1. GPCR/G Protein
  2. Leukotriene Receptor
  3. CP-96021 hydrochloride

CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Ki values of 34 nM and 37 nM, respectively.

For research use only. We do not sell to patients.

CP-96021 hydrochloride Chemical Structure

CP-96021 hydrochloride Chemical Structure

CAS No. : 167011-22-5

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Description

CP-96021 hydrochloride is a balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonist with Ki values of 34 nM and 37 nM, respectively[1].

IC50 & Target[1]

LTC4

34 nM (Ki)

Platelet activating factor (PAF) receptor

37 nM (Ki)

In Vivo

In vivo, CP-96021 inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED50s of 0.46 and 0.16 mg/kg p.o. respectively. CP-96021 effectively blocks the combined airway obstructive effects of endogenously released PAF and LTD4 stimulated by aerosolized antigen challenge in guinea pigs with an ED50s of 1.8 mg/kg p.o[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

529.03

Formula

C29H22ClFN4OS

CAS No.
SMILES

CC(N1C2=CC=C(OCC3=CC=CC(/C=C/C4=NC5=CC(F)=CC=C5S4)=C3)C=C2)=NC6=C1C=CN=C6.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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CP-96021 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CP-96021 hydrochloride
Cat. No.:
HY-101731
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