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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
peptide engineering
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "peptide engineering" in MCE Product Catalog:
9
9 Cited Publications
Synonyms: HOSu; 1-Hydroxy-2,5-pyrrolidinedione
Cat. No.: HY-P4198
CAS No.: 2375600-56-7
Synonyms: Fmoc-Sar10
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Cat. No.: HY-P5558
CAS No.: 917760-16-8
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Cat. No.: HY-P11328
CAS No.: 245120-10-9
Cat. No.: HY-P5284
CAS No.: 1613231-49-4
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Cat. No.: HY-P2263
CAS No.: 800379-47-9
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Cat. No.: HY-W835525
CAS No.: 216393-53-2
Cat. No.: HY-P4054
CAS No.: 1426415-02-2
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Cat. No.: HY-P11428
CAS No.: 2425606-55-7
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Cat. No.: HY-P5350
CAS No.: 809281-07-0
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Cat. No.: HY-164076
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mPEG-Epoxide is an activated polyethylene glycol (mPEG) derivative, which is achieved by converting the hydroxyl groups of mPEG into reactive epoxy groups. mPEG-Epoxide is a mild PEGylation reagent that reacts with amino groups in peptides and proteins to form stable secondary amine bonds. mPEG-Epoxide can be used in protein engineering and biomaterials research .
Cat. No.: HY-P2263A
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Cat. No.: HY-L937
931 compounds
Unnatural amino acids (UAAs), also referred to as non-canonical amino acids (ncAAs) or non-proteinogenic amino acids, are a class of amino acids that are distinct from the 20 standard natural amino acids. They can be obtained through chemical synthesis, biosynthesis, and other approaches, with structural diversity far exceeding that of natural amino acids. UAAs are mainly including naturally occurring non-canonical amino acids, chemically synthesized amino acids, and biosynthetic amino acids, which provide a molecular basis for protein function design.
UAAs exhibit significant value in multiple fields. They can optimize the pharmacokinetic properties of peptide drugs and peptidomimetics, modify enzyme functions and endow them with new biological activities, thereby overcoming the limitations of traditional peptide drugs and expanding the chemical space . Meanwhile, UAAs can serve as molecular probes to analyze protein-protein interactions and investigate the regulatory mechanisms of protein functions.
MCE has compiled a UAAs Fragment Library comprising nearly a thousand unnatural amino acid fragments with extensive coverage of chemical space and enhanced structural diversity. This compound library can be widely applied in peptide synthesis, drug design, and protein engineering.
Cat. No.: HY-L951
505 compounds
Macrocyclic scaffolds are increasingly valued in modern drug discovery for their exceptional activity against undruggable targets (proteases, kinases, PPIs). 2026 marks a key commercial breakthrough for oral macrocyclic peptides: enlicitide, the world’s first oral PCSK9 macrocyclic peptide, has received FDA approval. Macrocyclic candidates targeting KRAS and other classic undruggable targets have also entered clinical development, validating macrocyclization as an effective strategy to overcome druggability barriers.
Two core R&D directions lead current macrocyclic drug design: AI-driven de novo generation and structural optimization of small-molecule macrocycles, and macrocyclic peptides based on sequence design and conformational engineering. Macrocycle druggability hinges on embedded linkers, which determine cyclization efficiency, final conformation and drug-like properties. Bifunctional reaction orthogonality is the core linker selection criterion. Our linker library enables stepwise intramolecular cyclization with suppressed side reactions, accommodates varied ring sizes, and covers three key reaction systems: amide condensation, nucleophilic substitution and CuAAC click chemistry.
Built on classical macrocyclization systems, the library is processed through reaction classification, bifunctional orthogonality evaluation, novelty clustering and redundancy removal, with PROTAC long-chain and ADC cleavable linkers explicitly excluded. Featuring rigid, semi-rigid and flexible scaffolds, it is widely applicable to small-molecule macrocycle synthesis and linear peptide cyclization.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
