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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
pcsk9-in-28
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "pcsk9-in-28" in MCE Product Catalog:
Target:
Research Areas:
PCSK9-IN-23 (compound 5C) is a potent PCSK9 inhibitor. PCSK9-IN-23 blocks PCSK9 secretion from HepG2 cells, significantly increases LDL receptor (LDLR) expression .
Cat. No.: HY-159595
CAS No.: 1233353-86-0
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PCSK9-IN-29 is a lipid-lowering agent. PCSK9-IN-29 can increase low-density lipoprotein receptor (LDLR) protein expression and decrease PCSK9 protein expression in hepG2 cells. PCSK9-IN-29 can reduce the levels of serum LDL-C, TC, and liver enzyme ALT in crab eating macaques fed a high-fat diet, lower body weight and fat, and increase bone mineral content. PCSK9-IN-29 can be used for research on non-alcoholic fatty liver disease and obesity .
Cat. No.: HY-160036
CAS No.: 2794203-47-5
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PCSK9-IN-22 (compound 29) is an orally active inhibitor of PCSK9. PCSK9-IN-22 inhibits the interaction of the protein with LDLR in vivo .
Cat. No.: HY-161434
CAS No.: 3033361-09-7
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PCSK9-IN-26 (Compound 116) is an PCSK9 inhibitor (IC50 < 1 nM). PCSK9-IN-26 can be used for metabolic research .
Cat. No.: HY-161435
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PCSK9-IN-27 (Compound 108) is a PCSK9 inhibitor (IC50: 3.4 nM). PCSK9-IN-27 reduces LDLR degradation and increases LDL-C uptake .
Cat. No.: HY-153454
CAS No.: 2455425-15-5
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PCSK9-IN-18 (compound 188) is a potent PCSK9 inhibitor with a KD value of <200 nM .
Cat. No.: HY-155415
CAS No.: 2929219-77-0
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PCSK9-IN-20 (Compound 3i) is a PCSK9 inhibitor with an IC50 of 3.96 µM. PCSK9-IN-20 decreases PCSK9 and increases LDLR protein expression in vitro .
Cat. No.: HY-163141
CAS No.: 2974496-96-1
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PCSK9-IN-24 (Compound OY3) is a compound that targets PCSK9. PCSK9-IN-24 reduces PCSK9 levels and increases LDL uptake and may be used in atherosclerosis research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
