800379-47-9
Chemical Structure
KLD-12
- CAS 番号: 800379-47-9
- Formula:C68H122N16O19
- Molecular Weight:1467.79
InChIKey: JXVKXIMEQMJEAG-PEWBXTNBSA-N
SMILES: CC(C)C[C@@H](C(N)=O)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: KLD-12 is a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair[1][2][3].
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KLD-12 | 99.69% | KLD-12 is a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair. | ||||||||||||||||||||
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References
- [1]. Cao M, et al., Self-Assembled KLD-12/SDF-1 Polypeptide Promotes Differentiation and Migration of BMSCs via the Wnt/β-catenin Signaling Pathways. Protein Pept Lett. 2022;29(10):851-858. [Content Brief]
- [2]. Tripathi JK, et al., Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 2015 Jul;56:92-103. [Content Brief]
- [3]. Kisiday J, Jet al., Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9996-10001. [Content Brief]
