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Art. -Nr.: HY-101731

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CP-96021 hydrochloride

CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with K_i values of 34 nM and 37 nM, respectively.

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CAS. Nr.: 167011-22-5
Formel: C₂₉H₂₂ClFN₄OS
Molecular Weight:529.03

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

CP-96021 hydrochloride Chemical Structure

CAS. Nr.: 167011-22-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

LTC₄

34 nM (Ki)

Platelet activating factor (PAF) receptor

37 nM (Ki)

Alle Leukotriene Receptor Isoform-spezifische Produkte anzeigen :

In Vivo

In vivo, CP-96021 inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED₅₀s of 0.46 and 0.16 mg/kg p.o. respectively. CP-96021 effectively blocks the combined airway obstructive effects of endogenously released PAF and LTD4 stimulated by aerosolized antigen challenge in guinea pigs with an ED₅₀s of 1.8 mg/kg p.o^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 167011-22-5
Molecular Weight 529.03
Formel C₂₉H₂₂ClFN₄OS
SMILES

CC(N1C2=CC=C(OCC3=CC=CC(/C=C/C4=NC5=CC(F)=CC=C5S4)=C3)C=C2)=NC6=C1C=CN=C6.[H]Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. A. Marfat, et al. The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 1995, 5 (13): 1377-1382.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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CP-96021 hydrochloride

Alle Leukotriene Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

CP-96021 hydrochloride Related Classifications

HY-101731 Related Classifications