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Results for "

pterocarpan

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

11

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0616
    Trifolirhizin

    		Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB Infection Metabolic Disease Inflammation/Immunology Cancer
    Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC50 value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders .
    Trifolirhizin
  • HY-N6051
    (-​)​-Maackiain

    		Fungal NOD-like Receptor (NLR) NF-κB Infection Inflammation/Immunology
    (-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .
    (-​)​-Maackiain
  • HY-N3045
    (S,S)-Pisatin

    		Drug Isomer Others
    (S,S)-Pisatin is a dimeric pterocarpan derivative. (S,S)-Pisatin can inhibit plant growth .
    (S,S)-Pisatin
  • HY-N6052
    (+)-Medicarpin

    		Estrogen Receptor/ERR Cancer
    (+)-Medicarpin, a pterocarpan, is a type of isoflavonoid isolated from several medicinal plant species with various biological effects, including Sophora japonica, Zollernia paraensis and Platymiscium yucatamun, Machaerium aristulatum, Platymiscium floribundum, and so on. (+)-Medicarpin potently inhibits osteoclastogenesis and promotes bone healing and increases bone mass by osteoblast differentiation with estrogen receptor (ER) β-mediated osteogenic action .
    (+)-Medicarpin
  • HY-N6051R
    (-)-Maackiain (Standard)

    		Reference Standards Fungal NOD-like Receptor (NLR) NF-κB Infection Inflammation/Immunology
    (-​)​-Maackiain (Standard) is the analytical standard of (-​)​-Maackiain. This product is intended for research and analytical applications. (-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .
    (-)-Maackiain (Standard)
  • HY-N0976
    1,11b-Dihydro-11b-hydroxymedicarpin

    11b-Hydroxy-11b,1-dihydromedicarpin

    		 Interleukin Related Wnt Inflammation/Immunology
    1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative . Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways . Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice .
    1,11b-Dihydro-11b-hydroxymedicarpin
  • HY-N0616R
    Trifolirhizin (Standard)

    		TNF Receptor Reference Standards Tyrosinase Inflammation/Immunology Cancer
    Trifolirhizin (Standard) is the analytical standard of Trifolirhizin. This product is intended for research and analytical applications. Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens. Trifolirhizin possesses potent tyrosinase inhibitory activity with an IC50 of 506 μM . Trifolirhizin exhibits potential anti-inflammatory and anticancer activities .
    Trifolirhizin (Standard)
  • HY-N17980
    (-)-Pterocarpin

    		Drug Derivative Others
    (-)-Pterocarpin is a pterocarpan found in Millettia pulchra .
    (-)-Pterocarpin
  • HY-N7949
    Licoagroside D

    		Others Others
    Licoagroside D is a pterocarpan glycoside found in hairy root cultures of Glycyrrhiza pallidiflora .
    Licoagroside D
  • HY-N17604
    (6aR,11aR)-Edunol

    		Drug Derivative Cancer
    (6aR,11aR)-Edunol (compound 10) is a pterocarpan and antiproliferative agent. (6aR,11aR)-Edunol can be found in the roots of Lonchocarpus bussei and the stem bark of Lonchocarpus eriocalyx. (6aR,11aR)-Edunol exerts antiproliferative effects against drug-sensitive leukemia cells and multidrug-resistant leukemia cells. (6aR,11aR)-Edunol can be used for the research of leukemia .
    (6aR,11aR)-Edunol
  • HY-N9548
    6'-Malonyltrifolirhizin

    Trifolirhizin 6''-O-malonate

    		 Others Others
    6'-Malonyltrifolirhizin (Trifolirhizin 6''-O-malonate) is a malonylated pterocarpan glucoside that can be isolated both from the roots and callus cultures of Sophora flavescens var. angustifolia .
    6'-Malonyltrifolirhizin

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