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Results for "

photo-activatable

" in MedChemExpress (MCE) Product Catalog:

26

Inhibitors & Agonists

6

Fluorescent Dyes

1

Biochemical Assay Reagents

1

Natural
Products

5

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-133535
    PA Janelia Fluor® 646, SE
    1 Publications Verification

    PA-JF646-NHS

    		 Fluorescent Dye Others
    PA Janelia Fluor® 646, SE (PA-JF646-NHS) is a photo-activatable fluorescent dye. PA Janelia Fluor® 646, SE is a far-red light-excited, 405nm-activated NHS ester-based dye (λex/em = 650/664 nm). PA Janelia Fluor® 646, SE can achieve extremely low background and single-molecule-level ultra-high-resolution imaging through photo-controlled switching, making it a powerful tool for live cell super-resolution microscopy technology.
    PA Janelia Fluor® 646, SE
  • HY-133536
    PA Janelia Fluor® 549, SE
    1 Publications Verification

    PA-JF549-NHS

    		 Fluorescent Dye Others
    PA Janelia Fluor 549, SE (PA-JF549-NHS) is a bright photoactivatable fluorophore of JF549,SE (JF549,NHS). JF549,SE (JF549,NHS) is a fluorescent dye with the absorption maximum (λab (max)) of 549 nm and emission maximum (λem (max)) of 571 nm .
    PA Janelia Fluor® 549, SE
  • HY-140339
    ANB-NOS

    		Biochemical Assay Reagents Others Cancer
    ANB-NOS is a heterobifunctional crosslinker with lipophilic, uncharged properties suitable for intracellular conjugation. ANB-NOS contains an amine-reactive Nhydroxysuccinimide (NHS) ester and a photoactivatable nitrophenyl azide. ANB-NOS can be used for the research of fibrosarcoma and mammary adenocarcinoma .
    ANB-NOS
  • HY-153890
    NVOC cage-TMP-Halo

    		Biochemical Assay Reagents Others
    NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research .
    NVOC cage-TMP-Halo
  • HY-176548
    PY-PAP

    		YAP Annexin A Inflammation/Immunology
    PY-PAP is a photoactivatable affinity probe and a derivative of PY-60 (HY-141644). PY-PAP retains the cellular function of activating YAP transcriptional activity. In 293A cells, PY-PAP can label cathepsin D (CTSD) and annexin A2 (ANXA2) through ultraviolet crosslinking and click reactions. PY-PAP plays a key role in identifying ANXA2 as the specific target of PY-60 .
    PY-PAP
  • HY-131025
    Janelia Fluor® 585, SE

    JF585, SE; JF585, NHS

    		 Fluorescent Dye Others
    Janelia Fluor 585, SE (JF585, SE) is an orange fluorescent dye containing an NHS ester that can be conjugated with primary amine groups. Janelia Fluor 585, SE can be used immediately for structured illumination (SIM) and stimulated emission depletion (STED) imaging and could be converted to photoactivatable derivative for single-molecule localization microscopy (SMLM) experiments . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.
    Janelia Fluor® 585, SE
  • HY-D2923
    PA-JF549-Halo ligand

    		Fluorescent Dye Others
    PA-JF549-Halo ligand is a covalently linked conjugate comprising the photoactivatable fluorescent dye PA-JF549 and a ligand for the HaloTag protein. PA-JF549-Halo ligand exhibts inherent structural properties and predispose it to localize within mitochondria. PA-JF549-Halo ligand combines the exceptional brightness, photostability, and cell permeability of the JF549 dye with photoactivation capabilities and the high specificity characteristic of HaloTag protein labeling technology. PA-JF549-Halo ligand enables high-quality single-molecule imaging and super-resolution imaging of specific proteins within live cells .
    PA-JF549-Halo ligand
  • HY-W895359
    Photoclick myristic acid

    		Biochemical Assay Reagents Others
    Photoclick myristic acid is a derivative of Myristic acid (HY-N2041) with an alkyne group and a photo-activatable diazirine group. Photoclick myristic acid can be used as a probe in protein research .
    Photoclick myristic acid
  • HY-178152
    RuOPt

