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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
pyrazole derivative
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "pyrazole derivative" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-19408
CAS No.: 1315323-00-2
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Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca 2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC50 of 0.72 μM (IC50 of 13.08 μM for store operated Ca 2+ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels .
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2 Cited Publications
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CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion .
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1 Cited Publications
Synonyms: Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate
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DMF-DMA (N-Dimethoxymethyl-N,N-dimethylamine) is a reagent with both condensation and alkylation functions. DMF-DMA can undergo condensation reactions with active methylene groups or amino groups to generate enamine and imino derivatives, and can also act as an alkylating agent to methylate nitrogen and oxygen atoms in heterocyclic structures. DMF-DMA is widely used in the synthesis of enaminones and dimethylamino imine intermediates, as well as in the construction of heterocyclic backbones such as pyridine, pyrimidine and pyrazole. DMF-DMA can also serve as a polar aprotic co-solvent; although DMF-DMA cannot dissolve cellulose alone, it can form an efficient cellulose dissolution system with diallylimidazolium methoxyacetate .
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Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities .
Cat. No.: HY-75637
CAS No.: 31230-17-8
Cat. No.: HY-151618
CAS No.: 2750233-50-0
Antitumor agent-79 shows good antiproliferative activities against hepatocellular carcinoma and breast cancer cells with IC50 values of 0.7-7.9 μM. Antitumor agent-79 induces cancer cells apoptosis and shows in vivo antitumor effects. Antitumor agent-79 can be used for the research of cancer .
Synonyms: KVD-824
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Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC50 of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC50>40 μM) .
Cat. No.: HY-W007997
CAS No.: 6994-25-8
Synonyms: 3-Amino-4-ethoxycarbonylpyrazole
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Ethyl 3-amino-1H-pyrazole-4-carboxylate (3-Amino-4-ethoxycarbonylpyrazole) is a diamagnetic pyrazole derivative ligand. Ethyl 3-amino-1H-pyrazole-4-carboxylate can form copper bromide coordination compounds. Ethyl 3-amino-1H-pyrazole-4-carboxylate serves as a ligand for the synthesis of metal coordination compounds .
Cat. No.: HY-W002328
CAS No.: 1621-91-6
Cat. No.: HY-W779244
CAS No.: 51038-79-0
Cat. No.: HY-145568A
CAS No.: 2340299-00-3
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Feniralstat (compound 30) hydrochloride, a pyrazole derivative, is a potent kallikrein inhibitor with an IC50 of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC50>40 μM) .
Cat. No.: HY-W067376
CAS No.: 303180-11-2
Synonyms: pyrazole-3,5-dicarboxylic acid monohydrate
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1H-pyrazole-3,5-dicarboxylic acid hydrate (Pyrazole-3,5-dicarboxylic acid monohydrate) serves as a precursor for the synthesis of 26-membered diazatetraester crown ethers and 39-membered triazahexaester crown ethers containing pyrazole units. 1H-pyrazole-3,5-dicarboxylic acid hydrate acts as a V-type heterocyclic polycarboxylic acid bridging ligand for the construction of Lanthanide III coordination polymers and metal-organic frameworks (MOF) .
Cat. No.: HY-179227
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HDAC6 ligand-7 (Compound 16a) is a positron emission tomography (PET) tracer for the deacetylase 6 (HDAC6) enzyme with a Kd value of 1.66 nM. HDAC6 ligand-7 exhibits excellent HDAC6 inhibitory activity, with IC50 values of 2.7 and 3.7 nM for hHDAC6 and mHDAC6, respectively, and has high selectivity for HDAC1/4/7/8. HDAC6 ligand-7 after being radioactively labeled with fluorine-18, [¹⁸F]HDAC6 ligand-7 shows varying degrees of radioactive uptake in PET, which can reflect the specific binding to HDAC6. HDAC6 ligand-7 can be used for the study of HDAC6 imaging .
Cat. No.: HY-173618
CAS No.: 1431459-41-4
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LQFM020 is an orally active pyrazole derivative. LQFM020 inhibits Ca + and activates K + and NO/cGMP channels to inhibit vasoconstriction. LQFM020 has anti-inflammatory and anti-analgesic activities .
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Cat. No.: HY-128546
CAS No.: 21686-10-2
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Flupranone is a pyrazole derivatives with antiinflammatory and antihypertensive properties .
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Antioxidant agent-11 is a 2-pyrazole-2,3-dihydroquinazolin-4(1H)-one derivative and a weak antioxidant. Antioxidant agent-11 scavenges DPPH free radicals. Antioxidant agent-11 can be used for the research of lung carcinoma .
Cat. No.: HY-B1137S
CAS No.: 1330180-51-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
