1. GPCR/G Protein
  2. Leukotriene Receptor
  3. CP-96021 hydrochloride

CP-96021 hydrochloride 

Cat. No.: HY-101731
Handling Instructions

CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Ki values of 34 nM and 37 nM, respectively.

For research use only. We do not sell to patients.

CP-96021 hydrochloride Chemical Structure

CP-96021 hydrochloride Chemical Structure

CAS No. : 167011-22-5

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Description

CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Ki values of 34 nM and 37 nM, respectively[1].

IC50 & Target[1]

LTC4

34 nM (Ki)

Platelet activating factor (PAF) receptor

37 nM (Ki)

In Vivo

In vivo, CP-96021 inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50s of 0.46 and 0.16 mg/kg p.o. respectively. CP-96021 effectively blocks the combined airway obstructive effects of endogenously released PAF and LTD4 stimulated by aerosolized antigen challenge in guinea pigs with an ED50s of 1.8 mg/kg p.o[1].

Molecular Weight

529.03

Formula

C₂₉H₂₂ClFN₄OS

CAS No.

167011-22-5

SMILES

CC(N1C2=CC=C(OCC3=CC=CC(/C=C/C4=NC5=CC(F)=CC=C5S4)=C3)C=C2)=NC6=C1C=CN=C6.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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CP-96021 hydrochloride
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HY-101731
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