    		Apoptosis Reactive Oxygen Species (ROS) Photosensitizer Cancer
    RuOPt is a photoactivatable Ru(II)-Pt(IV) complex with reduced dark toxicity. Under irradiation, RuOPt induces apoptosis, generates ROS, and inhibits tumor spheroid growth, demonstrating comparable phototoxicity .
    RuOPt
  • HY-134976
    Azido-FTY720

    		Biochemical Assay Reagents Others
    Azido-FTY720 is a photoactivatable analogue of FTY720. Azido-FTY720 is used for identifying binding sites between FTY720 and its receptors . Azido-FTY720 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-FTY720
  • HY-145323
    Mitochondria-Targeted Photoactivatable Prodrug

    		Biochemical Assay Reagents Cancer
    Mitochondria-Targeted Photoactivatable Proagent accumulates in the mitochondria and shows light-triggered temporally controlled cell death. Mitochondria-Targeted Photoactivatable Proagent can be used in a novel drug delivery platform that provides on-demand, real-time, organelle-specific agent release and monitoring upon photoactivation .
    Mitochondria-Targeted Photoactivatable Prodrug
  • HY-168497
    C-MS023

    		Histone Methyltransferase Cancer
    C-MS023 is a photo-activatable MS023 (HY-19615) prodrug, achieving spatiotemporal inhibition of Histone Arginine Asymmetric Dimethylation. C-MS023 inhibits PRMT6 mediated asymmetric dimethylation of H3 arginine 2 (H3R2me2a), with an estimate IC50 of 0.2224 μM. The photolysis of C-MS023 could be triggered by visible light irradiation at 420 nm, thereby liberating MS023 for effective downregulation of histone arginine asymmetric dimethylation and DNA replication-related transcriptomic activities .
    C-MS023
  • HY-176725
    ZnPcPs

    		Photosensitizer Reactive Oxygen Species (ROS) Cancer
    ZnPcPs is a photosensitizer that generates ROS. ZnPcPs can be used to synthesize the photo-activated BRD4 degrader pZnPc-O3-JQ1 (HY-176724) .
    ZnPcPs
  • HY-133534
    PA-Nic TFA

    		Photosensitizer nAChR Others
    PA-Nic TFA is a photoactivatable nicotine, whcih can be photolyzed with ~405 nm laser flashes to efficiently release nicotine .
    PA-Nic TFA
  • HY-125600
    LY219703

    		Photosensitizer Cancer
    LY219703 is a photoactivatable analogue of the antitumor diarylsulfonylurea sulofenur. LY219703 are distributed mainly in membranes, particularly those of organelles such as mitochondria .
    LY219703
  • HY-170220
    PacFA Ceramide

    		Biochemical Assay Reagents Metabolic Disease
    PacFA Ceramide is a 15-carbon long photoactivatable and clickable fatty acid. PacFA Ceramide can be used for the analysis of protein-lipid interactions in living cells .
    PacFA Ceramide
  • HY-W800683
    4-Azide-TFP-amide-SS-Sulfo-NHS

    		Biochemical Assay Reagents Others
    4-Azide-TFP-Amide-SS-Sulfo-NHS consists of an aryl azide, a cleavable disulfide bond, and an NHS ester. The aryl azide can be photo-activated with UV light (250 to 350 nm) for conjugation with biomolecules. Fluoro helps to stabilize the free radical intermediate. The NHS ester reacts with amines. The disulfide bond can be cleaved by reducing agents.
    4-Azide-TFP-amide-SS-Sulfo-NHS
  • HY-157880
    N3-PC

    Azido-PC

    		 Biochemical Assay Reagents Others
    N3-PC (Azido-PC) is a photoactivatable phosphatidylcholine that can be used in the synthesis of cell membrane structures. N3-PC (Azido-PC) is a click chemistry reagent containing an azide group .
    N3-PC
  • HY-176726
    ZnPc-amide-PEG3-C2-NH2

