6066-82-6
Chemical Structure
N-Hydroxysuccinimide
Synonym(s): HOSu; 1-Hydroxy-2,5-pyrrolidinedione
- CAS No.: 6066-82-6
- Formula:C4H5NO3
- Molecular Weight:115.09
IUPAC Name: 1-hydroxypyrrolidine-2,5-dione
InChIKey: NQTADLQHYWFPDB-UHFFFAOYSA-N
SMILES: O=C(N1O)CCC1=O
Biological Activity: N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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N-Hydroxysuccinimide | 99.98% | N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering. | ||||||||||||||||||||
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References
- [1]. Zhang M, et al. Interactions of collagen molecules in the presence of N-hydroxysuccinimide activated adipic acid (NHS-AA) as a crosslinking agent. Int J Biol Macromol. 2011 Nov 1;49(4):847-54. [Content Brief]
- [2]. Ishikawa S, et al. N-Hydroxysuccinimide Bifunctionalized Triblock Cross-Linker Having Hydrolysis Property for a Biodegradable and Injectable Hydrogel System. ACS Biomater Sci Eng. 2019 Nov 11;5(11):5759-5769. [Content Brief]
- [3]. Klykov O, et al. Quantification of N-hydroxysuccinimide and N-hydroxysulfosuccinimide by hydrophilic interaction chromatography (HILIC)[J]. Analytical methods, 2015, 7(15): 6443-6448.
