate. Sodium Citrate Buffer, 0.01 M, pH 6.0 is widely used in?molecular biology, immunohistochemistry (IHC), and biochemistry
    Sodium Citrate Buffer, 0.01 M, pH 6.0
  • HY-W145108
    Methyl red hydrochloride

    		Biochemical Assay Reagents Others
    Methyl red hydrochloride is an azo dye that acts as a pH indicator. Methyl red is red and yellow at pH 4.4 and 6.0 respectively .
    Methyl red hydrochloride
  • HY-182606
    Citric acid-Sodium citrate powder (10 mM, pH 6.0)

    		Biochemical Assay Reagents Others
    Citric acid-Sodium citrate powder (10 mM, pH 6.0) is a pre-formulated powder made from citric acid and sodium citrate, which can be used to prepare antigen retrieval solutions in immunohistochemistry (IHC).
    Citric acid-Sodium citrate powder (10 mM, pH 6.0)
  • HY-123184
    S 1924

    		Proton Pump Neurological Disease Metabolic Disease
    S 1924 is a potent H+, K+-ATPase inhibitor, with IC50 values of 10.3 and 1.6 μM at pH 7.4 and pH 6.0, respectively .
    S 1924
  • HY-19153
    Nepaprazole

    rel-TY-11345 free base

    		 Proton Pump Inflammation/Immunology
    Nepaprazole (rel-TY-11345 free base) is a proton pump inhibitor. Nepaprazole inhibits H +/K +-ATPase activity in isolated rabbit gastric mucosal microsomes with the IC50 values of 5.8 μM and 9.9 μM at pH 6.0 and pH 7.4, respectively. Nepaprazole can be used for study of peptic ulcer diseases .
    Nepaprazole
  • HY-131586
    3,7-Dihydroxyflavone

    Resogalangin

    		 17β-HSD Estrogen Receptor/ERR Aldose Reductase Endocrinology Cancer
    3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC50=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm .
    3,7-Dihydroxyflavone
  • HY-179672
    7.5M LiCl,RNase-free

    		Biochemical Assay Reagents Others
    7.5M LiCl,RNase-free is a sterile, RNase- and DNase-free lithium chloride solution, commonly used for RNA precipitation. 7.5M LiCl,RNase-free can specifically precipitate RNA, effectively removing sugar, protein, and DNA contamination from RNA samples to obtain high-purity RNA samples. The pH of this solution is 5.5-6.0.
    7.5M LiCl,RNase-free
  • HY-E70569
    α-N-acetylgalactosidase

    		Biochemical Assay Reagents Others
    α-N-acetylgalactosidase (EC 3.2.1.4) is a highly specific exoglycosidase that efficiently hydrolyzes α-N-acetylgalactosamine (GalNAc) linked to serine or threonine residues in glycoproteins (Tn antigen). α-N-acetylgalactosidase shows activity against α 1-3 linked terminal GalNAc . α-N-acetylgalactosidase is suitable for use in the pH range of 6.0-7.6 and does not require cofactors or special buffer systems.
    α-N-acetylgalactosidase
  • HY-165459
    KJM429

    MK-056

    		 TRP Channel Infection Inflammation/Immunology
    KJM429 (MK-056) is a high-affinity ligand for the rat vanilloid receptor rTRPV1 (Ki=30-63 nM) with a unique dual regulatory function. KJM429 acts as a competitive antagonist to inhibit TRPV1 receptor activation induced by Capsaicin (HY-10448), resiniferatoxin, thermal stimulation and weak acid (pH 6.0), and switches to a TRPV1 agonist under strong acid conditions (pH<5.5). KJM429 effectively blocks calcium influx induced by Capsaicin and partial thermal stimulation, and triggers calcium uptake under low pH conditions, with minimal effects on non-TRPV1-mediated calcium signaling. KJM429 can be used for research on the mechanisms of pain-related diseases such as postherpetic neuralgia, diabetic neuropathy, cluster headache, osteoarthritis and pruritus .
    KJM429
  • HY-DY1098
    BCECF (solution)

    2′,7′-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein (solution)

    		 Fluorescent Dye Others
    BCECF (solution) (2′,7′-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein (solution)) is a cell-impermeant pH-sensitive fluorescent dye. BCECF allows measurements in the physiological pH range 6.0-8.0. Excitation ratio: 490/440 nm; Emission intensity: 535 nm.
    Solvent and concentration: DMSO: 10 mM
    BCECF (solution)

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