    		Reactive Oxygen Species (ROS) Cancer
    ZnPc-amide-PEG3-C2-NH2 is a photosensitizer-linker conjugate which consists of ZnPcPs (HY-176725) and a linker (HY-W040165). ZnPc-amide-PEG3-C2-NH2 can be used to synthesize the photo-activated BRD4 degrader pZnPc-O3-JQ1 (HY-176724) .
    ZnPc-amide-PEG3-C2-NH2
  • HY-D3157
    Photoactive esterase probe

    		Fluorescent Dye Others
    Photoactive esterase probe is a photoactivatable fluorescent probe for esterase. Photoactive esterase probe is used for the detection and imaging of esterase activity in living cells .
    Photoactive esterase probe
  • HY-N15960
    Photoclick cholesterol II

    		Biochemical Assay Reagents Others
    Photoclick cholesterol II is a sterol lipid Cholesterol (HY-N0322) analog that contains a clickable terminal alkyne moiety and a photoactivatable diaziridine group.
    Photoclick cholesterol II
  • HY-W190916
    3-((2-(4-Azidobenzamido)ethyl)disulfanyl)propanoic acid

    		Biochemical Assay Reagents Others
    3-[[2-[(4-azidobenzoyl)amino]ethyl]dithio]propanoicacid contains an aryl azide, a cleavable disulfide bond, and a carboxylic acid. The aryl azide can be photo-activated with UV light (250 to 350 nm) for conjugation with biomolecules. The carboxylic acid can be reacted with amines in the presence of an activator to form an amide bond. The disulfide bond can be cleaved via reducing agents.
    3-((2-(4-Azidobenzamido)ethyl)disulfanyl)propanoic acid
  • HY-W800632
    4-Azide-TFP-amide-SS-propionic acid

    		Biochemical Assay Reagents Others
    4-Azide-TFP-Amide-SS-propionic acid contains an aryl azide, a cleavable disulfide bond, and a carboxylic acid. The aryl azide can be photo-activated with UV light (250 to 350 nm) for conjugation with biomolecules. Fluoro helps to stabilize the free radical intermediate. The carboxylic acid can be reacted with amines in the presence of an activator to form an amide bond. The disulfide bond can be cleaved via reducing agents.
    4-Azide-TFP-amide-SS-propionic acid
  • HY-W800635
    4-Azide-TFP-amide-PEG4-acid

    		Biochemical Assay Reagents Others
    4-Azide-TFP-Amide-PEG4-acid contains an aryl azide and a carboxylic acid with a PEG spacer to increase aqueous solubility and decrease steric hinderance during ligation. The aryl azide can be photo-activated with UV light (250 to 350 nm) for conjugation with biomolecules. Fluoro helps to stabilize the free radical intermediate. The carboxylic acid can be reacted with amines in the presence of an activator to form an amide bond.
    4-Azide-TFP-amide-PEG4-acid
  • HY-181072
    POLRMT-IN-4

    		Mitochondrial Metabolism DNA/RNA Synthesis Oxidative Phosphorylation Cancer
    POLRMT-IN-4 is a photoactivated mitochondrial RNA polymerase (POLRMT) inhibitor. POLRMT-IN-4 can be liberated from the photoactivatable prodrug upon irradiation, enables spatiotemporally precise inhibition and localized tissue selectivity. POLRMT-IN-4 disrupts mitochondrial transcription, impairs oxidative phosphorylation, and suppresses cancer cell proliferation. POLRMT-IN-4 can be used in research on various cancers, such as pancreatic cancer .
    POLRMT-IN-4
  • HY-D3446
    PA-SiR-Halo

    		Fluorescent Dye Others
    PA-SiR-Halo is a photoactivatable fluorophore targeting HaloTag. When bound to HaloTag, PA-SiR-Halo stabilizes its fluorescent form under physiological pH. After conjugation and photoactivation, it exhibits enhanced resistance to nucleophiles, and enables live-cell confocal imaging, fixed-cell single-molecule localization microscopy imaging, live-cell single-particle tracking, as well as live-cell single-molecule localization microscopy imaging of dynamic mitochondrial structures without the need for washing .
    PA-SiR-Halo

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