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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
44 Results for "
platelet-activating factor receptor
" in MedChemExpress (MCE) Product Catalog:
Products (44)
44 Results for "platelet-activating factor receptor" in MCE Product Catalog:
43
43 Publications Verification
Synonyms: PAF (C16)
Category:
Human Gut Microbiota Metabolites Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
3
Research Areas:
Apafant (WEB 2086), a chemical probe, is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .
3
Target:
Research Areas:
Rilapladib (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM . Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist .
Research Areas:
C18-PAF, octadecane PAF, is the ligand of platelet-activating factor and PAF G protein-coupled receptor (PAFR). C18-PAF has renovasodilator properties and antihypertensive lipid properties. C18-PAF increases renal blood flow and causes dose-dependent systemic hypotension .
Synonyms: SR27417
Research Areas:
Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [ 3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets .
Research Areas:
MoTP is a specific platelet activating factor receptor antagonist and can induce melanocyte ablation. MoTP can be used for the research of cancer.
Cat. No.: HY-177598
CAS No.: 123852-99-3
Research Areas:
F-0401 is a calcium antagonist with platelet-activating factor receptor (PAFR) antagonistic action. F-0401 can be used for the research of neurological disease, such as stroke .
Cat. No.: HY-W700638A
CAS No.: 76166-55-7
Synonyms: AH 21-132
Research Areas:
Benafentrine maleate is a platelet activating factor receptor (PAFR) antagonist and a PDE 4 inhibitor .
Cat. No.: HY-Y1094
CAS No.: 12092-47-6
Synonyms: Chloro(1,5-cyclooctadiene)rhodium(I) dimer
Target:
Research Areas:
[Rh(cod)Cl]2 (Chloro (1,5-cyclooctadiene) rhodium (I) dimer) is an organometallic rhodium (I) dimer precursor and platelet aggregation inhibitor. [Rh(cod)Cl]2 inhibits PAF-induced aggregation in washed rabbit platelets. [Rh(cod)Cl]2 inhibits aggregation induced by PAF, Thrombin, ADP and Collagen in human platelet-rich plasma. [Rh(cod)Cl]2 acts as a catalyst precursor for the hydrogenation of aromatic hydrocarbons, phenols, olefins and BINOL derivatives. [Rh(cod)Cl]2 is used in the research of cardiovascular diseases such as thromboinflammation-related disorders, tumor metastasis and atherosclerosis .
Cat. No.: HY-106899
CAS No.: 135947-75-0
Research Areas:
MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED50 values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis .
Category:
Cat. No.: HY-19125
CAS No.: 127279-06-5
Research Areas:
BN-50726 is a potent platelet-activating factor (PAF) receptor antagonist. BN-50726 inhibits PAF-induced effects (e.g., [3H]-serotonin release and hypotension) (IC50=5.40 nM). BN-50726 is promising for research of PAF-mediated pathological processes (e.g., inflammation, anaphylaxis, hypotension) .
Cat. No.: HY-U00040
CAS No.: 115621-84-6
Research Areas:
PAF-AN-1 is a platelet activating factor receptor (PAF) antagonist.
Cat. No.: HY-101731
CAS No.: 167011-22-5
Target:
Research Areas:
CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Ki values of 34 nM and 37 nM, respectively .
Cat. No.: HY-10164
CAS No.: 131614-02-3
Research Areas:
E-6123 is a platelet-activating factor (PAF) receptor antagonist.
Cat. No.: HY-122126
CAS No.: 120889-14-7
Research Areas:
BN 52111 is a potent platelet-activating factor (PAF) receptor antagonist .
Cat. No.: HY-19205A
CAS No.: 193739-23-0
Synonyms: LDP-392
Research Areas:
CMI-392 (LDP-392) is an orally active dual 5-lipoxygenase inhibitor and platelet-activating factor receptor (PAFR) antagonist, with an IC50 of 10 nM for human PAF receptor and an IC50 of 100 nM for rat 5-lipoxygenase. CMI-392 blocks PAF receptor binding, inhibits leukotriene synthesis, attenuates PAF-induced hemoconcentration, and suppresses arachidonic acid- and TPA-induced ear swelling in mice. CMI-392 reduces inflammatory cell infiltration, decreases MPO levels, alleviates ocular inflammation, and improves dextran sulfate sodium-induced colitis. CMI-392 can be used in the research of inflammatory and immune-related diseases such as colitis and atopic dermatitis .
Cat. No.: HY-133003
CAS No.: 122328-38-5
Research Areas:
L662,025 is a specific, photolabile and irreversible Platelet-activating factor (PAF-receptor) antagonist, with IC50 values of 5.6 μM (platelet aggregation) and 1 μM (receptor binding), respectively .
Cat. No.: HY-134101
CAS No.: 78858-42-1
Research Areas:
2-O-Ethyl PAF C-16 is a homolog of PAF and a competitive ligand for PAF receptor (Platelet-activating Factor Receptor (PAFR)). 2-O-Ethyl PAF C-16 inhibits the binding of the PAF antagonist WEB 2086 (HY-108634) to the PAF receptor with an IC50 of 21 nM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
